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RNA Sequencing and Data Analysis Core

RNA 测序和数据分析核心

基本信息

批准号：
10544816
负责人：
Yu Shyr
金额：
$ 31.29万
依托单位：
VANDERBILT UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-01-22 至 2024-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10544816
关键词：
Academic Medical Centers Address Architecture Area Barrett Esophagus Biogenesis Bioinformatics Biometry Biotechnology ChIP-seq Collaborations Colorectal Cancer Communication DNA sequencing Data Data Analyses Data Set Dedications Ensure Equipment Funding Genes Genomics Goals Grant Human Resources Individual Joints Laboratories Large Intestine Carcinoma Leadership Libraries Link Malignant neoplasm of gastrointestinal tract Messenger RNA Methods MicroRNAs Modification Molecular Multiomic Data National Heart, Lung, and Blood Institute Preparation Principal Investigator Proteins Proteomics Protocols documentation Publications Qi RNA RNA analysis RNA immunoprecipitation sequencing RNA-Binding Proteins Recommendation Recording of previous events Research Design Research Personnel Research Project Grants Resources Ribosomal RNA Services Small RNA System Technology Testing Transfer RNA Translational Research Universities Work analysis pipeline computerized data processing data integration data sharing design experience experimental study extracellular improved laboratory experience lipidomics malignant breast neoplasm member multiple omics novel programs skills tool trafficking transcriptome sequencing transcriptomics

项目摘要

RNA Sequencing and Data Analysis Core Summary: The goal of the RNA Sequencing and Data Analysis Core is to provide a centralized service for RNA sequencing and bioinformatics needs of the program. The benefits of this core include resources and expertise to perform RNA sequencing experiments, access to the most up-to-date equipment, kits and concepts, and cutting edge methods and tools for sequencing and integrative omics analyses. This team is particularly skilled in small RNA and mRNA (long) RNA sequencing and analyses, with emphasis on integration of these data with other -omics datasets. Many of the services provided by the Core have been developed and optimized at Vanderbilt University Medical Center (VUMC) by members of the leadership team, including cutting-edge protocols and analysis pipelines for small RNA sequencing of extracellular RNAs. The Core personnel have complementary expertise in biotechnology, bioinformatics, and biostatistics. The Core will 1) perform high throughput small RNA and total RNA sequencing, as well as other sequencing experiments; 2) provide multi-omics data analysis and interpretation; 3) develop novel integrative methods to discover key regulators in extracellular RNA biogenesis and function in colorectal cancer.

RNA测序和数据分析核心摘要： RNA测序和数据分析核心的目标是为RNA提供集中服务。测序和生物信息学程序的需要。这一核心的好处包括资源和专业知识进行RNA测序实验，获得最先进的设备，试剂盒和概念，用于测序和整合组学分析的尖端方法和工具。该团队特别擅长小RNA和mRNA（长）RNA测序和分析，强调这些数据与其他组学数据集的整合。核心提供的许多服务已经在范德比尔特大学医学中心（VUMC）由领导团队，包括小RNA测序的尖端协议和分析管道，胞外RNA核心人员在生物技术、生物信息学和生物统计学核心将1）进行高通量小RNA和总RNA测序，以及其他测序实验; 2）提供多组学数据分析和解释; 3）开发新的整合发现结直肠癌细胞外RNA生物发生和功能的关键调节因子的方法。