Barrett's Esophagus Translational Research Network Coordinating Center (BETRNetCC)

巴雷特食管转化研究网络协调中心 (BETRNetCC)

• 批准号: 10601202
• 负责人: Yu Shyr
• 金额: $ 14.67万
• 依托单位: VANDERBILT UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-04-08 至 2022-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10601202
• 关键词: Affect; Area; Barrett Esophagus; Biopsy; Clinical; Collaborations; Columnar Epithelium; Communication; Communication Tools; Data; Data Collection; Detection; Development; Disease; Disease Progression; Distal; Endoscopy; Esophageal Adenocarcinoma; Esophagus; Goals; Group Meetings; Health Benefit; Health Care Costs; Incidence; Informed Consent; Intestinal Metaplasia; Investigation; Leadership; Lesion; Logistics; Maintenance; Malignant Neoplasms; Monitor; Morbidity - disease rate; Outcome; Patient-Focused Outcomes; Patients; Periodicity; Persons; Pilot Projects; Play; Preventive measure; Process; Prognosis; Public Health; Reporting; Research; Research Activity; Resources; Risk; Risk Factors; Specimen; Stratified Squamous Epithelium; Time; Translational Research; Vision; biobank; data management; improved; meetings; mortality; patient registry; premalignant; programs; success; symposium; tumor progression; virtual; web portal; working group

PROJECT SUMMARY Although esophageal adenocarcinoma (EAC) is a relatively uncommon cancer, the incidence of this disease has increased rapidly in recent decades; moreover, at the time of detection of EA, most patients have very poor prognosis. The alarming increase in EA over the past several decades, along with the poor prognosis for those affected, demand investigation into the risk factors for this disease, improved management of patients at risk, and development of preventive measures. Advances in these areas will have significant public health benefit in terms of reducing morbidity and mortality for those affected, as well as reducing the public health costs associated with managing EA at advanced stages. To better manage patients at risk for EA will require an improved understanding of the mechanisms of neoplastic progression in the esophagus. Such progression involves the development of Barrett's esophagus, a premalignant lesion in which the normal stratified squamous epithelium of the distal esophagus is replaced by columnar epithelium, visible as an abnormality on endoscopy, and confirmed on biopsy as specialized columnar epithelium with intestinal metaplasia. For these reasons, the NCI has developed the Barrett's Esophagus Translational Research Network (BETRNet), a consortium research initiative with the goal of reducing the incidence, morbidity, and mortality of EAC, through answering key questions related to the progression of this disease, especially in the premalignant stage of BE, the only precursor lesion definitively associated with EA. In this application we describe the accomplishments to date, as well as the vision forward, for the BETRNet Coordinating Center (BETRNet-CC), with the following critical functions: • Administrative and logistical support for the BETRNet program, including efficient communications and coordination of efforts to connect available resources, serve as a data management center, and integrate activities of the research centers; • Coordination of cross-network research through leadership and management of diverse teams, as well as providing logistical and administrative support to the governing body of the BETRNet (the Steering Committee); and • Ongoing development, maintenance, and administration of the BETRNet patient registry with virtual biorepository (BETRNet PR-VB).

项目总结

项目成果

The discovery of novel protein-coding features in mouse genome based on mass spectrometry data.

• DOI: 10.1016/j.ygeno.2011.07.005
• 发表时间: 2011-11
• 期刊: Genomics
• 影响因子: 4.4
• 作者: Xing XB;Li QR;Sun H;Fu X;Zhan F;Huang X;Li J;Chen CL;Shyr Y;Zeng R;Li YX;Xie L
• 通讯作者: Xie L