Barrett's Esophagus Translational Research Network Coordinating Center (BETRNetCC)

巴雷特食管转化研究网络协调中心 (BETRNetCC)

• 批准号: 10601202
• 负责人: Yu Shyr
• 金额: $ 14.67万
• 依托单位: VANDERBILT UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-04-08 至 2022-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10601202
• 关键词: Affect; Area; Barrett Esophagus; Biopsy; Clinical; Collaborations; Columnar Epithelium; Communication; Communication Tools; Data; Data Collection; Detection; Development; Disease; Disease Progression; Distal; Endoscopy; Esophageal Adenocarcinoma; Esophagus; Goals; Group Meetings; Health Benefit; Health Care Costs; Incidence; Informed Consent; Intestinal Metaplasia; Investigation; Leadership; Lesion; Logistics; Maintenance; Malignant Neoplasms; Monitor; Morbidity - disease rate; Outcome; Patient-Focused Outcomes; Patients; Periodicity; Persons; Pilot Projects; Play; Preventive measure; Process; Prognosis; Public Health; Reporting; Research; Research Activity; Resources; Risk; Risk Factors; Specimen; Stratified Squamous Epithelium; Time; Translational Research; Vision; biobank; data management; improved; meetings; mortality; patient registry; premalignant; programs; success; symposium; tumor progression; virtual; web portal; working group

PROJECT SUMMARY Although esophageal adenocarcinoma (EAC) is a relatively uncommon cancer, the incidence of this disease has increased rapidly in recent decades; moreover, at the time of detection of EA, most patients have very poor prognosis. The alarming increase in EA over the past several decades, along with the poor prognosis for those affected, demand investigation into the risk factors for this disease, improved management of patients at risk, and development of preventive measures. Advances in these areas will have significant public health benefit in terms of reducing morbidity and mortality for those affected, as well as reducing the public health costs associated with managing EA at advanced stages. To better manage patients at risk for EA will require an improved understanding of the mechanisms of neoplastic progression in the esophagus. Such progression involves the development of Barrett's esophagus, a premalignant lesion in which the normal stratified squamous epithelium of the distal esophagus is replaced by columnar epithelium, visible as an abnormality on endoscopy, and confirmed on biopsy as specialized columnar epithelium with intestinal metaplasia. For these reasons, the NCI has developed the Barrett's Esophagus Translational Research Network (BETRNet), a consortium research initiative with the goal of reducing the incidence, morbidity, and mortality of EAC, through answering key questions related to the progression of this disease, especially in the premalignant stage of BE, the only precursor lesion definitively associated with EA. In this application we describe the accomplishments to date, as well as the vision forward, for the BETRNet Coordinating Center (BETRNet-CC), with the following critical functions: • Administrative and logistical support for the BETRNet program, including efficient communications and coordination of efforts to connect available resources, serve as a data management center, and integrate activities of the research centers; • Coordination of cross-network research through leadership and management of diverse teams, as well as providing logistical and administrative support to the governing body of the BETRNet (the Steering Committee); and • Ongoing development, maintenance, and administration of the BETRNet patient registry with virtual biorepository (BETRNet PR-VB).

项目概要 虽然食管腺癌（EAC）是一种相对罕见的癌症，但该病的发病率 近几十年来增长迅速；此外，在检测 EA 时，大多数患者已经非常 预后不良。过去几十年来 EA 的增长令人震惊，而且预后不佳 受影响的人要求调查这种疾病的危险因素，改善对患者的管理 风险和预防措施的制定。这些领域的进步将对公共卫生产生重大影响 受益于降低受影响者的发病率和死亡率以及减少公共卫生 与高级阶段管理 EA 相关的成本。 为了更好地管理有 EA 风险的患者，需要更好地了解 EA 的机制 食管肿瘤进展。这种进展涉及巴雷特食管的发育， 远端食管正常复层鳞状上皮被替换的癌前病变 柱状上皮，在内窥镜检查中可见异常，并在活检中证实为特化 柱状上皮伴肠化生。 出于这些原因，NCI 开发了巴雷特食管转化研究网络 (BETRNet)，一项联盟研究计划，旨在降低以下疾病的发生率、发病率和死亡率： EAC，通过回答与该疾病进展相关的关键问题，特别是在 BE 的癌前阶段，唯一与 EA 明确相关的前驱病变。 在此应用程序中，我们描述了 BETRNet 迄今为止所取得的成就以及未来的愿景 协调中心（BETRNet-CC），具有以下关键职能： • 为BETRNet 计划提供行政和后勤支持，包括高效的沟通和 协调工作以连接可用资源，充当数据管理中心并集成 研究中心的活动； • 通过领导和管理不同的团队来协调跨网络研究，以及 为 BETRNet 的管理机构（指导机构）提供后勤和行政支持 委员会）;和 • 通过虚拟技术持续开发、维护和管理 BETRNet 患者登记处 生物样本库（BETRNet PR-VB）。

项目成果

The discovery of novel protein-coding features in mouse genome based on mass spectrometry data.

• DOI: 10.1016/j.ygeno.2011.07.005
• 发表时间: 2011-11
• 期刊: Genomics
• 影响因子: 4.4
• 作者: Xing XB;Li QR;Sun H;Fu X;Zhan F;Huang X;Li J;Chen CL;Shyr Y;Zeng R;Li YX;Xie L
• 通讯作者: Xie L