University of Florida Older Americans Independence Center (OAIC)

佛罗里达大学美国老年人独立中心 (OAIC)

• 批准号: 10291460
• 负责人: Karyn A Esser
• 金额: $ 130万
• 依托单位: UNIVERSITY OF FLORIDA
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-06-01 至 2027-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10291460
• 关键词: Address; Aging; American; Animals; Apoptosis; Area; Artificial Intelligence; Autophagocytosis; Basic Science; Behavior Therapy; Behavioral; Behavioral Sciences; Biological; Biological Markers; Biostatistics Core; Caloric Restriction; Capsicum; Circadian Rhythms; Clinical; Clinical Research; Clinical Trials; Cognitive; Communities; Data Science; Development; Dietary Intervention; Discipline; Elderly; Energy Metabolism; Engineering; Environment; Evidence based practice; Florida; Funding; Future; Geriatrics; Geroscience; Goals; Health; Hospitalization; Human; Impairment; Individual; Inflammation; Intermittent fasting; Intervention; Investigation; Knowledge; Leadership; Locomotion; Metabolism; Mission; Mitochondria; Molecular Biology; Morbidity - disease rate; Multicenter Trials; Nutraceutical; Obesity; Oxidative Stress; Pharmacology; Phase; Physical Exercise; Physical Function; Physical Performance; Prevention; Program Development; Public Health; Quality of life; Research; Research Personnel; Research Support; Research Training; Resources; Risk Factors; Role; Science; Services; Skeletal Muscle; Technology; Testing; Training; Translating; Translational Research; Translations; Universities; age related; behavioral pharmacology; career development; cognitive function; cohesion; comorbidity; disability; education research; effective intervention; efficacious intervention; epidemiologic data; exercise intervention; experience; handheld mobile device; improved mobility; interdisciplinary approach; invention; minority health disparity; mortality; multidisciplinary; novel strategies; physical model; physically handicapped; preclinical study; prevent; programs; psychosocial; public health relevance; racial and ethnic; research and development; sarcopenia; skills; success; virtual

Project Summary The mission of the University of Florida Older Americans Independence Center (OAIC) is twofold: 1) to optimize older persons’ physical performance and mobility through interdisciplinary approaches to promote independence; and 2) to train early stage investigators in aging and disability research while developing their leadership qualities. Our goal is to enhance late-life health and independence, with a special focus on mobility. To accomplish our mission, our strategy is to attract studies and inventive investigators from diverse behavioral, clinical, basic, and technological science disciplines with a common research focus on “promotion of mobility and independence.” Traversing the entire spectrum of biomedical investigation, including molecular biology, animal studies, clinical research, behavioral sciences, epidemiology, data science, artificial intelligence, and engineering, our research effort addresses the OAIC’s general goal: to increase scientific knowledge that leads to better ways to maintain or restore independence of older people. Our research objectives are to: 1) assess, using geroscience and translational research, the biological, co-morbid, psychosocial, environmental, behavioral, cognitive, and other factors that contribute to cognitive and physical function decline, loss of mobility, and loss of independence; and 2) develop and reliably test, in clinical and preclinical studies, interventions that target mobility to prevent, delay, or recover the age-related declines in physical and cognitive function. Our educational objective is to train future leaders in clinical translational research on aging. To meet these objectives the proposed OAIC trains Research Education Core (REC) Scholars and supports investigators, resources, services, external studies, development projects, and pilot/exploratory studies through seven integrated cores: • Leadership and Administrative Core (LAC); • Research Education Core (REC); • Pilot/Exploratory Studies Core (PESC); • Clinical Research Core (RC1); • Metabolism and Translational Science Core (RC2); • Biostatistics Core (RC3); and • Data Science and Applied Technology Core (RC4). In this renewal OAIC application we will augment the wealth of expertise and remarkable track record of success of the current funding cycle. A relevant strength of our OAIC is the concerted action of the interdisciplinary cores, projects, and investigators who address one common research focus spanning the entire spectrum of biomedical investigation.

项目概要 佛罗里达大学美国老年人独立中心 (OAIC) 的使命有两个：1) 优化 通过跨学科方法促进老年人的身体机能和活动能力 独立; 2）培训老龄化和残疾研究的早期研究人员，同时发展他们的能力 领导素质。我们的目标是增强晚年健康和独立性，特别关注行动能力。 为了完成我们的使命，我们的策略是吸引来自不同行为、 临床、基础和技术科学学科，共同研究重点是“促进流动性” 和独立。”穿越整个生物医学研究领域，包括分子生物学， 动物研究、临床研究、行为科学、流行病学、数据科学、人工智能和 工程方面，我们的研究工作致力于实现 OAIC 的总体目标：增加科学知识，从而引领 更好地保持或恢复老年人的独立性。我们的研究目标是：1）评估， 利用老年科学和转化研究，生物学、共病、心理、环境、 导致认知和身体功能下降、行动能力丧失的行为、认知和其他因素， 以及失去独立性； 2) 在临床和临床前研究中开发并可靠地测试干预措施 以活动能力为目标，以预防、延缓或恢复与年龄相关的身体和认知功能下降。我们的 教育目标是培养衰老临床转化研究的未来领导者。为了满足这些 拟议的 OAIC 培训研究教育核心 (REC) 学者并支持研究人员的目标， 资源、服务、外部研究、开发项目和试点/探索性研究通过七个 集成核心： • 领导和行政核心（LAC）； • 研究教育核心（REC）； • 试点/探索性研究核心（PESC）； • 临床研究核心（RC1）； • 代谢和转化科学核心（RC2）； • 生物统计学核心（RC3）；和 • 数据科学和应用技术核心(RC4)。 在这个更新的 OAIC 申请中，我们将增加丰富的专业知识和卓越的业绩记录 当前融资周期的成功。我们 OAIC 的一个相关优势是各方的一致行动 跨学科核心、项目和研究人员，他们致力于跨越整个领域的一个共同研究焦点 生物医学研究的范围。