Chromosome Metabolism and Cancer Training Grant

染色体代谢和癌症培训补助金

• 批准号: 10604542
• 负责人: Robert Neil Eisenman
• 金额: $ 11.91万
• 依托单位: FRED HUTCHINSON CANCER CENTER
• 依托单位国家: 美国
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-04-01 至 2022-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10604542
• 关键词: Chromosome; Metabolism; Cancer; Training; Grant

Project Summary/Abstract This revised application seeks renewal of the Chromosome Metabolism and Cancer Training Grant (CMCTG) at the Fred Hutchinson Cancer Research Center (Fred Hutch), an NCI-designated Comprehensive Cancer Center. The training program bridges the gap between basic and translational cancer research by bringing together young translational and basic scientists in one of the nation’s premier cancer research institutions, the Fred Hutchinson Cancer Research Center (Fred Hutch), and leverages the synergies emerging from an extraordinarily wide range of ongoing research. The CMCTG is the only Fred Hutch institutional training grant (T32) that is focused on molecular mechanisms of cancer. The 26 training faculty members include four junior faculty members who are being developed as the next generation of research mentors. Of the 22 senior trainers, four are members of the National Academy of Sciences and three are Howard Hughes Medical Institute Investigators. All of the training faculty have vigorous research programs and external funding, and most have support from the NCI, ACS, DoD or cancer foundations. The program is administered by the PI and Assistant PI and a Steering Committee comprising four of the training faculty plus the head of the Office of Scientific Career Development and an External Advisor. The goal of the program is to train young scientists toward a career in cancer research with special emphasis on investigating fundamental molecular and cell biology of normal and cancer cells. Our training program is based on the concept that the prevention, diagnosis, and treatment of cancer will require a profound understanding of the molecular mechanisms that underlie the behavior of normal cells and drive the initiation, progression, and maintenance of tumors and their environment. Training occurs in small, dedicated research labs on an integrated campus, allowing close monitoring of trainee progress, effective mentoring of junior members of the Training Faculty, and frequent exchange of ideas between trainees and mentors. Extensive core facilities support cutting-edge research. Over the past 10 years, the CMCTG has impacted the careers of 11 pre-doctoral and 35 postdoctoral trainees, of whom 2 predocs and 6 postdocs are still supported. 9 trainees are/were from under-represented minority groups. Of the 38 past trainees, 8 are junior faculty in research or teaching at universities, 8 are staff scientists or in science administration in academic settings, 5 have research positions in biotech, 14 remain in training at Fred Hutch or other institutions, 1 is deceased, 1 is on medical leave, and 1 is a homemaker. Seven postdoctoral trainees obtained independent research fellowships from the American Cancer Society, and four predoctoral trainees won prestigious NSF predoctoral fellowships. We plan to continue this record of success into the future.

项目摘要/摘要 这项修订申请寻求续期染色体代谢和癌症培训补助金(CMCTG) 在弗雷德·哈钦森癌症研究中心(弗雷德·哈奇)，NCI指定的综合癌症 中心。该培训计划通过将基础癌症研究和转化性癌症研究 在美国一流的癌症研究机构中，年轻的转化型和基础科学家汇聚一堂 弗雷德·哈钦森癌症研究中心(弗雷德·哈奇)，并利用 非常广泛的正在进行的研究。CMCTG是弗雷德·哈奇唯一的机构培训赠款 (T32)，重点是癌症的分子机制。26名培训教员包括4名初级教职员工 正在被培养成下一代研究导师的教职员工。在22名高年级学生中 培训师，四名是国家科学院成员，三名是霍华德·休斯医学院成员 研究所的调查人员。所有的培训教师都有强有力的研究计划和外部资金，以及 大多数人都得到了NCI、ACS、国防部或癌症基金会的支持。该计划由PI管理，并且 助理PI和一个指导委员会，该委员会由四名培训教员和#年办公室主任组成 科学的职业发展和外部顾问。该计划的目标是培养年轻的科学家 走向癌症研究的职业生涯，特别强调研究基础分子和细胞 正常细胞和癌细胞的生物学。我们的培训计划是基于这样一个概念，即预防， 癌症的诊断和治疗将需要对分子机制的深刻理解 是正常细胞行为的基础，并推动肿瘤和它们的发生、发展和维持 环境。培训在一个综合园区的小型专用研究实验室进行，允许近距离 监测实习生的进展，有效指导培训学院的初级成员，并经常 学员和导师之间的思想交流。广泛的核心设施支持尖端研究。完毕 在过去的10年里，CMCTG影响了11名博士后和35名博士后实习生的职业生涯， 其中仍支持2名博士后和6名博士后。9名受训人员来自代表性不足的少数族裔 组。在过去的38名学员中，8人是大学研究或教学的初级教员，8人是教职员工。 或学术环境中的科学管理，5人拥有生物技术研究职位，14人仍在接受培训 弗雷德·哈奇或其他机构，1人死亡，1人病假，1人是家庭主妇。七 博士后实习生获得了美国癌症协会的独立研究奖学金，并有四名 博士前实习生获得了享有盛名的NSF博士前奖学金。我们计划继续保持这一成功纪录。 通向未来。

项目成果

Local chromatin fiber folding represses transcription and loop extrusion in quiescent cells.

• DOI: 10.7554/elife.72062
• 发表时间: 2021-11-04
• 期刊: eLife
• 影响因子: 7.7
• 作者: Swygert SG;Lin D;Portillo-Ledesma S;Lin PY;Hunt DR;Kao CF;Schlick T;Noble WS;Tsukiyama T
• 通讯作者: Tsukiyama T

RSC primes the quiescent genome for hypertranscription upon cell-cycle re-entry.

• DOI: 10.7554/elife.67033
• 发表时间: 2021-05-27
• 期刊: eLife
• 影响因子: 7.7
• 作者: Cucinotta CE;Dell RH;Braceros KC;Tsukiyama T
• 通讯作者: Tsukiyama T

Restriction of Src activity by Cullin-5.

• DOI: 10.1016/j.cub.2008.12.007
• 发表时间: 2009-01-27
• 期刊: Current biology : CB
• 作者: Laszlo GS;Cooper JA
• 通讯作者: Cooper JA

Putting Glioblastoma in Its Place: IRF3 Inhibits Invasion.

• DOI: 10.1016/j.molmed.2017.07.008
• 发表时间: 2017-09
• 期刊: Trends in molecular medicine
• 影响因子: 13.6
• 作者: Pattwell SS;Holland EC
• 通讯作者: Holland EC

Mapping regulatory factors by immunoprecipitation from native chromatin.

通过天然染色质的免疫沉淀来绘制调节因子。

• DOI: 10.1002/0471142727.mb2131s110
• 发表时间: 2015
• 期刊: Current protocols in molecular biology
• 作者: Orsi,GuillermoA;Kasinathan,Sivakanthan;Zentner,GabrielE;Henikoff,Steven;Ahmad,Kami
• 通讯作者: Ahmad,Kami