CHROMOSOME METABOLISM AND CANCER

染色体代谢与癌症

• 批准号: 6751505
• 负责人: Jonathan A Cooper
• 金额: $ 33.08万
• 依托单位: FRED HUTCHINSON CANCER RESEARCH CENTER
• 依托单位国家: 美国
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-04-01 至 2006-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6751505
• 关键词: CHROMOSOME; METABOLISM; CANCER

DESCRIPTION: (provided by Applicant) This renewal application is seeking support for a program that trains researchers to understand the links between chromosome metabolism and cancer. Recent advances in the studies of genes and genomes have greatly facilitated the understanding of chromosome metabolism and illustrated its importance in cancer cell formation and progression. The 27 training faculty are experts in this area from the Basic Sciences Division and the Human Biology Division of Fred Hutchinson Cancer Research Center. Many are leading scientists in their own fields, and together they form a cohesive group that approaches the issue from different but complementing angles. They include structural biologists in addition to molecular and cellular biologists, and utilize various model organisms such as nematode, fly, yeast in addition to vertebrates and cultured cells in their studies. The breadth and depth of this program should help generate excellent young scientists ready to deal with this complex problem. The program will continue to train at the predoctoral and postdoctoral levels. Three predoctoral positions are requested to maintain the current level of support of this successful program that was initiated five years ago following the formation of the Molecular and Cell Biology (MCB) Graduate Program. The postdoctoral positions will be expanded to six (from the current four positions) due to increased interests in this area and the expanded training faculty of the program (from 14 to 27). Predoctoral trainees will be recruited among the MCB students, who enter the joint program with the University of Washington, through vigorous competition and are among the best in the nation. Postdoctoral trainees will be recruited nationally. Training of predoctoral students includes course work, laboratory rotations and thesis research. Postdoctoral training will focus on independent research. All t r ainees will benefit from the rich activities available for cancer researchers at this Center. They will participate in weekly research group meetings, joint group meetings and Division meetings to report research findings to and exchange ideas with scientists within the lab, labs with similar interests, or the entire Divisions. They will also benefit from the strong interdisciplinary programs in the Center that expose basic scientists to clinical and public health aspects of cancer. In addition, they will have ready access to the newly formed patient care unit on campus. It is hoped that this program will train young scientists with in-depth understanding of chromosome metabolism and able to explore its various links to cancer cause, care and prevention.

产品说明： （由申请人提供）本续期申请寻求 支持一项培训研究人员了解 染色体代谢和癌症 基因和蛋白质组学研究的新进展 基因组极大地促进了对染色体代谢的理解 并阐明了其在癌细胞形成和发展中的重要性。 的 27名培训教师是基础科学部在这一领域的专家 和弗雷德哈钦森癌症研究中心人类生物学部门。 许多人都是各自领域的顶尖科学家，他们共同组成了一个 从不同但互补的角度处理问题的有凝聚力的小组 的角度 他们包括结构生物学家除了分子和 细胞生物学家，并利用各种模式生物，如线虫， 苍蝇、酵母以及脊椎动物和培养细胞。 该计划的广度和深度应有助于培养优秀的年轻人， 科学家们已经准备好解决这个复杂的问题。 该计划将继续在博士前和博士后水平的培训。 三个博士前职位被要求保持目前的水平， 支持这个成功的计划，是在五年前启动后， 分子和细胞生物学（MCB）研究生课程的形成。 的 博士后岗位将从目前的4个增加到6个 由于对这一领域的兴趣增加和培训范围扩大， 该计划的教师（从14至27）。 实习生将在 从MCB学生中招募，他们与 华盛顿大学通过激烈的竞争而名列前茅 在全国范围内。 博士后研究生将在全国范围内招募。 培训 包括课程工作，实验室轮换和论文 research. 博士后培训将侧重于独立研究。 所有 t rainees将受益于丰富的活动可用于癌症 该中心的研究人员。 他们将参加每周的研究小组 会议、联合小组会议和分部会议，以报告研究情况 研究结果，并与实验室内的科学家交换意见， 类似的利益，或整个部门。 他们还将受益于 该中心强大的跨学科项目，使基础科学家 癌症的临床和公共卫生方面。 此外，他们还将拥有 随时可以进入校园内新成立的病人护理单位。 希望 该项目将培养年轻科学家， 染色体代谢，并能够探索其与癌症原因的各种联系， 护理和预防。