CHROMOSOME METABOLISM AND CANCER

染色体代谢与癌症

• 批准号: 6632845
• 负责人: MENG-CHAO H YAO
• 金额: $ 25.82万
• 依托单位: FRED HUTCHINSON CANCER RESEARCH CENTER
• 依托单位国家: 美国
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-04-01 至 2006-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6632845
• 关键词: CHROMOSOME; METABOLISM; CANCER

DESCRIPTION: (provided by Applicant) This renewal application is seeking support for a program that trains researchers to understand the links between chromosome metabolism and cancer. Recent advances in the studies of genes and genomes have greatly facilitated the understanding of chromosome metabolism and illustrated its importance in cancer cell formation and progression. The 27 training faculty are experts in this area from the Basic Sciences Division and the Human Biology Division of Fred Hutchinson Cancer Research Center. Many are leading scientists in their own fields, and together they form a cohesive group that approaches the issue from different but complementing angles. They include structural biologists in addition to molecular and cellular biologists, and utilize various model organisms such as nematode, fly, yeast in addition to vertebrates and cultured cells in their studies. The breadth and depth of this program should help generate excellent young scientists ready to deal with this complex problem. The program will continue to train at the predoctoral and postdoctoral levels. Three predoctoral positions are requested to maintain the current level of support of this successful program that was initiated five years ago following the formation of the Molecular and Cell Biology (MCB) Graduate Program. The postdoctoral positions will be expanded to six (from the current four positions) due to increased interests in this area and the expanded training faculty of the program (from 14 to 27). Predoctoral trainees will be recruited among the MCB students, who enter the joint program with the University of Washington, through vigorous competition and are among the best in the nation. Postdoctoral trainees will be recruited nationally. Training of predoctoral students includes course work, laboratory rotations and thesis research. Postdoctoral training will focus on independent research. All t r ainees will benefit from the rich activities available for cancer researchers at this Center. They will participate in weekly research group meetings, joint group meetings and Division meetings to report research findings to and exchange ideas with scientists within the lab, labs with similar interests, or the entire Divisions. They will also benefit from the strong interdisciplinary programs in the Center that expose basic scientists to clinical and public health aspects of cancer. In addition, they will have ready access to the newly formed patient care unit on campus. It is hoped that this program will train young scientists with in-depth understanding of chromosome metabolism and able to explore its various links to cancer cause, care and prevention.

描述：（由申请人提供）此续签申请正在寻求 支持一项培训研究人员了解之间联系的计划 染色体代谢与癌症。 基因和基因研究的最新进展 基因组极大地促进了对染色体代谢的理解 并说明了其在癌细胞形成和进展中的重要性。 这 27名培训教师是基础科学部该领域的专家 以及弗雷德·哈钦森癌症研究中心的人类生物学部。 许多人都是各自领域的顶尖科学家，他们共同组成了一个 一个有凝聚力的团队，从不同但互补的角度处理问题 角度。 除了分子和生物学家之外，他们还包括结构生物学家 细胞生物学家，并利用各种模型生物，例如线虫， 他们的研究中包括苍蝇、酵母以及脊椎动物和培养细胞。 该计划的广度和深度应该有助于培养优秀的年轻人 科学家们准备好解决这个复杂的问题。 该计划将继续在博士前和博士后层面进行培训。 需要三个博士前职位来维持目前的水平 对五年前发起的这一成功计划的支持 分子和细胞生物学（MCB）研究生项目的形成。 这 博士后职位将扩大到6个（目前为4个） 职位）由于对该领域的兴趣增加和培训范围扩大 该项目的教员（从 14 名增至 27 名）。 博士前培训生将 在 MCB 学生中招募，他们进入与 华盛顿大学通过激烈的竞争而名列前茅 在全国。 面向全国招聘博士后。 训练 博士前学生包括课程作业、实验室轮转和论文 研究。 博士后培养将侧重于独立研究。 全部 学员将受益于丰富的癌症活动 该中心的研究人员。 他们将参加每周的研究小组 会议、联席会议和部门会议报告研究 向实验室内的科学家提供发现并与他们交换想法 相似的利益，或整个部门。 他们也将受益于 该中心有强大的跨学科项目，可以接触基础科学家 癌症的临床和公共卫生方面。 此外，他们还将拥有 随时可以使用校园内新成立的病人护理部门。 希望 该项目将培养对以下领域有深入了解的年轻科学家 染色体代谢并能够探索其与癌症病因的各种联系， 护理和预防。