CHROMOSOME METABOLISM AND CANCER

染色体代谢与癌症

• 批准号: 2683390
• 负责人: RONALD H REEDER
• 金额: $ 16.03万
• 依托单位: FRED HUTCHINSON CANCER RESEARCH CENTER
• 依托单位国家: 美国
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-04-01 至 2001-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2683390
• 关键词: CHROMOSOME; METABOLISM; CANCER

This is a competitive renewal application for a program to train students to do basic research in the association between chromosome structure and cancer. In continuation of our past program, we are requesting stipends for four trainees at the postdoctoral level. In addition, we are requesting three stipends for training at the predoctoral level. The predoctoral stipend request is appropriate due to the Hutchinson Center's recent authorization to grant the Ph.D. degree in Molecular and Cellular Biology by the State of Washington Higher Education Coordinating Board (granted September 1, 1993). The Center also recently entered an affiliation agreement with the University of Washington (July 1, 1994) and began the first year of the joint Molecular and Cellular Biology Graduate Program with the entering class of September 1994. Training will be performed by a faculty of fourteen investigators, all of whom are members of the Basic Sciences Division of the Fred Hutchinson Cancer Research Center. Each faculty member is a recognized expert in his or her own field and has an extensive record of successful training at both the graduate and postgraduate levels. A strength of the program is the diversity of cancer-related model systems under study by the faculty, ranging from genetics of the cell cycle to the enzymology of transcript ion initiation and termination. Predoctoral trainees will be selected from the pool of high quality students admitted yearly to the graduate program. First year students initially rotate through three different laboratories at both the Hutchinson Center and the University before choosing a mentor with whom to do thesis research. Students whose interests are related to cancer will be given priority to be supported by the proposed program. Postdoctoral trainee are selected from a national pool of applicants. In addition to becoming immersed in their chosen research topic, both groups of trainees are encouraged to participate in the intellectual life of the Basic Sciences Division. This includes specialty journal clubs, joint laboratory meetings, and a regular series of seminars by outside speakers. In addition, trainees are expected to present their own findings at regular intervals, both in small group meetings as well as in a more formal weekly research seminar that is attended by the entire Division. This type of training has been shown to be effective in producing young investigators who are capable of independent, creative scientific research in the molecular basis of cancer.

这是针对培训学生的计划的竞争性更新申请 在染色体结构与 癌症。 在继续我们的过去计划时，我们要求津贴 在博士后一级的四名学员。 此外，我们是 请求三个津贴进行培训。 这 由于哈钦森中心的 授予博士学位的最新授权分子和细胞的程度 华盛顿州高等教育协调委员会的生物学 （授予1993年9月1日）。 该中心最近也进入了 华盛顿大学的隶属协议（1994年7月1日） 并开始了联合分子和细胞生物学的第一年 1994年9月的进入课程的研究生课程。 培训将由14名调查员的教职员工进行 他们是弗雷德·哈钦森（Fred Hutchinson）基本科学系的成员 癌症研究中心。每个教职员工都是公认的专家 或她自己的领域，并在成功的培训中有广泛的记录 研究生和研究生水平。该程序的优势是 教师正在研究的癌症相关模型系统的多样性， 从细胞周期的遗传学到转录的酶学 离子的启动和终止。 将从高质量的库中选出托管前学员 学生每年录入研究生课程。第一年的学生 最初在两个不同的实验室旋转 哈钦森中心和大学，然后选择一位导师 进行论文研究。 与癌症有关的兴趣的学生 将优先考虑拟议计划的优先级。 博士后学员是从国家申请人池中选出的。在 除了沉浸在他们选择的研究主题中，这两个小组 鼓励学员参加 基本科学部。这包括专业期刊俱乐部，联合 实验室会议和外部定期研讨会 演讲者。此外，学员有望展示自己的 在小组会议和 在更正式的每周研究研讨会中 分配。这种类型的培训已被证明是有效的 生产能够独立，创意的年轻调查员 科学研究在癌症的分子基础上。