Brain Organization and Network Connectivity in Persistent Reading Difficulties: A Multimodal Neuroimaging Study

持续性阅读困难中的大脑组织和网络连接：多模式神经影像研究

• 批准号: 10360556
• 负责人: Arturo E Hernandez
• 金额: $ 27.9万
• 依托单位: UNIVERSITY OF HOUSTON
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-06-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10360556
• 关键词: Academic achievement; Academic skills; Address; Adolescence; Adopted; Age; Attention; Attention deficit hyperactivity disorder; Behavior; Behavior Therapy; Brain; Brain imaging; Brain region; Categories; Child; Cognitive; Community Networks; Comprehension; Corpus striatum structure; Data; Data Set; Development; Diffusion Magnetic Resonance Imaging; Digit structure; Dimensions; Dorsal; Educational Intervention; English Learner; Functional Magnetic Resonance Imaging; Future; Goals; Image; Individual; Individual Differences; Inferior; Instruction; Intervention; Intervention Studies; Judgment; Language; Learning Disabilities; Linear Models; Magnetic Resonance Imaging; Mathematics; Measures; Mediating; Modeling; Multimodal Imaging; Multivariate Analysis; Neurobiology; Neurosciences Research; Outcome; Parietal; Pathway Analysis; Pathway interactions; Pattern; Performance; Predictive Value of Tests; Process; Property; Psychometrics; Reader; Reading; Reading Disabilities; Research Design; Rest; Scanning; School-Age Population; Signal Transduction; Specificity; Students; Testing; Texas; Text; Thick; Time; Training; base; bilingualism; cognitive neuroscience; cohort; comorbidity; design; eighth grade; graph theory; imaging approach; imaging study; improved; indexing; individual response; individual variation; junior high school; mathematical difficulties; member; multi-component intervention; multimodal neuroimaging; multimodality; myelination; neural correlate; neural network; neuroimaging; novel; peer; predicting response; prognostic value; reading difficulties; relating to nervous system; response; segregation; seventh grade; sex; standardize measure; successful intervention; tool; white matter

Growing evidence from multimodal brain imaging studies highlights the importance of a synergistic approach towards characterizing the neurobiological substrate of reading disability (RD). The overall goal of Project 4 (Imaging) is to develop a comprehensive model of brain network connectivity changes that relate to changes in academic skills. Academic skills interface with task control and attention brain networks in important but poorly understood ways. Project 4 will supplement the cognitive framework developed within Project 2 (Attention). In addition, we propose to evaluate features of brain organization associated with developmental outcomes of the educational interventions addressed in Project 3 (Intervention). Project 4 (Neuroimaging) will address three aims. The first aim is to characterize structural and functional brain connectivity related to change in academic skills and attention abilities, using a dimensional and multimodal imaging approach (Resting-state fMRI, quantitative structural MRI, and DTI). We will use multiple task localizers to generate regions to serve as nodes for network analyses at the individual and group levels and analyze network changes over 3 scans spanning the two years of middle school (beginning of 7th grade, end of 7th, end of 8th grade). The second aim is to test for brain network relationships that are impacted by bilingual language proficiency, and comorbid conditions (e.g. ADHD) within a group of English language learners who have persistent reading difficulties. This aim models individual response to educational interventions (Project 3) as a function of aberrant features of brain organization and connectivity, and uses a rich contextual dataset (Project 2) to test for the impact of important interacting factors. The third aim tests the predictive value of pre-intervention brain data for subsequent response to intervention. Addressing this aim entails training a multivariate pattern analysis model with cohort 1 data (years 1-3), and evaluating the results of that model with independent data from cohort 2 (years 3-5). We will test which type of brain data (e.g. DTI, cortical thickness, resting-state) best predicts future group membership (improver vs. non-improver). We predict that future academic gains will be stronger for those with stronger structural connectivity and tighter within-network correlations (better brain tuning). By successfully addressing these aims, Project 4 will promote novel directions in cognitive neuroscience research featuring longitudinal, multimodal imaging analysis of academic change, identifying features of brain organization that are crucial for typical development of academic skills and predicting successful intervention outcomes.

多模式脑成像研究中越来越多的证据凸显了协同方法的重要性 旨在描述阅读障碍（RD）的神经生物学基础。项目4总体目标 （成像）是开发一个与大脑网络连接变化相关的综合模型 学术技能。学术技能与任务控制和注意力脑网络的接口很重要但很差 了解方法。项目 4 将补充项目 2（注意力）中开发的认知框架。在 此外，我们建议评估与发育结果相关的大脑组织特征 项目 3（干预）中涉及的教育干预措施。项目 4（神经影像）将解决三个问题 目标。第一个目标是表征与学术变化相关的结构和功能性大脑连接。 技能和注意力能力，使用维度和多模态成像方法（静息态功能磁共振成像， 定量结构 MRI 和 DTI）。我们将使用多个任务定位器来生成区域作为节点 用于个人和团体级别的网络分析，并分析 3 次扫描的网络变化 中学两年（七年级开始、七年级结束、八年级结束）。第二个目的是测试 对于受双语能力和共病影响的大脑网络关系 （例如 ADHD）存在于一群持续存在阅读困难的英语学习者中。这个目标 将个人对教育干预的反应（项目 3）建模为大脑异常特征的函数 组织和连​​接性，并使用丰富的上下文数据集（项目 2）来测试重要的影响 相互作用的因素。第三个目标测试干预前大脑数据对后续干预的预测价值 对干预的反应。实现这一目标需要通过队列训练多变量模式分析模型 1 数据（第 1-3 年），并使用来自队列 2（第 3-5 年）的独立数据评估该模型的结果。 我们将测试哪种类型的大脑数据（例如 DTI、皮质厚度、静息状态）最能预测未来群体 成员资格（改进者与非改进者）。我们预测，对于那些具有以下特征的人来说，未来的学术成就将会更大 更强的结构连接性和更紧密的网络内相关性（更好的大脑调整）。 通过成功实现这些目标，项目 4 将推动认知神经科学的新方向 研究以学术变化的纵向、多模态成像分析为特色，识别大脑特征 对于学术技能的典型发展和预测成功干预至关重要的组织 结果。