Biological predictors of brain aging trajectories

大脑衰老轨迹的生物学预测因子

• 批准号: 10052959
• 负责人: JOEL H KRAMER
• 金额: $ 512.71万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-06-15 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10052959
• 关键词: Affect; Age; Aging; Alzheimer' s Disease; American; Amyloid; Amyloid beta-Protein; Anisotropy; Award; Awareness; Behavioral; Biological; Biological Markers; Biometry; Blood Vessels; Brain; Brain Pathology; CCL2 gene; Clinical; Cognition; Cognitive; Complex; Diet; Disease; Elderly; Endothelium; Episodic memory; Exercise; Exhibits; Genomics; Goals; Gold; Health Benefit; Healthcare Systems; Impaired cognition; Individual; Inflammation; Inflammatory; Injury; Interleukin-6; Intervention; Life Style; Light; Liquid substance; Literature; Magnetic Resonance Imaging; Maps; Measurable; Measures; Medial; Memory; Modeling; Nerve Degeneration; Outcome; Pathology; Pathway interactions; Patient Self-Report; Pattern; Persons; Phenotype; Physical activity; Plasma; Positron-Emission Tomography; Predictive Value; Prevention; Process; Proteins; Proxy; Public Health; REM Sleep; Risk; Role; Sampling; Scientific Advances and Accomplishments; Sleep; Stage II Sleep; Stress; Structure; Subgroup; Symptoms; TNF gene; Techniques; Temporal Lobe; Testing; Time; White Matter Hyperintensity; age related; aging brain; apolipoprotein E-4; base; cerebrovascular; cognitive ability; cohort; executive function; gray matter; individual variation; inflammatory marker; innovation; minimally invasive; multimodality; neurofilament; neuroimaging; novel; predictive modeling; predictive test; prevent; processing speed; protein aggregation; protein biomarkers; regression trees; tau Proteins; tau-1; white matter; β-amyloid burden

PROJECT SUMMARY /ABSTRACT There is considerable individual variability in how much and how quickly cognitive abilities change with age. The better we understand the biological mechanisms that influences if and how aging affects brain structure and function, the more able we will be to intervene effectively in a person-specific manner. The overarching goal of this renewal application is to better understand the inflammatory, vascular, neurodegenerative, and lifestyle/behavioral contributions to this clinically important diversity in brain aging trajectories. We propose to continue following our deeply phenotyped cohort of 250 functionally intact older normals with our detailed cognitive, neuroimaging, and biometric characterizing over two additional time points. Our first aim is to define the separate and interactive pathways by which biologic and lifestyle variables influence age-related decline in brain structure and function Our second aim will determine of predictive value of innovative plasma markers of proteins associated with Alzheimer’s and neurodegeneration. Our third aim will incorporate innovative, objective, real-time measures of sleep and physical activity. Accomplishing these aims will have a highly significant impact on the field. Validating plasma biomarkers of pathology and clarifying the complex interplay of factors that influence brain aging trajectories will lead to better prediction and prevention of adverse brain aging and inform person-specific interventions.

项目总结/摘要 随着年龄的增长，认知能力的变化程度和变化速度存在相当大的个体差异。 我们越了解影响衰老是否以及如何影响大脑结构的生物学机制 和功能，我们就越有能力以针对个人的方式进行有效干预。总体 这项更新申请的目标是更好地了解炎症，血管，神经退行性疾病， 生活方式/行为对大脑老化轨迹中这种临床重要多样性的贡献。我们建议 继续跟踪我们的250名功能完整的老年正常人的深度表型队列， 在另外两个时间点上进行认知、神经成像和生物测定表征。我们的首要目标是定义 生物学和生活方式变量影响年龄相关性下降的独立和交互途径 我们的第二个目标是确定创新的血浆标记物的预测价值， 与阿尔茨海默氏症和神经退化有关的蛋白质。我们的第三个目标将包括创新， 客观、实时地测量睡眠和身体活动。实现这些目标将具有高度的 对外地产生重大影响。验证病理学的血浆生物标志物并阐明复杂的相互作用 影响大脑老化轨迹的因素将导致更好的预测和预防不良大脑 老龄化，并告知针对个人的干预措施。

项目成果

Visuospatial Functioning in the Primary Progressive Aphasias.

• DOI: 10.1017/s1355617717000984
• 发表时间: 2018-03
• 期刊: Journal of the International Neuropsychological Society : JINS
• 作者: Watson CL;Possin K;Allen IE;Hubbard HI;Meyer M;Welch AE;Rabinovici GD;Rosen H;Rankin KP;Miller Z;Santos-Santos MA;Kramer JH;Miller BL;Gorno-Tempini ML
• 通讯作者: Gorno-Tempini ML

Detecting Alzheimer's disease biomarkers with a brief tablet-based cognitive battery: sensitivity to Aβ and tau PET.

• DOI: 10.1186/s13195-021-00776-w
• 发表时间: 2021-02-08
• 期刊: Alzheimer's research & therapy
• 作者: Tsoy E;Strom A;Iaccarino L;Erlhoff SJ;Goode CA;Rodriguez AM;Rabinovici GD;Miller BL;Kramer JH;Rankin KP;La Joie R;Possin KL
• 通讯作者: Possin KL

Specific cortical and subcortical grey matter regions are associated with insomnia severity.

• DOI: 10.1371/journal.pone.0252076
• 发表时间: 2021
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Falgàs N;Illán-Gala I;Allen IE;Mumford P;Essanaa YM;Le MM;You M;Grinberg LT;Rosen HJ;Neylan TC;Kramer JH;Walsh CM
• 通讯作者: Walsh CM

Validating the Chinese version of the Verbal Learning Test for screening Alzheimer's disease.

• DOI: 10.1017/s1355617709991184
• 发表时间: 2010-03
• 期刊: JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY
• 影响因子: 2.6
• 作者: Chang, Chiung Chih;Kramer, Joel H.;Lin, Ker Neng;Chang, Wen Neng;Wang, Ya-Ling;Huang, Chi-Wei;Lin, Yu Ting;Chen, Ching;Wang, Pei Ning
• 通讯作者: Wang, Pei Ning

Gender modulates the APOE ε4 effect in healthy older adults: convergent evidence from functional brain connectivity and spinal fluid tau levels.

• DOI: 10.1523/jneurosci.0305-12.2012
• 发表时间: 2012-06-13
• 期刊: The Journal of neuroscience : the official journal of the Society for Neuroscience
• 作者: Damoiseaux JS;Seeley WW;Zhou J;Shirer WR;Coppola G;Karydas A;Rosen HJ;Miller BL;Kramer JH;Greicius MD;Alzheimer's Disease Neuroimaging Initiative
• 通讯作者: Alzheimer's Disease Neuroimaging Initiative