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Core B: Clinical Core

核心 B：临床核心

基本信息

批准号：
10647904
负责人：
JOEL H KRAMER
金额：
$ 154.06万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-05-01 至 2024-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10647904
关键词：
Acceleration Age Age of Onset Aging Amyloid Area Autopsy Biological Markers Biopsy Caregivers Chinese Chinese American Clinical Clinical Data Clinical Research Clinical Trials Clinical assessments Cognition Collection Communities Consent Creutzfeldt-Jakob Syndrome DNA Data Set Dementia Development Diagnostic Differential Diagnosis Dimensions Disease Early Diagnosis Education Emotions Enrollment Ensure Ethnic Origin Event Evolution Exposure to Family Frontotemporal Dementia Frontotemporal Lobar Degenerations Funding Genetic Goals Grant Health Heterogeneity Human Resources Image Individual International Intervention K-Series Research Career Programs Latino Leadership Life Style Magnetic Resonance Imaging Measures Methods Mission Molecular Motor Mutation Nerve Degeneration Neurodegenerative Disorders Participant Patients Phenotype Plasma Play Positron-Emission Tomography Prion Diseases Publications RNA Recording of previous events Registries Research Research Project Grants Research Subjects Research Support Research Training Resources Risk Risk Factors Role Rotation San Francisco Serum Skin Social Functioning Socioeconomic Status Specialized Center Tablets Training Programs Underrepresented Populations Work accurate diagnosis brain magnetic resonance imaging caregiving research clinical phenotype cognitive function cohort data acquisition data standards demented demographics design education research emotional functioning improved innovation member mild cognitive impairment molecular subtypes multidisciplinary neuroimaging novel novel strategies outreach outreach program programs psychologic recruit social social cognition tau Proteins underserved minority

项目摘要

ABSTRACT The overarching goal of the Clinical Core is to establish and maintain a clinical program that provides valuable, well-documented resources for cutting-edge clinical research for both the UCSF ADRC personnel and the wider scientific community. Our specific aims are to 1) Recruit and maintain cohorts of normal controls, MCI subjects with underlying AD or an FTD-spectrum disorder, and mildly demented subjects with underlying AD or an FTD-spectrum or prion disorders. These cohorts will include Chinese-American and Latino subjects; 2) Carry out extensive and deep phenotyping of these subjects, including social, motor, and cognitive function, plus measures of lifestyle, educational and health histories, and socioeconomic status; 3) Provide clinical data and well characterized subjects for research on aging and dementia to the larger research community; and 4) Support research training.

摘要临床核心的总体目标是建立和维护一个临床项目，有据可查的资源，为UCSF ADRC人员和更广泛的科学界。我们的具体目标是：1）招募和维持正常对照组，MCI 患有基础AD或FTD谱系障碍的受试者，以及患有基础AD或 FTD谱或朊病毒疾病这些队列将包括华裔美国人和拉丁裔受试者; 2)对这些受试者进行广泛而深入的表型分析，包括社会、运动和认知功能，加上生活方式、教育和健康史以及社会经济状况的测量; 3）提供临床数据以及对老龄化和痴呆症研究的良好表征的主题，以更大的研究社区;和4）支持研究培训。