ATTENTION AND EXECUTIVE FUNCTIONING IN FRONTOTEMPORAL DEMENTIA

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 研究中心，而研究中心不一定是研究者所在的机构。 该项目的总体目标是确定额颞叶痴呆（FTD）的注意力和执行功能障碍的特征和神经解剖学预测因子。FTD是一种对额叶有差异性影响的神经退行性疾病。额叶介导的注意力和执行功能缺陷是FTD的核心特征，对行为产生深远影响，包括认知僵化、抑制解除、无法维持目标导向行为以及在记忆、语言和空间能力相对保留的背景下功能适应不良。尽管他们的诊断和病人护理的重要性，这些注意力和执行缺陷是知之甚少。我们将使用注意力和执行功能的认知模型研究75例轻度FTD患者、75例严重程度匹配的AD患者和100例年龄匹配的对照组，这些模型能够将注意力解析为与前后网络相关的几个关键组成部分。具体目的是评价FTD、AD和对照组在注意力执行控制方面的差异，检测特定脑萎缩区域是否选择性与注意力任务受损相关，并评价FTD和AD中注意力和执行缺陷的功能意义。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The overall goal of this project is to define the characteristics and neuroanatomical predictors of attention and executive impairments in frontotemporal dementia (FTD). FTD is a neurodegenerative disorder that differentially affects the frontal lobes. Frontally mediated deficits in attention and executive functioning are central features of FTD that have far reaching consequences for behavior, including cognitive rigidity, disinhibition, inability to sustain goal-oriented behavior, and poor functional adaptation in the context of relative preservation of memory, language, and spatial ability. Despite their importance for diagnosis and patient care, these attentional and executive deficits are poorly understood. We will study 75 patients with mild FTD, 75 severity-matched patients with AD, and 100 age-matched controls using cognitive models of attention and executive functioning that enable parsing of attention into several key components associated with anterior and posterior networks. Specific aims are to evaluate differences between FTD, AD and controls in executive control of attention, test whether specific regions of cerebral atrophy are selectively associated with impairment on attentional tasks, and evaluate the functional significance of attentional and executive deficits in FTD and AD.