核心 B：临床核心-猫眼课题宝

核心 B：临床核心

批准号：

10431780

负责人：

JOEL H KRAMER

金额：

$184.36万

依托单位：

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

依托单位国家：

美国

项目类别：

财政年份：

2019

资助国家：

美国

项目状态：

已结题

起止时间：

2019-05-01 至 2024-03-31

来源：

https://reporter.nih.gov/project-details/10431780

关键词：

Age Age of Onset Aging Amyloid Area Autopsy Biological Markers Biopsy Caregivers Chinese Chinese American Clinical Clinical Data Clinical Research Clinical Trials Clinical assessments Cognition Cognitive Collection Communities Consent Creutzfeldt-Jakob Syndrome DNA Data Set Dementia Development Diagnostic Differential Diagnosis Disease Early Diagnosis Emotions Enrollment Ensure Event Evolution Exposure to Family Frontotemporal Dementia Funding Genetic Goals Grant Health Heterogeneity Human Resources Image Individual International Intervention K-Series Research Career Programs Latino Leadership Life Style Magnetic Resonance Imaging Measures Methods Mission Molecular Motor Mutation Nerve Degeneration Neurodegenerative Disorders Participant Patients Phenotype Plasma Play Positron-Emission Tomography Prion Diseases Publications RNA Recording of previous events Registries Research Research Project Grants Research Subjects Research Support Research Training Resources Risk Risk Factors Role Rotation Salvelinus San Francisco Skin Social Functioning Socioeconomic Status Specialized Center Tablets Training Programs Underrepresented Populations Work accurate diagnosis brain magnetic resonance imaging caregiving research clinical phenotype cognitive function cohort data acquisition data standards demented demographics design education research emotional functioning improved innovation member molecular subtypes multidisciplinary neuroimaging novel novel strategies outreach outreach program programs psychologic ranpirnase recruit social social cognition tau Proteins underserved minority

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ABSTRACT The overarching goal of the Clinical Core is to establish and maintain a clinical program that provides valuable, well-documented resources for cutting-edge clinical research for both the UCSF ADRC personnel and the wider scientific community. Our specific aims are to 1) Recruit and maintain cohorts of normal controls, MCI subjects with underlying AD or an FTD-spectrum disorder, and mildly demented subjects with underlying AD or an FTD-spectrum or prion disorders. These cohorts will include Chinese-American and Latino subjects; 2) Carry out extensive and deep phenotyping of these subjects, including social, motor, and cognitive function, plus measures of lifestyle, educational and health histories, and socioeconomic status; 3) Provide clinical data and well characterized subjects for research on aging and dementia to the larger research community; and 4) Support research training.

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