Core B: Clinical Core

摘要 临床核心的总体目标是建立和维护一个临床项目， 有据可查的资源，为UCSF ADRC人员和 更广泛的科学界。我们的具体目标是：1）招募和维持正常对照组，MCI 患有基础AD或FTD谱系障碍的受试者，以及患有基础AD或 FTD谱或朊病毒疾病这些队列将包括华裔美国人和拉丁裔受试者; 2)对这些受试者进行广泛而深入的表型分析，包括社会、运动和认知功能， 加上生活方式、教育和健康史以及社会经济状况的测量; 3）提供临床数据 以及对老龄化和痴呆症研究的良好表征的主题，以更大的研究社区;和4） 支持研究培训。

ABSTRACT The overarching goal of the Clinical Core is to establish and maintain a clinical program that provides valuable, well-documented resources for cutting-edge clinical research for both the UCSF ADRC personnel and the wider scientific community. Our specific aims are to 1) Recruit and maintain cohorts of normal controls, MCI subjects with underlying AD or an FTD-spectrum disorder, and mildly demented subjects with underlying AD or an FTD-spectrum or prion disorders. These cohorts will include Chinese-American and Latino subjects; 2) Carry out extensive and deep phenotyping of these subjects, including social, motor, and cognitive function, plus measures of lifestyle, educational and health histories, and socioeconomic status; 3) Provide clinical data and well characterized subjects for research on aging and dementia to the larger research community; and 4) Support research training.