Core B: Clinical Core

摘要 临床核心的首要目标是建立和维护一个临床项目，提供有价值的， 为加州大学旧金山分校ADRC人员和 更广泛的科学界。我们的具体目标是1)招募和维持正常对照队列，MCI 患有潜在AD或FTD谱系障碍的受试者，以及患有潜在AD或 一种FTD谱系或普恩病症。这些群体将包括华裔美国人和拉美裔美国人； 2)对这些受试者进行广泛和深入的表型鉴定，包括社交、运动和认知功能， 外加对生活方式、教育和健康历史以及社会经济状况的衡量；3)提供临床数据 以及面向更大的研究界的老龄化和痴呆症研究的特点良好的主题；以及4) 支持研究培训。

ABSTRACT The overarching goal of the Clinical Core is to establish and maintain a clinical program that provides valuable, well-documented resources for cutting-edge clinical research for both the UCSF ADRC personnel and the wider scientific community. Our specific aims are to 1) Recruit and maintain cohorts of normal controls, MCI subjects with underlying AD or an FTD-spectrum disorder, and mildly demented subjects with underlying AD or an FTD-spectrum or prion disorders. These cohorts will include Chinese-American and Latino subjects; 2) Carry out extensive and deep phenotyping of these subjects, including social, motor, and cognitive function, plus measures of lifestyle, educational and health histories, and socioeconomic status; 3) Provide clinical data and well characterized subjects for research on aging and dementia to the larger research community; and 4) Support research training.