权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Novel Imaging and Biofluid Biomarkers of Small Vessel Cerebrovascular Disease

小血管脑血管疾病的新型成像和生物流体生物标志物

基本信息

批准号：
10369292
负责人：
JOEL H KRAMER
金额：
$ 254.76万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-09-30 至 2023-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10369292
关键词：
Address Age Aging Alzheimer&apos s Disease Alzheimer&apos s disease risk Behavioral Biological Biological Markers Biological Models Blood Vessels California Censuses Cerebrovascular Disorders Cerebrovascular system Clinical Clinical Sciences Clinical Trials Cognition Cognitive Collaborations Data Dementia Development Diagnosis Diffusion Disease Disease Pathway Early Diagnosis Elderly Endothelium Enrollment Foundations Functional disorder Goals Head Image Impaired cognition Individual Infrastructure Injury Laboratories Lead Leadership Liquid substance Longitudinal Studies Magnetic Resonance Imaging Measures Modeling Molecular Monitor Multi-site clinical study National Institute of Neurological Disorders and Stroke Neurology Neuropsychology Outcome Pathology Pathway interactions Patients Phase Phenotype Plasma Population Heterogeneity Prognosis Protocols documentation Psychometrics Public Health Reproducibility Research Sampling Scientist Signal Transduction Site Specific qualifier value Statistical Models Techniques Testing Time Treatment Efficacy Universities Validation Vascular Diseases Work base biomarker development cerebrovascular clinical phenotype cognitive change cognitive function cohort coronavirus disease exosome experience follow-up functional decline image processing improved innovation member mild cognitive impairment neuroimaging novel outcome prediction personalized medicine precision medicine professor recruit tool validation studies vascular cognitive impairment and dementia white matter

项目摘要

PROJECT SUMMARY/ABSTRACT Small vessel cerebrovascular disease is common in the elderly and is a well-known contributor to cognitive decline. A major gap in the field, however, is the ongoing need for reliable and reproducible biologic markers of vascular disease suitable for early detection, disease monitoring, and measuring treatment efficacy. The overarching goal of this proposal is to clinically validate novel neuroimaging and fluid-based biomarkers of a cerebrovascular disease selected by the NINDs and developed during the first five years of the MarkVCID consortium. We propose to longitudinally follow a cohort of 200 diverse, older subjects who present with a range of cerebrovascular burdens and cognitive complaints, and functional decline. Our aims are to validate the MarkVCID biomarkers and address possible interactions between these biomarkers and Alzheimer’s disease pathophysiology. Accomplishing these goals will improve the early detection, diagnosis, and prognosis of small vessel cerebrovascular disease in older subjects and provide better targets and outcome metrics for clinical trials.

项目总结/摘要小血管脑血管疾病在老年人中很常见，并且是众所周知的认知能力下降的原因。然而，该领域的一个主要差距是持续需要适用于早期检测、疾病监测和测量治疗效果的可靠且可重复的血管疾病生物标志物。该提案的总体目标是临床验证NIND选择的脑血管疾病的新型神经影像学和基于液体的生物标志物，这些生物标志物是在MarkVCID联盟的前五年开发的。我们建议纵向跟踪200名不同的老年受试者队列，这些受试者存在一系列脑血管负担、认知主诉和功能下降。我们的目标是验证MarkVCID生物标志物，并解决这些生物标志物和阿尔茨海默病病理生理学之间可能的相互作用。实现这些目标将改善老年受试者小血管脑血管病的早期检测、诊断和预后，并为临床试验提供更好的目标和结局指标。