Novel Imaging and Biofluid Biomarkers of Small Vessel Cerebrovascular Disease

项目摘要/摘要 小血管脑血管疾病在老年人中很常见，是认知能力下降的一个众所周知的因素。然而，该领域的一个主要空白是对适用于早期发现、疾病监测和衡量治疗效果的可靠和可重复的血管疾病生物标志物的持续需求。这项建议的首要目标是在临床上验证NINDS选择的脑血管疾病的新型神经成像和基于液体的生物标记物，并在MarkVCID财团的头五年内开发。我们建议对200名不同的老年受试者进行纵向追踪，这些受试者表现出一系列脑血管负担、认知症状和功能衰退。我们的目标是验证MarkVCID生物标记物，并解决这些生物标记物与阿尔茨海默病病理生理学之间可能存在的相互作用。实现这些目标将改善老年人小血管脑血管疾病的早期发现、诊断和预后，并为临床试验提供更好的靶点和结果指标。

PROJECT SUMMARY/ABSTRACT Small vessel cerebrovascular disease is common in the elderly and is a well-known contributor to cognitive decline. A major gap in the field, however, is the ongoing need for reliable and reproducible biologic markers of vascular disease suitable for early detection, disease monitoring, and measuring treatment efficacy. The overarching goal of this proposal is to clinically validate novel neuroimaging and fluid-based biomarkers of a cerebrovascular disease selected by the NINDs and developed during the first five years of the MarkVCID consortium. We propose to longitudinally follow a cohort of 200 diverse, older subjects who present with a range of cerebrovascular burdens and cognitive complaints, and functional decline. Our aims are to validate the MarkVCID biomarkers and address possible interactions between these biomarkers and Alzheimer’s disease pathophysiology. Accomplishing these goals will improve the early detection, diagnosis, and prognosis of small vessel cerebrovascular disease in older subjects and provide better targets and outcome metrics for clinical trials.