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Updated confocal microscope in the Imaging Core facility to support biomedical research

更新了成像核心设施中的共焦显微镜以支持生物医学研究

基本信息

批准号：
10400322
负责人：
MELISSA A HARRINGTON
金额：
$ 24.98万
依托单位：
DELAWARE STATE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-09-26 至 2023-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10400322
关键词：
Address Biomedical Research Brain Brain Diseases Cells Confocal Microscopy Core Facility Data Delaware Development Educational Activities Equipment Faculty Funding Future Generations Head Health Historically Black Colleges and Universities Human Image Investments Legal patent Microscope Microscopy National Institute of General Medical Sciences Neurosciences Neurosciences Research Noise Optics Research Research Activity Research Infrastructure Research Personnel Research Training Resolution Scientific Advances and Accomplishments Services Signal Transduction System Technology Time United States National Institutes of Health Universities Update bioimaging community based participatory research experience imaging facilities improved innovation instrumentation nervous system disorder optical imaging programs quantitative imaging temporal measurement undergraduate research undergraduate student

项目摘要

Core Facility Equipment Supplement to P20GM103653 Summary Neuroscience-Center affiliated faculty at Delaware State University are also major users of the OSCAR Imaging Core Facility that is supported by the Delaware INBRE. However, the two confocal microscopes currently operating in the facility date from the previous century, and the slow rate at which image data are collected limits their application for live-cell and quantitative imaging and limit the research questions that faculty can address using those microscopes. The acquisition of a spinning-disk system confocal microscope will enhance and strengthen significantly the research and educational activities at Delaware State University (DSU), a primarily undergraduate and Historically-Black university. The patented spinning-disk system will bring a significant improvement in confocal and time-lapse microscopy with better spatial- resolution, temporal-resolution, and improved signal-to-noise ratios for high-resolution bioimaging. The microscope will be installed in the OSCAR Imaging Facility, a multi-user shared facility, allowing diverse pool of users to access this advanced technology. We will acquire a Voxyl Spinning-Disk system (V3 confocal head and accessories) with NIGMS supplement funds, and an IX83 Olympus inverted microscope (microscope stand and accessories) with DSU institutional funds, which will be assembled to build a high-resolution confocal microscope. The assembly will be directed by Dr. Boukari, an optical physicist with extensive experience in optical and imaging instrumentation who serves as the director of the OSCAR Imaging Core. Dr. Boukari has previously assembled a similar microscope while he was working at NIH. He will be assisted by our Core Facility Manager, who has 10 years of experience using and maintaining confocal microscopes. Funding of this supplement will allow DSU to leverage our institutional funds and the expertise and know-how of our Imaging Facility staff to “bootstrap” our way to making cutting edge technology confocal microscopy available to our neuroscience and biomedical researchers. By assembling the system ourselves we will save more than $150,000 compared to purchasing a turn-key system.

P20GM103653的核心设施设备补充总结特拉华州州立大学的神经科学中心附属教师也 OSCAR成像核心设施的主要用户，特拉华州INBRE。然而，目前运行的两台共焦显微镜在设施日期从上个世纪，和缓慢的速度，收集的数据限制了它们在活细胞和定量成像中的应用并限制了教师可以使用这些显微镜解决的研究问题。获得一个转盘系统共聚焦显微镜将大大提高和加强研究和教育活动，特拉华州州立大学（DSU），主要是本科和历史上的黑人大学。专利旋转盘系统将使共焦和延时显微镜技术得到显著的改进，分辨率、时间分辨率和用于高分辨率生物成像的改善的信噪比。显微镜将安装在OSCAR成像设施中，这是一个多用户共享设施，允许不同的用户访问这种先进的技术。我们将获得一个Voxyl旋转盘系统（V3共焦头和配件）与NIGMS 一台IX83 Olympus倒置显微镜（显微镜支架和配件）， DSU机构基金，将被组装，以建立一个高分辨率的共聚焦显微镜。的组装将由布卡里博士指导，布卡里博士是一位光学物理学家，在光学和他是OSCAR成像核心的主任。布卡里博士他之前在NIH工作时组装了一个类似的显微镜。我们的核心会协助他设备经理，拥有10年使用和维护共聚焦显微镜的经验。供资这一补充将使DSU能够利用我们的机构资金以及我们成像部门的专业知识和技术设施工作人员“引导”我们的方式，使尖端技术共聚焦显微镜提供给我们的神经科学和生物医学研究人员。通过自己组装该系统，我们将节省15万多美元与购买交钥匙系统相比。

项目成果

期刊论文数量（190）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Is the Political Slant of Psychology Research Related to Scientific Replicability?

DOI：
10.1177/1745691620924463
发表时间：
2019-02
期刊：
Perspectives on Psychological Science
影响因子：
12.6
作者：
Diego A. Reinero;J. Wills;W. Brady;P. Mende-Siedlecki;Jarret T. Crawford;J. V. Van Bavel
通讯作者：
Diego A. Reinero;J. Wills;W. Brady;P. Mende-Siedlecki;Jarret T. Crawford;J. V. Van Bavel

Examination of cortically projecting cholinergic neurons following exercise and environmental intervention in a rodent model of fetal alcohol spectrum disorders.