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Core A (Administrative/Bioinformatics/Statistics)

核心A（管理/生物信息学/统计学）

基本信息

批准号：
10421278
负责人：
BERT W O'MALLEY
金额：
$ 7.93万
依托单位：
BAYLOR COLLEGE OF MEDICINE
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-07-01 至 2024-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10421278
关键词：
Administrative Personnel Administrator Animals Area Atlases Bioinformatics Biological Biological Assay ChIP-seq Computer Hardware Computer software Core Facility DNA Data Data Analyses Data Storage and Retrieval Deposition Engineering Financial Support Funding Mechanisms Gene Expression Grant Guidelines Human Infrastructure International Maintenance Mediator of activation protein Medicine Metabolism Molecular and Cellular Biology Monitor Multiomic Data National Institute of Diabetes and Digestive and Kidney Diseases Nuclear Receptors Occupational activity of managing finances Office of Administrative Management Policies Program Research Project Grants Proteomics Publications Receptor Signaling Research Research Priority Resolution Series Services Software Tools System United States National Institutes of Health Visualization Wages Work career networking college computer network cost data acquisition data dissemination data integration data repository data sharing data submission data visualization epigenome epigenomics experience insight metabolomics online repository operation professor programs repository statistics support network transcriptome sequencing transcriptomics web-based informatics

项目摘要

Core A (Administrative Core) - Project Summary All research projects of this Program Project (PP) will rely on the use of administrative, bioinformatics and statistical support, which will be directed by Core A. The Administrative Component of Core A will provide centralized scientific, administrative and financial management as well as computer hardware, software and network support services (which includes data sharing, storage, and maintenance). The Administrative Component of Core A will be responsible for monitoring the research progress attained by Projects 1-4 as well as the efficient use of Core B by each of the four projects. Core A also will be responsible for general support of cost areas common to Projects 1-4 and Cores A-B. The Bioinformatics and Statistics Component of Core A will integrate both data generated from Projects 1-4 as well as publicly available data across a continuum of assays ranging from cistromics (via ChIP-Seq), transcriptomics (via RNA-Seq/microarray), proteomics (RPPA and DNA-IP), and metabolomics (via mass spec platforms). Data acquisition will occur in established core facilities currently in place within the Department of Molecular and Cellular Biology at Baylor College of Medicine. The Bioinformatics and Statistics Component of Core A will perform primary data analysis, extracting significant features from each series of OMICs assays proposed in Projects 1-4. The major contribution of the Bioinformatics and Statistics Component of Core A consists of integrative analysis, wherein data from multiple OMICs platforms are combined, leading to comprehensive biological insight and testable hypotheses. Core A will use data from Encode, the NIH Epigenomic Roadmap, International Human Epigenome Consortium (IHEC), and scientific data repositories such as the NIH Gene Expression Omnibus (GEO) and Nuclear Receptor Signaling Atlas (NURSA). For scientific publications, Core A will generate visualizations of these data and results by employing both off-line and online software tools. To meet data dissemination guidelines, Core A will perform data deposition to the appropriate repositories, including but not limited to the NIDDK sponsored NURSA. Collectively, these efforts will provide the necessary infrastructure to support the various research and core components of this Program Project application. The successful operation of this administrative team is unparalleled and is essential to completion of the overarching scientific objectives of our integrative research teams.

核心A（行政核心）——项目总结