Center for Reproductive Biological Research

生殖生物学研究中心

• 批准号: 7931854
• 负责人: BERT W O'MALLEY
• 金额: $ 3.5万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-30 至 2010-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7931854
• 关键词: Center; Reproductive; Biological; Research

DESCRIPTION (provided by applicant): The Center for Reproductive Biology Research has served the scientific community for 35 years - first as a P30 Center, then over 10 years as a U54 SCCPIR Grant. The theme chosen and approved for the renewal application is "Mechanisms Regulating Endometrial Function and Dysfunction and Impact on Ovarian Function". The Center's purpose is to establish a comprehensive research and training program to investigate the molecular mechanisms governing female reproduction in mice and humans. Research will be accomplished by four projects: Project I: "Endometrial Steroid Receptor Coregulator-2 in Peri-implantation Biology" will investigate the role of nuclear receptor coregulators in endometrial function. Project II: "Cellular Signals in Ovulation and Luteinization" will investigate the impact of endometrial inflammation on ovarian function. Project III: "MicroRNAs in Endometrial Function and Dysfunction" will identify novel microRNAs altered in endometriosis and investigate their biology. Project IV: "Role of the Orphan Nuclear Receptor COUPTF-II in Endometrial Biology" will determine mechanisms of nuclear receptor and growth factor regulation of endometrial function. Research projects are supported by 4 Cores: Administrative/Bioinformatics Core (A); Animal Core (B); Cell and Tissue Culture Core (C); and Integrated Microscopy Core (D). The Administrative Core will provide the Center with centralized management and centralized data analysis. The Animal Core will centralize the technology and resources required in the use of all in vivo models. The Cell Culture Core will provide investigators with specific reagents for the culture of primary cells and cell lines, as well as the expertise required to manipulate these cells. The Integrated Microscopy Core will aid investigators in the histological, immuno-histochemical and ultrastructural analysis required for the execution of their projects. Finally, the Center will support a Pilot Project to allow exploration of new areas of research, especially those that will translate findings to human clinical research. Thus, this Center for Reproductive Biology Research application will combine basic and translational research approaches to investigate the molecular mechanisms for regulation of female reproduction and fertility in animals and humans and foster the training of investigators in the field of reproductive biology.

描述(由申请人提供)：生殖生物学研究中心已经为科学界服务了35年--最初是作为P30中心，然后是10多年的U54 SCCPIR补助金。选择并批准续展申请的主题是：“子宫内膜功能和功能障碍的调节机制及其对卵巢功能的影响”。该中心的目的是建立一个全面的研究和培训计划，以研究控制老鼠和人类雌性生殖的分子机制。研究将由四个项目完成：项目I：《子宫内膜类固醇受体辅调节因子-2在围着床期生物学中的作用》将研究核受体辅调节因子在子宫内膜功能中的作用。项目II：《排卵和黄体形成过程中的细胞信号》将研究子宫内膜炎症对卵巢功能的影响。项目III：“子宫内膜功能和功能障碍中的microRNAs”将识别子宫内膜异位症中改变的新microRNAs，并研究它们的生物学。项目四：“孤儿核受体COUPTF-II在子宫内膜生物学中的作用”将确定核受体和生长因子调节子宫内膜功能的机制。研究项目得到4个核心的支持：行政/生物信息学核心(A)；动物核心(B)；细胞和组织培养核心(C)；以及综合显微镜核心(D)。行政核心将为中心提供集中管理和集中数据分析。动物核心将集中使用所有活体模型所需的技术和资源。细胞培养核心将为研究人员提供培养原代细胞和细胞系的特定试剂，以及操纵这些细胞所需的专业知识。综合显微镜核心将协助研究人员进行执行其项目所需的组织学、免疫组织化学和超微结构分析。最后，该中心将支持一个试点项目，以便探索新的研究领域，特别是那些将发现转化为人类临床研究的领域。因此，生殖生物学研究应用中心将结合基础研究和翻译研究方法，研究动物和人类中女性生殖和生育调节的分子机制，并促进生殖生物学领域的研究人员的培训。