Medical Student Training Program

医学生培训计划

• 批准号: 10440049
• 负责人: ROBERT LEVENSON
• 金额: $ 5.38万
• 依托单位: PENNSYLVANIA STATE UNIV HERSHEY MED CTR
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-07-01 至 2022-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10440049
• 关键词: Medical Students; Training Programs

 DESCRIPTION (provided by applicant): This application requests MSTP funding for the Penn State MD/PhD Program. Our program has a 20-year history of training outstanding students and providing them with the tools and experiences needed to become successful physician-scientists and leaders in academic medicine. Penn State has a talented and interactive faculty committed to biomedical research and MD/PhD career development. The students enrolled in our MD/PhD program are fully supported by the Dean of the College of Medicine during the medical school years and by faculty grants and individual fellowships during the graduate phase of the program. An MSTP award would leverage this institutional commitment, allowing us to increase the program from our current level of 6 students admitted per year to 8 students admitted per year. Over the past 10 years, Penn State has substantially improved the quality of the MD/PhD program through several targeted investments: (i) full autonomy of the MD/PhD program to select and admit qualified students; (ii) ~100% increase in institutional support, from less than $1 million to nearly $2 million per year; (iii) recruitment of >70 physician-scientist faculty members, including several departmental chairs and program directors, plus a recent initiative to recruit an additional 5-10 new physician-scientist faculty members; (iv) a 45% increase in the applicant pool size; (v) an increase in the number of matriculating students from 33 to 51; (vi) a doubling of the number of matriculated underrepresented minority students; and (vii) establishment of closer ties with our sister campus at University Park (UP) through the development of joint programs with Engineering Sciences & Mechanics and Molecular & Cellular Integrated Biosciences, as well as the appointment of an Associate Director of the MD/PhD program on the UP campus. The curriculum for the MD/PhD program is interdisciplinary and integrated. Students are exposed to both clinical and basic scientific activities longitudinally throughout their training, thus emphasizing the need to integrate biomedical research with patient care. MD/PhD-specific programmatic activities include a monthly seminar series where students present their own research and learn from visiting speakers; a bimonthly Clinical Research Conference where students learn to use clinical problems as a springboard for investigating the basic and translational sciences literature; a longitudinal Clinical Exposure Program, in which students hone their clinical skills by selecting a clinical preceptor and attending clinic at least one half day per month while pursuing their research; an annual retreat held on the UP campus; and several courses and seminars that specifically deal with translational biomedical research and MD/PhD career development. Most importantly, Program leaders use a very hands-on approach with our students. We take mentorship extremely seriously and we invest a significant amount of time meeting with and listening to our students to make their training experience at Penn State one that will not only be rigorous, but also provide a training path that fosters their career development, enabling them to excel in their future careers as physician-scientists.

 描述（由申请人提供）：本申请请求宾夕法尼亚州立大学医学博士/博士项目的 MSTP 资助。我们的项目拥有 20 年的历史，致力于培养优秀的学生，为他们提供成为成功的医师科学家和医学学术领导者所需的工具和经验。宾夕法尼亚州立大学拥有一支才华横溢且互动的教师队伍，致力于生物医学研究和医学博士/博士职业发展。就读我们的医学博士/博士课程的学生在医学院期间得到医学院院长的全力支持，并在该课程的研究生阶段得到教师助学金和个人奖学金。 MSTP 奖项将利用这一机构承诺，使我们能够将该项目从目前每年录取 6 名学生的水平增加到每年 8 名学生。在过去的10年里，宾夕法尼亚州立大学通过多项有针对性的投资，大幅提高了MD/PhD项目的质量：（i）MD/PhD项目在选拔和录取合格学生方面拥有完全自主权； (ii) 机构支持增加约 100%，从每年不到 100 万美元增加到近 200 万美元； (iii) 招聘超过 70 名医师-科学家教职人员，包括几位系主任和项目主任，以及最近招募 5-10 名新医师-科学家教职人员的举措； (iv) 申请人池规模增加 45%； (v) 入学学生人数从 33 人增加到 51 人； ㈥ 被录取的少数族裔学生人数增加一倍； (vii) 通过与工程科学与力学和分子与细胞集成生物科学开发联合项目，以及在 UP 校园任命医学博士/博士项目副主任，与大学公园 (UP) 姐妹校区建立更密切的联系。医学博士/博士课程的课程是跨学科的、综合性的。学生在整个培训过程中纵向接触临床和基础科学活动，从而强调将生物医学研究与患者护理相结合的必要性。 MD/PhD 特定的计划活动包括每月一次的研讨会系列，学生可以在其中展示自己的研究成果并向来访的演讲者学习；每两个月一次的临床研究会议，学生们学习如何利用临床问题作为研究基础和转化科学文献的跳板；纵向临床暴露计划，学生通过选择一个项目来磨练他们的临床技能 在进行研究的同时，担任临床导师并每月至少有半天时间到诊所就诊；在 UP 校园举办的年度静修活动；以及一些专门针对转化生物医学研究和医学博士/博士职业发展的课程和研讨会。最重要的是，项目负责人对我们的学生采用非常实践的方法。我们非常重视指导，并投入大量时间与学生会面并倾听他们的意见，使他们在宾夕法尼亚州立大学的培训经历不仅是一种 严格的，但也提供了促进他们职业发展的培训路径，使他们能够在未来作为医生科学家的职业生涯中脱颖而出。

项目成果

Induction of store-operated calcium entry (SOCE) suppresses glioblastoma growth by inhibiting the Hippo pathway transcriptional coactivators YAP/TAZ.

• DOI: 10.1038/s41388-018-0425-7
• 发表时间: 2019-01
• 期刊: Oncogene
• 影响因子: 8
• 作者: Liu Z;Wei Y;Zhang L;Yee PP;Johnson M;Zhang X;Gulley M;Atkinson JM;Trebak M;Wang HG;Li W
• 通讯作者: Li W

Construction and Application of Polygenic Risk Scores in Autoimmune Diseases.

• DOI: 10.3389/fimmu.2022.889296
• 发表时间: 2022
• 期刊: Frontiers in immunology
• 影响因子: 7.3

Neutrophil-induced ferroptosis promotes tumor necrosis in glioblastoma progression.

• DOI: 10.1038/s41467-020-19193-y
• 发表时间: 2020-10-27
• 期刊: Nature communications
• 影响因子: 16.6
• 作者: Yee PP;Wei Y;Kim SY;Lu T;Chih SY;Lawson C;Tang M;Liu Z;Anderson B;Thamburaj K;Young MM;Aregawi DG;Glantz MJ;Zacharia BE;Specht CS;Wang HG;Li W
• 通讯作者: Li W

Tumor necrosis: A synergistic consequence of metabolic stress and inflammation.

• DOI: 10.1002/bies.202100029
• 发表时间: 2021-07
• 期刊: BioEssays : news and reviews in molecular, cellular and developmental biology
• 作者: Yee PP;Li W
• 通讯作者: Li W