Medical Student Training Program

医学生培训计划

• 批准号: 10440049
• 负责人: ROBERT LEVENSON
• 金额: $ 5.38万
• 依托单位: PENNSYLVANIA STATE UNIV HERSHEY MED CTR
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-07-01 至 2022-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10440049
• 关键词: Medical Students; Training Programs

 DESCRIPTION (provided by applicant): This application requests MSTP funding for the Penn State MD/PhD Program. Our program has a 20-year history of training outstanding students and providing them with the tools and experiences needed to become successful physician-scientists and leaders in academic medicine. Penn State has a talented and interactive faculty committed to biomedical research and MD/PhD career development. The students enrolled in our MD/PhD program are fully supported by the Dean of the College of Medicine during the medical school years and by faculty grants and individual fellowships during the graduate phase of the program. An MSTP award would leverage this institutional commitment, allowing us to increase the program from our current level of 6 students admitted per year to 8 students admitted per year. Over the past 10 years, Penn State has substantially improved the quality of the MD/PhD program through several targeted investments: (i) full autonomy of the MD/PhD program to select and admit qualified students; (ii) ~100% increase in institutional support, from less than $1 million to nearly $2 million per year; (iii) recruitment of >70 physician-scientist faculty members, including several departmental chairs and program directors, plus a recent initiative to recruit an additional 5-10 new physician-scientist faculty members; (iv) a 45% increase in the applicant pool size; (v) an increase in the number of matriculating students from 33 to 51; (vi) a doubling of the number of matriculated underrepresented minority students; and (vii) establishment of closer ties with our sister campus at University Park (UP) through the development of joint programs with Engineering Sciences & Mechanics and Molecular & Cellular Integrated Biosciences, as well as the appointment of an Associate Director of the MD/PhD program on the UP campus. The curriculum for the MD/PhD program is interdisciplinary and integrated. Students are exposed to both clinical and basic scientific activities longitudinally throughout their training, thus emphasizing the need to integrate biomedical research with patient care. MD/PhD-specific programmatic activities include a monthly seminar series where students present their own research and learn from visiting speakers; a bimonthly Clinical Research Conference where students learn to use clinical problems as a springboard for investigating the basic and translational sciences literature; a longitudinal Clinical Exposure Program, in which students hone their clinical skills by selecting a clinical preceptor and attending clinic at least one half day per month while pursuing their research; an annual retreat held on the UP campus; and several courses and seminars that specifically deal with translational biomedical research and MD/PhD career development. Most importantly, Program leaders use a very hands-on approach with our students. We take mentorship extremely seriously and we invest a significant amount of time meeting with and listening to our students to make their training experience at Penn State one that will not only be rigorous, but also provide a training path that fosters their career development, enabling them to excel in their future careers as physician-scientists.

 描述（由申请人提供）：本申请要求MSTP资助宾夕法尼亚州立大学MD/PhD计划。我们的计划有培养优秀学生的20年历史，并为他们提供成为成功的医生科学家和学术医学领导者所需的工具和经验。宾夕法尼亚州立大学拥有一支才华横溢且互动的教师队伍，致力于生物医学研究和医学博士/博士职业发展。就读于我们的MD/博士课程的学生在医学院期间得到医学院院长的全力支持，并在该计划的研究生阶段得到教师赠款和个人奖学金的支持。MSTP奖将利用这一机构的承诺，使我们能够从我们目前的水平，每年录取6名学生增加到每年录取8名学生的计划。在过去的10年里，宾夕法尼亚州立大学通过几项有针对性的投资大大提高了MD/PhD课程的质量：（i）MD/PhD课程完全自主选择和录取合格的学生;（ii）机构支持增加100%，从每年不到100万美元增加到近200万美元;（iii）招募超过70名医生-科学家教职员工，包括几名系主任和项目主任，以及最近招募另外5-10名新医生-科学家教职员工的举措;（iv）申请人人数增加45%; ㈤入学人数从33人增加到51人; ㈥入学人数不足的少数民族学生人数增加一倍;和（vii）通过与工程科学与力学和分子与细胞综合生物科学的联合项目的发展，与我们在大学公园（UP）的姐妹校园建立更紧密的联系，以及在UP校园的MD/博士课程的副主任的任命。MD/PhD课程是跨学科和综合的。学生在整个培训过程中纵向接触临床和基础科学活动，从而强调将生物医学研究与患者护理相结合的必要性。MD/PhD特定的计划活动包括每月一次的研讨会系列，学生展示自己的研究并从来访的演讲者那里学习;双月临床研究会议，学生学习使用临床问题作为调查基础和转化科学文献的跳板;纵向临床暴露计划，学生通过选择一个 临床导师和参加诊所每月至少半天，同时追求他们的研究;在UP校园举行的年度务虚会;以及专门处理转化生物医学研究和MD/博士职业发展的几个课程和研讨会。最重要的是，项目负责人对我们的学生使用非常实际的方法。我们非常认真地对待导师制，我们投入了大量的时间与学生会面并倾听他们的意见，使他们在宾夕法尼亚州立大学的培训经历不仅 严格，但也提供了一个培训途径，促进他们的职业发展，使他们能够在未来的职业生涯中脱颖而出，作为医生科学家。

项目成果

Induction of store-operated calcium entry (SOCE) suppresses glioblastoma growth by inhibiting the Hippo pathway transcriptional coactivators YAP/TAZ.

• DOI: 10.1038/s41388-018-0425-7
• 发表时间: 2019-01
• 期刊: Oncogene
• 影响因子: 8
• 作者: Liu Z;Wei Y;Zhang L;Yee PP;Johnson M;Zhang X;Gulley M;Atkinson JM;Trebak M;Wang HG;Li W
• 通讯作者: Li W

Construction and Application of Polygenic Risk Scores in Autoimmune Diseases.

• DOI: 10.3389/fimmu.2022.889296
• 发表时间: 2022
• 期刊: Frontiers in immunology
• 影响因子: 7.3

Neutrophil-induced ferroptosis promotes tumor necrosis in glioblastoma progression.

• DOI: 10.1038/s41467-020-19193-y
• 发表时间: 2020-10-27
• 期刊: Nature communications
• 影响因子: 16.6
• 作者: Yee PP;Wei Y;Kim SY;Lu T;Chih SY;Lawson C;Tang M;Liu Z;Anderson B;Thamburaj K;Young MM;Aregawi DG;Glantz MJ;Zacharia BE;Specht CS;Wang HG;Li W
• 通讯作者: Li W

Tumor necrosis: A synergistic consequence of metabolic stress and inflammation.

• DOI: 10.1002/bies.202100029
• 发表时间: 2021-07
• 期刊: BioEssays : news and reviews in molecular, cellular and developmental biology
• 作者: Yee PP;Li W
• 通讯作者: Li W