Contribute to the breeding expansion and to the genetic diversity at California NPRC

项目摘要 非人灵长类动物（NHP）人类疾病模型是生物医学研究的基础。底层 生理和代谢，以及非人类灵长类动物的解剖和基因组结构， 与其他哺乳动物模型相比，与人类相似。猕猴是最常用的非人类 生物医学研究中的灵长类动物。人类和恒河猴的相似之处使得这些动物 研究传染病发病机制的杰出模型，如疟疾、登革热和获得性 免疫缺陷综合征（艾滋病），各种传染性病原体的疫苗开发，以及人类 病理学此外，非人类灵长类动物需要作为生物防御研究的模型 特别是用于针对可能用于生物战的试剂的疫苗开发。 于二零二零年，持续的不可预见的COVID-19大流行为本已脆弱的NHP增添额外压力 通过增加世界各地的需求来增加供应。正因为如此，NPRC在NIH/ORIP的支持下， 启动了建立NHP战略储备（NSR）的倡议。在COVID-19大流行期间， 加勒比灵长类动物研究中心（CPRC）能够立即提供动物，以支持 COVID-19研究为科学做出了最大的贡献。产生的科学结果 CPRC的贡献可在科学，自然和实验医学杂志等顶级期刊上查阅 还有其他的此外，强调NIH/ORIP资助资源的价值，并作为 随着NSR的发展，CPRC一直愿意并积极参与与一些NPRC的协议 为了提供高质量的动物，以扩大其繁殖种群，并增加其遗传 多样性本行政补充旨在提供高品质的印度原产恒河猴，出生和 在CPRC进行繁殖，以扩大加州国家灵长类动物中心的繁殖能力和基因库 研究中心

Project Summary Nonhuman primates (NHP) models for human disease are essential for biomedical research. The underlying physiology and metabolism, as well as anatomical and genomic structures of nonhuman primates are more similar to humans than are other mammalian animal models. Macaques are the most commonly used nonhuman primates in biomedical research. The similarities between human and rhesus macaques make these animals outstanding models for the study of infectious disease pathogenesis such as in malaria, dengue and Acquired Immunodeficiency Syndrome (AIDS), of vaccine development for a variety of infectious agents, and of human pathologies. In addition, nonhuman primates are needed as models for biodefense research initiatives particularly for vaccine development against agents with potential use in bio-warfare. In 2020, the ongoing unforeseen COVID-19 pandemic added an additional stress to the already tenuous NHP supply by increasing the demand around the world. Because of that, the NPRCs, with the support of NIH/ORIP, launched an initiative to establish the NHP Strategic Reserve (NSR). At the time of the COVID-19 pandemic, the Caribbean Primate Research Center (CPRC) was in the position to supply animals, immediately, in support of COVID-19 research which has resulted in a topmost contribution to science. Scientific results generated with CPRC's contribution are available in top journals like Science, Nature, and Journal of Experimental Medicine among others. In addition, underscoring the value of this NIH/ORIP-funded resource, and as one early step in the development of the NSR, CPRC has been willing and proactively engaged in agreements with some NPRCs in order to supply high quality animals to expand their breeding population and to increase their genetic diversity. This Administrative Supplement seek to supply high quality Indian-origin rhesus macaques, born and breed at the CPRC, to expand the breeding capabilities and the genetic pool at California National Primate Research Center.