CARIBBEAN PRIMATE RESEARCH CENTER

 描述(由申请者提供)：本申请的主要目标是通过对运营、管理、兽医护理和研究的支持，改善和维护加勒比灵长类研究中心(CPRC)独特的研究资源。CPRC由四个综合设施组成：(1)Cayo Santiago，CPRC最有价值的研究资源，保存着1938年从印度带到Cayo Santiago(CS)的一群自由放养的恒河猴；(2)Sabana Seca野战站，CPRC的总部位于圣胡安外10英里处，那里存放着各种户外配置的来自Cayo Santiago殖民地的恒河猴，用于生物医学和行为研究，这些研究在自由放养的动物上是不可行的；(3)位于圣胡安医学校区(MSC)的病毒学和遗传学实验室(LVG)，该实验室支持以恒河猴为模型的多项研究活动；以及(4)灵长类动物形态实验室(LPM)，该实验室也位于MSC，收藏了CPRC的骨骼收藏，包括用于遗传、发育、病理和解剖学研究的非人类灵长类骨骼的独特组合。正如本提案所述，CPRC被组织为四个互补和综合的部门：灵长类资源、病毒学和遗传学、行为和神经科学以及灵长类形态学。在这项申请中，要求提供资金以维护中非合作伙伴委员会灵长类资源的基本基础设施，这些基础设施用于支持当地、国家和国际上的许多研究项目。这笔赠款还将使CPRC能够寻求额外的支持，以发展应用研究部分下的翻译科学倡议(TSI)。这一TSI的主要优势是进行多学科协作研究，为与不同人类疾病相关的临床前翻译项目建立和验证NHP模型。在NIH的持续支持下，CPRC仍将是一个重要的国家研究资源，并将能够为NIH赞助的研究项目提供具有明确遗传和病毒学背景的健康印度源恒河猴。

 DESCRIPTION (provided by applicant): The major goal of this application is to improve and maintain the Caribbean Primate Research Center's (CPRC) unique research resources through support of operations, administration, veterinary care and research. The CPRC consists of four integrated facilities: (1) Cayo Santiago, the most valuable of the CPRC research resources that holds a colony of free-ranging rhesus brought from India to Cayo Santiago (CS) in 1938.; (2) the Sabana Seca Field Station, the CPRC's head quarters located 10 miles outside of San Juan that houses rhesus monkeys derived from Cayo Santiago colony in various outdoor configurations for biomedical and behavioral studies that are not feasible on free-ranging animals; (3) the Laboratory of Virology and Genetics (LVG), located on the Medical Sciences Campus (MSC), in San Juan which support several research initiatives using rhesus monkeys as a model; and (4) the Laboratory of Primate Morphology (LPM), which is also located on the MSC, and houses the CPRC skeletal collections, unique assemblages of nonhuman primate skeletons for genetic, developmental, pathological and anatomical research. As described in this proposal, CPRC is organized into four complementary and integrated divisions: Primate Resources, Virology and Genetics, Behavior and Neurosciences, and Primate Morphology. Funds are requested in this application to maintain CPRC basic infrastructure of Primate Resources, which are used to support numerous research projects locally, national and internationally. This grant will also allow CPRC to seek additional support to develop the Translational Science Initiative (TSI) under the Applied Research Component. A major strength of this TSI is conducting multidisciplinary collaborative studies to establish and validate NHP models for preclinical translational projects related to different human diseases. With continued NIH support, the CPRC will remain a significant national research resource and will be able to provide healthy indian-origin rhesus monkeys of defined genetic and virological background to NIH-sponsored research programs.