CARIBBEAN PRIMATE RESEARCH CENTER

 描述（由申请人提供）：本申请的主要目标是通过支持运营，管理，兽医护理和研究来改善和维护加勒比灵长类动物研究中心（CPRC）的独特研究资源。CPRC由四个综合设施组成：（1）Cayo圣地亚哥，CPRC最有价值的研究资源，拥有1938年从印度带到Cayo圣地亚哥（CS）的自由放养的恒河猴群体。(2)Sabana Seca野外工作站，CPRC的总部位于圣胡安外10英里处，以各种户外配置安置来自Cayo圣地亚哥殖民地的恒河猴，用于生物医学和行为研究，这在自由放养的动物上是不可行的;（3）病毒学和遗传学实验室（LVG），位于医学科学校园（MSC），在圣胡安，它支持以恒河猴为模型的几项研究倡议;和（4）灵长类动物形态学实验室（LPM），也位于MSC上，并容纳CPRC骨骼收藏品，非人类灵长类动物骨骼的遗传，发育，病理学和解剖学研究。如本提案所述，CPRC分为四个互补和综合的部门：灵长类动物资源，病毒学和遗传学，行为和神经科学以及灵长类动物形态学。本申请要求提供资金，以维持CPRC灵长类动物资源的基本基础设施，这些资源用于支持当地、国家和国际的许多研究项目。这笔赠款还将使CPRC能够寻求额外的支持，以发展应用研究部分下的转化科学计划（TSI）。TSI的主要优势是进行多学科合作研究，以建立和验证与不同人类疾病相关的临床前转化项目的NHP模型。在NIH的持续支持下，CPRC仍将是一个重要的国家研究资源，并将能够为NIH赞助的研究项目提供具有明确遗传和病毒学背景的健康印度恒河猴。

 DESCRIPTION (provided by applicant): The major goal of this application is to improve and maintain the Caribbean Primate Research Center's (CPRC) unique research resources through support of operations, administration, veterinary care and research. The CPRC consists of four integrated facilities: (1) Cayo Santiago, the most valuable of the CPRC research resources that holds a colony of free-ranging rhesus brought from India to Cayo Santiago (CS) in 1938.; (2) the Sabana Seca Field Station, the CPRC's head quarters located 10 miles outside of San Juan that houses rhesus monkeys derived from Cayo Santiago colony in various outdoor configurations for biomedical and behavioral studies that are not feasible on free-ranging animals; (3) the Laboratory of Virology and Genetics (LVG), located on the Medical Sciences Campus (MSC), in San Juan which support several research initiatives using rhesus monkeys as a model; and (4) the Laboratory of Primate Morphology (LPM), which is also located on the MSC, and houses the CPRC skeletal collections, unique assemblages of nonhuman primate skeletons for genetic, developmental, pathological and anatomical research. As described in this proposal, CPRC is organized into four complementary and integrated divisions: Primate Resources, Virology and Genetics, Behavior and Neurosciences, and Primate Morphology. Funds are requested in this application to maintain CPRC basic infrastructure of Primate Resources, which are used to support numerous research projects locally, national and internationally. This grant will also allow CPRC to seek additional support to develop the Translational Science Initiative (TSI) under the Applied Research Component. A major strength of this TSI is conducting multidisciplinary collaborative studies to establish and validate NHP models for preclinical translational projects related to different human diseases. With continued NIH support, the CPRC will remain a significant national research resource and will be able to provide healthy indian-origin rhesus monkeys of defined genetic and virological background to NIH-sponsored research programs.