Administrative Core

行政核心

• 批准号: 10461121
• 负责人: Charles DeCarli
• 金额: $ 54.1万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-15 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10461121
• 关键词: Address; Adherence; Advisory Committees; Affect; Aging; Alzheimer' s Disease; Alzheimer' s disease risk; Animal Welfare; Annual Reports; Award; Behavioral Research; Biological Markers; Caregiver research; Caring; Clinical; Cognitive; Cognitive aging; Collaborations; Communities; Data; Data Set; Dementia; Development; Diagnosis; Disease; Early Diagnosis; Ensure; Environment; Epidemiology; Faculty; Funding; Funding Agency; Future; Geography; Goals; Grant; Growth; Heterogeneity; Image; Infrastructure; International; Leadership; Longevity; Mission; Outcome; Participant; Pathology; Policies; Population Heterogeneity; Process; Research; Research Personnel; Research Project Grants; Research Training; Resources; Risk; Risk Factors; Sampling; Science; Scientist; Serum; Strategic Planning; Time; Training; Training Programs; United States National Institutes of Health; Vision; Work; aging brain; caregiving; collaborative environment; community based research; complement resource; data exchange; ethnic minority; flexibility; high risk; human subject; improved; innovation; next generation; novel; outreach; prevent; programs; racial minority population; recruit; study population; success; therapy development; treatment strategy; undergraduate student

PROJECT SUMMARY/ABSTRACT - Administrative Core The mission of the UC Davis Alzheimer’s Disease Research Center (UCD ADRC) is to advance the science of healthy brain aging while caring for those affected by dementia. To accomplish this mission, we have created a highly integrated and collaborative environment with extensive resources to support studies on the heterogeneity of cognitive aging and progression to dementia among diverse populations. The Administrative Core (AC) supports this mission through overall direction and optimal utilization of center resources with emphasis on strategies that encompass 1) development of new research initiatives, 2) leveraging available resources through integration of research effort and pursuit of research funding, 3) program growth through local, national and international collaborations and initiation of new programs, and, finally, 4) pursuit of funding sources for training of junior scientists so as to expand and provide continuity for our program of research on aging and ADRD. Our approach addresses a number of milestones set by the National Alzheimer’s Project Act by 1) evaluating disparities among ethnic and racial minority populations that are at higher risk for AD to mitigate risk and improve cognitive outcomes, 2) fully characterizing mixed pathologies and identifying unique risk factors,3) accelerating the development of treatments that would prevent, halt, or reverse the course of Alzheimer’s disease (AD), 4) improving early diagnosis through discovery of novel imaging and serum biomarkers, 5) developing novel dementia treatment strategies, and 6) supporting caregiving through funded caregiver research. The AC also has a long tradition of supporting the overall NIA ADC Network to achieve NAPA goals “…through increasing flexibility and collaboration by leveraging resources, capabilities and research participants across the network”. Consistent with our overall approach, the AC also has historically contributed to efforts to “…unify goals, ensure that resources are most efficiently utilized, and is suitably flexible to facilitate the ability of the ADC network to respond to a dynamic scientific environment while incorporating the needs of all stakeholders…” As such, the AC provides outstanding leadership along with the infrastructure and the administrative support needed to meld the various Cores and geographically dispersed units of the UCD ADRC into a true, coherent and effective research center. Specifically, the AC will direct and strategically plan to utilize the full complement of resources and expertise of the UCD ADRC, incorporating the developmental projects, our community based research approach and extensive research training program to fulfill the milestones of NAPA.

项目摘要/摘要--行政核心 加州大学戴维斯分校阿尔茨海默病研究中心(UCD ADRC)的使命是推动 健康的大脑老化，同时照顾受痴呆症影响的人。为了完成这项任务，我们有 创建了一个高度集成和协作的环境，拥有广泛的资源来支持研究 不同人群认知老化与痴呆症进展的异质性。这个 行政核心(AC)通过全面指导和优化利用中心来支持这一使命 资源，重点放在战略上，包括1)开发新的研究举措，2) 通过整合研究工作和争取研究资金来利用现有资源，3) 通过地方、国家和国际合作以及启动新计划实现计划增长， 最后，4)寻求培训初级科学家的资金来源，以扩大和提供 我们关于衰老和ADRD的研究计划。我们的方法解决了由 国家阿尔茨海默氏症项目法案，通过1)评估以下族裔和种族少数群体之间的差异 AD在降低风险和改善认知结果方面的风险更高，2)充分表现出喜忧参半的特征 病理和识别独特的风险因素，3)加速开发治疗方法， 预防、阻止或逆转阿尔茨海默病(AD)的进程，4)通过以下方式提高早期诊断 发现新的影像和血清生物标志物，5)开发新的痴呆症治疗策略，6) 通过资助照顾者研究来支持照顾者。咨询委员会也有支持 整体NIA ADC网络实现国家适应行动方案目标“…通过以下方式提高灵活性和协作能力 利用整个网络的资源、能力和研究参与者“。与我们的总体情况一致 作为一种方法，AC也在历史上为“…”做出了贡献统一目标，确保资源最多 有效利用，并且适当灵活地促进ADC网络响应动态 科学的环境，同时纳入所有利益相关者的需求…“因此，空调提供了 出色的领导力以及基础设施和行政支持，将各种 UCD ADRC的核心和地理上分散的单元进行真实、连贯和有效的研究 中间。具体来说，咨询委员会将指导和策略性地计划充分利用资源和 UCD ADRC的专业知识，纳入了我们基于社区的研究的发展项目 为实现国家适应行动方案的里程碑而采取的方法和广泛的研究培训方案。