Administrative Core

行政核心

• 批准号: 10461121
• 负责人: Charles DeCarli
• 金额: $ 54.1万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-15 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10461121
• 关键词: Address; Adherence; Advisory Committees; Affect; Aging; Alzheimer' s Disease; Alzheimer' s disease risk; Animal Welfare; Annual Reports; Award; Behavioral Research; Biological Markers; Caregiver research; Caring; Clinical; Cognitive; Cognitive aging; Collaborations; Communities; Data; Data Set; Dementia; Development; Diagnosis; Disease; Early Diagnosis; Ensure; Environment; Epidemiology; Faculty; Funding; Funding Agency; Future; Geography; Goals; Grant; Growth; Heterogeneity; Image; Infrastructure; International; Leadership; Longevity; Mission; Outcome; Participant; Pathology; Policies; Population Heterogeneity; Process; Research; Research Personnel; Research Project Grants; Research Training; Resources; Risk; Risk Factors; Sampling; Science; Scientist; Serum; Strategic Planning; Time; Training; Training Programs; United States National Institutes of Health; Vision; Work; aging brain; caregiving; collaborative environment; community based research; complement resource; data exchange; ethnic minority; flexibility; high risk; human subject; improved; innovation; next generation; novel; outreach; prevent; programs; racial minority population; recruit; study population; success; therapy development; treatment strategy; undergraduate student

PROJECT SUMMARY/ABSTRACT - Administrative Core The mission of the UC Davis Alzheimer’s Disease Research Center (UCD ADRC) is to advance the science of healthy brain aging while caring for those affected by dementia. To accomplish this mission, we have created a highly integrated and collaborative environment with extensive resources to support studies on the heterogeneity of cognitive aging and progression to dementia among diverse populations. The Administrative Core (AC) supports this mission through overall direction and optimal utilization of center resources with emphasis on strategies that encompass 1) development of new research initiatives, 2) leveraging available resources through integration of research effort and pursuit of research funding, 3) program growth through local, national and international collaborations and initiation of new programs, and, finally, 4) pursuit of funding sources for training of junior scientists so as to expand and provide continuity for our program of research on aging and ADRD. Our approach addresses a number of milestones set by the National Alzheimer’s Project Act by 1) evaluating disparities among ethnic and racial minority populations that are at higher risk for AD to mitigate risk and improve cognitive outcomes, 2) fully characterizing mixed pathologies and identifying unique risk factors,3) accelerating the development of treatments that would prevent, halt, or reverse the course of Alzheimer’s disease (AD), 4) improving early diagnosis through discovery of novel imaging and serum biomarkers, 5) developing novel dementia treatment strategies, and 6) supporting caregiving through funded caregiver research. The AC also has a long tradition of supporting the overall NIA ADC Network to achieve NAPA goals “…through increasing flexibility and collaboration by leveraging resources, capabilities and research participants across the network”. Consistent with our overall approach, the AC also has historically contributed to efforts to “…unify goals, ensure that resources are most efficiently utilized, and is suitably flexible to facilitate the ability of the ADC network to respond to a dynamic scientific environment while incorporating the needs of all stakeholders…” As such, the AC provides outstanding leadership along with the infrastructure and the administrative support needed to meld the various Cores and geographically dispersed units of the UCD ADRC into a true, coherent and effective research center. Specifically, the AC will direct and strategically plan to utilize the full complement of resources and expertise of the UCD ADRC, incorporating the developmental projects, our community based research approach and extensive research training program to fulfill the milestones of NAPA.

项目摘要/摘要 - 行政核心 加州大学戴维斯分校阿尔茨海默病研究中心 (UCD ADRC) 的使命是推进阿尔茨海默氏症研究的科学发展 健康的大脑老化，同时照顾患有痴呆症的人。为了完成这个使命，我们有 创建了一个高度集成和协作的环境，拥有广泛的资源来支持研究 关于不同人群认知衰老和痴呆进展的异质性。这 行政核心 (AC) 通过总体指导和中心的优化利用来支持这一使命 资源重点关注战略，包括 1) 开发新的研究计划，2) 通过整合研究工作和寻求研究经费来利用可用资源，3) 通过地方、国家和国际合作以及新项目的启动来促进项目的发展，以及， 最后，4）寻求培训初级科学家的资金来源，以扩大和提供连续性 我们关于衰老和 ADRD 的研究计划。我们的方法解决了由 国家阿尔茨海默病项目法案通过 1) 评估少数族裔和种族人口之间的差异， 患有 AD 的风险较高，可以降低风险并改善认知结果，2) 充分表征混合 病理学并确定独特的风险因素，3）加速开发治疗方法 预防、阻止或逆转阿尔茨海默氏病 (AD) 的病程，4) 通过以下方式改善早期诊断 发现新的成像和血清生物标志物，5) 开发新的痴呆症治疗策略，以及 6) 通过资助护理人员研究来支持护理工作。审计委员会也有着支持 总体 NIA ADC 网络实现 NAPA 目标“……通过提高灵活性和协作 利用整个网络的资源、能力和研究参与者”。与我们的整体一致 方法，审计委员会历来也致力于“……统一目标，确保资源最有效” 有效利用，并且具有适当的灵活性，以促进 ADC 网络响应动态的能力 科学环境，同时纳入所有利益相关者的需求……”因此，AC 提供 出色的领导力以及融合各种所需的基础设施和行政支持 都柏林大学 ADRC 的核心和地理上分散的单位进行真实、连贯和有效的研究 中心。具体而言，审计委员会将指导和战略性地规划利用全部资源和 都柏林大学 ADRC 的专业知识，结合了发展项目、我们基于社区的研究 方法和广泛的研究培训计划，以实现国家适应行动方案的里程碑。