Administrative Core

行政核心

• 批准号: 10461121
• 负责人: Charles DeCarli
• 金额: $ 54.1万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-15 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10461121
• 关键词: Address; Adherence; Advisory Committees; Affect; Aging; Alzheimer' s Disease; Alzheimer' s disease risk; Animal Welfare; Annual Reports; Award; Behavioral Research; Biological Markers; Caregiver research; Caring; Clinical; Cognitive; Cognitive aging; Collaborations; Communities; Data; Data Set; Dementia; Development; Diagnosis; Disease; Early Diagnosis; Ensure; Environment; Epidemiology; Faculty; Funding; Funding Agency; Future; Geography; Goals; Grant; Growth; Heterogeneity; Image; Infrastructure; International; Leadership; Longevity; Mission; Outcome; Participant; Pathology; Policies; Population Heterogeneity; Process; Research; Research Personnel; Research Project Grants; Research Training; Resources; Risk; Risk Factors; Sampling; Science; Scientist; Serum; Strategic Planning; Time; Training; Training Programs; United States National Institutes of Health; Vision; Work; aging brain; caregiving; collaborative environment; community based research; complement resource; data exchange; ethnic minority; flexibility; high risk; human subject; improved; innovation; next generation; novel; outreach; prevent; programs; racial minority population; recruit; study population; success; therapy development; treatment strategy; undergraduate student

PROJECT SUMMARY/ABSTRACT - Administrative Core The mission of the UC Davis Alzheimer’s Disease Research Center (UCD ADRC) is to advance the science of healthy brain aging while caring for those affected by dementia. To accomplish this mission, we have created a highly integrated and collaborative environment with extensive resources to support studies on the heterogeneity of cognitive aging and progression to dementia among diverse populations. The Administrative Core (AC) supports this mission through overall direction and optimal utilization of center resources with emphasis on strategies that encompass 1) development of new research initiatives, 2) leveraging available resources through integration of research effort and pursuit of research funding, 3) program growth through local, national and international collaborations and initiation of new programs, and, finally, 4) pursuit of funding sources for training of junior scientists so as to expand and provide continuity for our program of research on aging and ADRD. Our approach addresses a number of milestones set by the National Alzheimer’s Project Act by 1) evaluating disparities among ethnic and racial minority populations that are at higher risk for AD to mitigate risk and improve cognitive outcomes, 2) fully characterizing mixed pathologies and identifying unique risk factors,3) accelerating the development of treatments that would prevent, halt, or reverse the course of Alzheimer’s disease (AD), 4) improving early diagnosis through discovery of novel imaging and serum biomarkers, 5) developing novel dementia treatment strategies, and 6) supporting caregiving through funded caregiver research. The AC also has a long tradition of supporting the overall NIA ADC Network to achieve NAPA goals “…through increasing flexibility and collaboration by leveraging resources, capabilities and research participants across the network”. Consistent with our overall approach, the AC also has historically contributed to efforts to “…unify goals, ensure that resources are most efficiently utilized, and is suitably flexible to facilitate the ability of the ADC network to respond to a dynamic scientific environment while incorporating the needs of all stakeholders…” As such, the AC provides outstanding leadership along with the infrastructure and the administrative support needed to meld the various Cores and geographically dispersed units of the UCD ADRC into a true, coherent and effective research center. Specifically, the AC will direct and strategically plan to utilize the full complement of resources and expertise of the UCD ADRC, incorporating the developmental projects, our community based research approach and extensive research training program to fulfill the milestones of NAPA.

项目概要/摘要-行政核心 加州大学戴维斯分校阿尔茨海默病研究中心（UCD ADRC）的使命是推进以下科学： 健康的大脑老化，同时照顾那些受痴呆症影响的人。为了完成这一使命， 创造了一个高度整合和协作的环境，拥有广泛的资源来支持研究 在不同人群中认知老化和痴呆症进展的异质性。的 行政核心（AC）通过全面指导和最佳利用中心来支持这一使命 资源，重点是战略，包括1）发展新的研究计划，2） 通过整合研究工作和寻求研究资金来利用现有资源，3） 通过地方、国家和国际合作以及新项目的启动，实现项目增长， 最后，4）寻求资金来源，培训年轻科学家，以扩大和提供连续性， 我们对衰老和ADRD的研究计划。我们的方法解决了一些里程碑设置的 国家阿尔茨海默病项目法案，1）评估少数民族和种族人口之间的差异， AD的风险较高，以减轻风险并改善认知结果，2）完全表征混合 病理学和识别独特的风险因素，3）加速治疗的发展， 预防、停止或逆转阿尔茨海默病（AD）的进程，4）通过以下途径改善早期诊断： 发现新的成像和血清生物标志物，5）开发新的痴呆治疗策略，以及6） 通过资助看护者研究支持康复。AC也有支持的悠久传统， 国家评估方案发展援助网络总体实现国家适应行动方案目标“.通过增加灵活性和合作， 利用整个网络的资源、能力和研究参与者”。与我们的整体 在这种方法中，AC在历史上也为“......统一目标，确保资源最大化”的努力做出了贡献。 有效地利用，并且是适当灵活的，以促进ADC网络响应于动态特性的能力。 科学环境，同时考虑到所有利益攸关方的需求.”因此，AC提供了 杰出的领导能力沿着基础设施和行政支持， 核心和地理上分散的UCD ADRC单元变成一个真正的，连贯的和有效的研究 中心具体而言，咨询委员会将指导和战略规划，充分利用补充资源， UCD ADRC的专业知识，结合发展项目，我们的社区研究 国家适应行动方案的里程碑。