UC Davis Alzheimer's Disease Research Center

加州大学戴维斯分校阿尔茨海默病研究中心

• 批准号: 10666428
• 负责人: Charles DeCarli
• 金额: $ 318.85万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-15 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10666428
• 关键词: Acceleration; Address; Affect; Aging; Alzheimer' s Disease; Alzheimer' s disease patient; Alzheimer' s disease risk; Area; Autopsy; Awareness; Biological Markers; Blood; Caregiver research; Caring; Characteristics; Charge; Clinical; Cognition; Cognitive; Communities; Data; Database Management Systems; Databases; Dementia; Development; Diagnosis; Disease; Disparity; Early Diagnosis; Educational Status; Elderly; Environment; Fostering; Funding; Future; Goals; Health Professional; Heterogeneity; Image; Impaired cognition; Individual; International; Intervention; Investigation; Measures; Mentors; Methods; Mission; Outcome; Participant; Pathologic; Pathology; Persons; Phenotype; Population; Population Heterogeneity; Prevention; Prevention strategy; Qualifying; Research; Research Activity; Research Design; Research Infrastructure; Research Methodology; Research Personnel; Research Support; Resources; Risk Factors; Risk Reduction; Scanning; Science; Secure; Services; Technology; Training and Education; Translational Research; Vascular Diseases; Vision; Walking; aging brain; brain health; career; caregiving; cohort; collaborative environment; dementia risk; design; disparity reduction; education research; effective therapy; epidemiology study; ethnic minority population; ethnoracial; high risk; imaging biomarker; improved; innovation; insight; interdisciplinary collaboration; interest; neuropathology; next generation; novel; prevent; racial minority population; recruit; risk mitigation; stem; therapy development; tool; training opportunity

PROJECT SUMMARY/ABSTRACT - Overall The mission of the UC Davis Alzheimer’s Disease Research Center (UCD ADRC) is to promote a highly innovative and enriched research environment focused on understanding the heterogeneity of brain aging among diverse populations that will ultimately lead to effective therapies to prevent or mitigate dementia. This approach stems from the premise that emphasizing diversity enhances discovery and contributes to translational science as well as reducing disparities in brain health and care. To accomplish this mission, the UCD ADRC has developed innovative methods and a unique study design to recruit and retain a highly demographically diverse clinical and autopsy cohort. All UCD ADRC participants are longitudinally followed and deeply phenotyped with extensive clinical, blood and imaging biomarker measures as well as developing state-of-the-art quantitative neuropathology. The UCD ADRC succeeds at these efforts through a robust research infrastructure, state-of-the-art database management and a highly collaborative environment consisting of seven well integrated resource cores and one research education component (REC) designed to facilitate new research efforts and interventions, dissemination of research findings, education and training as well as encouraging researcher development. Our approach addresses several milestones set by the National Alzheimer’s Project Act to effectively treat Alzheimer’s disease and associated disorders (ADRD) by 2025. These include, but are not limited to: 1) M1.L., evaluating disparities among ethnic and racial minority populations that are at higher risk for AD to mitigate risk and improve cognitive outcomes, 2) M2.H., fully characterizing mixed pathologies and identifying unique risk factors,3) M5-7., accelerating the development of treatments that would prevent, halt, or reverse the course of Alzheimer’s disease (AD), 4) M9., improving early diagnosis through discovery of novel imaging and blood biomarkers, 5) M8., developing novel dementia prevention strategies, and 6) M13.E.,supporting caregiving through funded caregiver research. The UCD ADRC also directly supports multiple epidemiological studies of diverse communities through use of research methods and personnel to gain further insights into dementia risk reduction, early diagnosis, and the impact of various neuropathologies on aging and dementia. Our efforts reflect the evolving needs of an increasingly older and more diverse US population, which is expected to rise to nearly 14 million by midcentury. Moreover, while AD continues to be the major pathological cause of dementia, more recent studies—including one from the UCD ADRC—find that dementia pathology is multifactorial and highly heterogeneous, due in part to the co-occurrence of AD and vascular disease, which varies by ethnoracial characteristics, is emphasized as part of dementia prediction and which can be modified by treatment even in later life. The UCD ADRC is uniquely qualified to support this research focus with a considerable impact on future ADRD diagnosis and treatment.

项目摘要/摘要-总体

项目成果

Cholesterol, Amyloid Beta, Fructose, and LPS Influence ROS and ATP Concentrations and the Phagocytic Capacity of HMC3 Human Microglia Cell Line.

• DOI: 10.3390/ijms241210396
• 发表时间: 2023-06-20
• 期刊: International journal of molecular sciences
• 影响因子: 5.6

Non-invasive quantification of 18F-florbetaben with total-body EXPLORER PET.

使用全身 EXPLORER PET 对 18F-florbetaben 进行无创定量。

• DOI: 10.21203/rs.3.rs-3764930/v1
• 发表时间: 2023
• 期刊: Research square
• 作者: Holy,EmilyN;Li,Elizabeth;Bhattarai,Anjan;Fletcher,Evan;Alfaro,EvelynR;Harvey,DanielleJ;Spencer,BenjaminA;Cherry,SimonR;DeCarli,CharlesS;Fan,AudreyP
• 通讯作者: Fan,AudreyP

Resources for Enhancing Alzheimer's Caregiver Health in Vietnam (REACH VN): study protocol for a cluster randomized controlled trial to test the efficacy of a family dementia caregiver intervention in Vietnam.

• DOI: 10.1186/s13063-022-06228-6
• 发表时间: 2022-05-09
• 期刊: Trials
• 影响因子: 2.5

Interaction between Alzheimer's Disease and Cerebral Small Vessel Disease: A Review Focused on Neuroimaging Markers.

• DOI: 10.3390/ijms231810490
• 发表时间: 2022-09-10
• 期刊: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
• 影响因子: 5.6
• 作者: Kim, Si Eun;Kim, Hee Jin;Jang, Hyemin;Weiner, Michael W.;DeCarli, Charles;Na, Duk L.;Seo, Sang Won
• 通讯作者: Seo, Sang Won

Cardiovascular health and cognitive outcomes: Findings from a biracial population-based study in the United States.

心血管健康和认知结果：美国一项基于混血人口的研究的结果。

• DOI: 10.1002/alz.13421
• 发表时间: 2023
• 期刊: Alzheimer's & dementia : the journal of the Alzheimer's Association
• 作者: Dhana,Anisa;DeCarli,CharlesS;Dhana,Klodian;Desai,Pankaja;Holland,ThomasM;Evans,DenisA;Rajan,KumarB
• 通讯作者: Rajan,KumarB