Neuroimaging Core

神经影像核心

• 批准号: 10461128
• 负责人: Charles DeCarli
• 金额: $ 20.69万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-15 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10461128
• 关键词: Aging; Alzheimer' s Disease; Amyloid; Archives; Autopsy; Back; Biological Markers; Biomedical Engineering; Brain; Brain Injuries; Brain imaging; Clinical; Cognition; Cognitive; Collaborations; Communities; Complement; Computer Systems; Computer software; Country; Data; Data Analyses; Databases; Dementia; Diagnostic; Dimensions; Disease; Education; Faculty; Framingham Heart Study; Funding; Goals; Grant; Human; Image; Institution; International; Intuition; Life; Link; Longevity; Longitudinal Studies; MRI Scans; Machine Learning; Magnetic Resonance Imaging; Measurement; Measures; Medical center; Methods; Mission; Nuclear Pore Complex; Play; Positioning Attribute; Positron-Emission Tomography; Postdoctoral Fellow; Privatization; Process; Quality Control; Research; Research Personnel; Research Project Grants; Research Support; Resources; Role; Scanning; Scientist; Secure; Services; Structure; Students; System; Techniques; Tracer; Training; Vascular Diseases; Work; aging brain; base; cognitive change; cohort; computerized data processing; data management; education research; experience; faculty mentor; image processing; imaging biomarker; improved; investigator training; kinetic model; method development; neuroimaging; neuropathology; normal aging; novel; outreach; recruit; research clinical testing; statistics; success; usability

PROJECT SUMMARY: Neuroimaging Core The Neuroimaging Core (NC) plays an integral role in the UC Davis (UCD) ADRC scientific mission by providing imaging-based structural and functional markers of aging and disease processes. These imaging biomarkers support the primary aim of the UCD ADRC to understand factors that influence cognitive trajectories from normal aging to dementia. Building on nearly 15 years of success, the NC will continue to provide services related to acquisition, storage, post-processing and dissemination of imaging data. In addition, the NC will collaborate with other departments at UC Davis as well as other institutions to develop novel state- of-the-art methods for measuring the lifespan course of brain injury leading to dementia. The Aims of the NC reflect the steady progression of its capabilities. The NC is now a mature component of the ADRC that enriches the other Cores and the AD research community. It currently provides raw images to the Clinical and Neuropathology Cores to support diagnostic activities. The NC also provides validated state-of- the-art measurements of brain structure and function to the Data Management and Statistics Core and other collaborating centers to support research projects. Finally, the NC works with the Research Education Component and the Outreach Recruitment and Education Core to train investigators in neuroimaging methods and disseminate information regarding imaging related research. The addition of Dr. Audrey Fan to the NC brings a new dimension of expertise in the use of MRI and PET imaging for new biomarkers of vascular disease, aging and cognitive change. In addition to imaging acquisition expertise, she provides a strong link to the Biomedical Engineering Department at UC Davis and to new facilities such as the total-body EXPLORER PET scanner. The novel imaging strategies and kinetic modeling approaches from Dr. Fan’s lab complement existing NC research capabilities. With over 20 grants, including SCAN, currently supporting image acquisitions and processing by the NC, we provide benefits national and international collaborations that are far beyond the level of Core funding. The overall goals of the NC to image brain injury leading to dementia aligns with the National Alzheimer’s Project Act (NAPA) mission to identify pre-symptomatic AD, establishing early imaging biomarkers through large public-private studies such as ADNI. The goals of NC are to continue to provide essential resources to the UCD ADRC and build new capabilities at the forefront of neuroimaging.

项目摘要：神经成像核心 神经成像核心(NC)在加州大学戴维斯分校(UCD)ADRC的科学任务中发挥着不可或缺的作用 提供基于成像的衰老和疾病过程的结构和功能标记。这些成像 生物标记物支持UCD ADRC了解影响认知的因素的主要目标 从正常衰老到痴呆症的轨迹。在近15年成功的基础上，全国委员会将继续 提供有关影像数据的获取、存储、后处理和传播服务。此外, 全国委员会将与加州大学戴维斯分校的其他部门以及其他机构合作，开发新的国家- 测量导致痴呆症的脑损伤寿命过程的最先进方法。 全国委员会的目标反映了其能力的稳步发展。NC现在是 ADRC丰富了其他核心和AD研究社区。它目前提供原始图像给 临床和神经病理学核心，以支持诊断活动。NC还提供经过验证的状态 数据管理和统计核心等对大脑结构和功能的最新测量 支持研究项目的协作中心。最后，NC与研究性教育相结合 构成部分和外联征聘和教育核心，对调查人员进行神经成像方法培训 并传播有关成像相关研究的信息。 范鸿龄博士的加入为核磁共振和正电子发射计算机断层扫描的应用带来了新的专业知识 对血管疾病、衰老和认知变化的新生物标志物进行成像。除了成像采集之外 专业知识，她提供了与加州大学戴维斯分校生物医学工程系和新的 设施，如全身探测仪PET扫描仪。新的成像策略和动力学建模 来自范博士实验室的方法补充了现有的NC研究能力。 包括SCAN在内的20多项赠款目前支持NC进行图像采集和处理，我们 提供远远超出核心资金水平的国家和国际合作所带来的好处。这个 NC对导致痴呆症的脑损伤进行成像的总体目标与国家阿尔茨海默氏症项目一致 ACT(NAPA)的使命是识别症状前AD，通过大量的 像ADNI这样的公私合作研究。NC的目标是继续为 UCD ADRC，并在神经成像的前沿建立新的能力。