Early and life course socioeconomic adversity and dementia risk in Hispanics/Latinos
西班牙裔/拉丁裔的早期和生命历程社会经济逆境和痴呆风险
基本信息
- 批准号:10445900
- 负责人:
- 金额:$ 144.18万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-08-15 至 2025-07-31
- 项目状态:未结题
- 来源:
- 关键词:AddressAdultAffectAgeAgingAlzheimer&aposs DiseaseAlzheimer&aposs disease related dementiaAlzheimer&aposs disease riskAmyloidBehavioralBiologicalBiological AgingBiological MarkersBlood VesselsBrainBrain InjuriesChildhoodClinicalCognitive agingDNA MethylationDataDevelopmentDisadvantagedDistressEconomic ConditionsElderlyEtiologyFailureFosteringGeneticGenomicsGoalsGrowthHealthHeightHippocampus (Brain)HispanicHispanic PopulationsImmigrantImpaired cognitionInfluentialsInvestigationKnowledgeLatino PopulationLearningLifeLife Cycle StagesLinkLongevityMagnetic Resonance ImagingMeasuresMediatingModelingNerve DegenerationNeurocognitiveParticipantPathway interactionsPlant RootsPlasmaPlayPopulationPovertyResearchResearch PriorityResourcesRisk FactorsRoleShapesSiteStudy of LatinosTestingTimeWhite Matter HyperintensityWorkapolipoprotein E-4cardiometabolismcognitive changecognitive functioncohortcritical perioddementia riskdisadvantaged populationearly life adversityethnic minorityexperiencegray matterhealth inequalitieshigh riskinsightlow and middle-income countriesmethylation biomarkermiddle ageneuroimagingnovelpsychosocialracial and ethnicresiliencesocial culturesocial determinantssocial health determinantssocioeconomic adversitysocioeconomic disadvantagesocioeconomic disparitysocioeconomicssymposiumtau Proteinsvascular injury
项目摘要
Although the clinical manifestations of Alzheimer’s disease and related dementias (ADRD) typically emerge in
late life, early life/childhood risk factors play a role in their etiology. Because childhood is a period of brain
plasticity and sensitivity to enduring environmental influences, early socio-economic adversities can affect
brain development and maturation, fostering adverse cognitive changes later in life. Persisting poverty over the
life course may exacerbate these effects. Furthermore, genomic research in ADRDs does not fully consider the
social determinants of health that are robust causes of racial and ethnic ADRDs disparities. This research gap
is particularly important for Hispanics, who experience widespread socio-economic adversities, and are at high
risk of ADRD despite modest effect of ApoE4 on ADRD risk. The Study of Latinos Investigation of
Neurocognitive Aging (SOL INCA) and its MRI neuroimaging study are ideally suited to elucidating health
effects of life course socio-economic conditions given the large and richly characterized cohort with repeated
neurocognitive, vascular, and socio-cultural assessments. We will leverage these unparalleled resources to
understand how early and sustained adverse socioeconomic conditions shape risk of ADRD and the biological
mechanisms that may explain these effects. We posit that early socio-economic adversity will be related to
lower gray matter and hippocampal volumes, as a result of poverty-related exposures during key periods of
brain development and maturation. Later, these early adversities can foster steeper aging-related trajectories
of cognitive decline. Persisting adversities over the life course may also result in greater white matter
hyperintensity (WMH), due to poor cardiometabolic control arising from social determinants common in
disadvantaged populations. Longitudinal DNA methylation (DNAm) markers will provide novel insights about
the biological mechanisms linking early and sustained socio-economic adversities and indicators of ADRD risk.
ADRD-related biomarkers (MRI, plasma Amyloid, Tau and Neurodegeneration [ATN] and DNAm) will inform
whether the pathways linking socio-economic adversity are related to neurodegeneration, vascular injury, and
accelerated aging. The study will directly address NIA research priorities related to understanding the
pathways by which socio-economic, socio-cultural and behavioral factors affect neurocognitive aging.
虽然阿尔茨海默病和相关痴呆(ADRD)的临床表现通常出现在
项目成果
期刊论文数量(0)
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Charles DeCarli其他文献
Charles DeCarli的其他文献
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{{ truncateString('Charles DeCarli', 18)}}的其他基金
Do Atmospheric Ultrafine Particles Lodge in the Brain and Cause Cognitive Decline Leading to Alzheimer's Disease Related Dementias?
大气超细颗粒是否会滞留在大脑中并导致认知能力下降,从而导致阿尔茨海默病相关的痴呆症?
- 批准号:
10591354 - 财政年份:2022
- 资助金额:
$ 144.18万 - 项目类别:
Study of Latinos-Investigation of Neurocognitive Aging-Alzheimer's disease
拉丁裔研究-神经认知衰老-阿尔茨海默病的调查
- 批准号:
10629449 - 财政年份:2022
- 资助金额:
$ 144.18万 - 项目类别:
Study of Latinos-Investigation of Neurocognitive Aging-Alzheimer's disease
拉丁裔研究-神经认知衰老-阿尔茨海默病的调查
- 批准号:
10370841 - 财政年份:2022
- 资助金额:
$ 144.18万 - 项目类别:
Early and life course socioeconomic adversity and dementia risk in Hispanic/Latinos
西班牙裔/拉丁裔的早期和生命历程社会经济逆境和痴呆风险
- 批准号:
10831329 - 财政年份:2022
- 资助金额:
$ 144.18万 - 项目类别:
UC Davis Alzheimer's Disease Research Center
加州大学戴维斯分校阿尔茨海默病研究中心
- 批准号:
10461120 - 财政年份:2021
- 资助金额:
$ 144.18万 - 项目类别:
UC Davis Alzheimer's Disease Research Center
加州大学戴维斯分校阿尔茨海默病研究中心
- 批准号:
10666428 - 财政年份:2021
- 资助金额:
$ 144.18万 - 项目类别:
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