Early and life course socioeconomic adversity and dementia risk in Hispanics/Latinos
西班牙裔/拉丁裔的早期和生命历程社会经济逆境和痴呆风险
基本信息
- 批准号:10445900
- 负责人:
- 金额:$ 144.18万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-08-15 至 2025-07-31
- 项目状态:未结题
- 来源:
- 关键词:AddressAdultAffectAgeAgingAlzheimer&aposs DiseaseAlzheimer&aposs disease related dementiaAlzheimer&aposs disease riskAmyloidBehavioralBiologicalBiological AgingBiological MarkersBlood VesselsBrainBrain InjuriesChildhoodClinicalCognitive agingDNA MethylationDataDevelopmentDisadvantagedDistressEconomic ConditionsElderlyEtiologyFailureFosteringGeneticGenomicsGoalsGrowthHealthHeightHippocampus (Brain)HispanicHispanic PopulationsImmigrantImpaired cognitionInfluentialsInvestigationKnowledgeLatino PopulationLearningLifeLife Cycle StagesLinkLongevityMagnetic Resonance ImagingMeasuresMediatingModelingNerve DegenerationNeurocognitiveParticipantPathway interactionsPlant RootsPlasmaPlayPopulationPovertyResearchResearch PriorityResourcesRisk FactorsRoleShapesSiteStudy of LatinosTestingTimeWhite Matter HyperintensityWorkapolipoprotein E-4cardiometabolismcognitive changecognitive functioncohortcritical perioddementia riskdisadvantaged populationearly life adversityethnic minorityexperiencegray matterhealth inequalitieshigh riskinsightlow and middle-income countriesmethylation biomarkermiddle ageneuroimagingnovelpsychosocialracial and ethnicresiliencesocial culturesocial determinantssocial health determinantssocioeconomic adversitysocioeconomic disadvantagesocioeconomic disparitysocioeconomicssymposiumtau Proteinsvascular injury
项目摘要
Although the clinical manifestations of Alzheimer’s disease and related dementias (ADRD) typically emerge in
late life, early life/childhood risk factors play a role in their etiology. Because childhood is a period of brain
plasticity and sensitivity to enduring environmental influences, early socio-economic adversities can affect
brain development and maturation, fostering adverse cognitive changes later in life. Persisting poverty over the
life course may exacerbate these effects. Furthermore, genomic research in ADRDs does not fully consider the
social determinants of health that are robust causes of racial and ethnic ADRDs disparities. This research gap
is particularly important for Hispanics, who experience widespread socio-economic adversities, and are at high
risk of ADRD despite modest effect of ApoE4 on ADRD risk. The Study of Latinos Investigation of
Neurocognitive Aging (SOL INCA) and its MRI neuroimaging study are ideally suited to elucidating health
effects of life course socio-economic conditions given the large and richly characterized cohort with repeated
neurocognitive, vascular, and socio-cultural assessments. We will leverage these unparalleled resources to
understand how early and sustained adverse socioeconomic conditions shape risk of ADRD and the biological
mechanisms that may explain these effects. We posit that early socio-economic adversity will be related to
lower gray matter and hippocampal volumes, as a result of poverty-related exposures during key periods of
brain development and maturation. Later, these early adversities can foster steeper aging-related trajectories
of cognitive decline. Persisting adversities over the life course may also result in greater white matter
hyperintensity (WMH), due to poor cardiometabolic control arising from social determinants common in
disadvantaged populations. Longitudinal DNA methylation (DNAm) markers will provide novel insights about
the biological mechanisms linking early and sustained socio-economic adversities and indicators of ADRD risk.
ADRD-related biomarkers (MRI, plasma Amyloid, Tau and Neurodegeneration [ATN] and DNAm) will inform
whether the pathways linking socio-economic adversity are related to neurodegeneration, vascular injury, and
accelerated aging. The study will directly address NIA research priorities related to understanding the
pathways by which socio-economic, socio-cultural and behavioral factors affect neurocognitive aging.
虽然阿尔茨海默病和相关痴呆症(ADRD)的临床表现通常出现在老年痴呆症患者中,
晚年、早年/儿童期的危险因素在其病因中起作用。因为童年是大脑发育的时期
可塑性和敏感性持久的环境影响,早期的社会经济逆境可以影响
大脑发育和成熟,在以后的生活中促进不利的认知变化。长期贫穷,
生命进程可能加剧这些影响。此外,ADRD的基因组研究没有充分考虑
健康的社会决定因素是种族和民族ADRD差异的重要原因。这一研究空白
对西班牙裔人来说尤其重要,他们经历了广泛的社会经济困境,
尽管ApoE 4对ADRD风险有适度的影响,但ADRD风险仍然存在。拉丁裔美国人调查研究
神经认知老化(SOL印加)及其MRI神经成像研究非常适合于阐明健康
生活过程中的社会经济条件的影响,考虑到大量的和丰富的特点的队列,
神经认知血管和社会文化评估。我们将利用这些无与伦比的资源,
了解早期和持续的不利社会经济条件如何影响ADRD的风险,
可以解释这些影响的机制。我们认为,早期的社会经济逆境将与以下因素有关:
较低的灰质和海马体积,由于贫困相关的暴露在关键时期,
大脑发育和成熟。后来,这些早期的逆境可以促进更陡峭的衰老相关轨迹
认知能力下降在生命过程中持续的逆境也可能导致更多的白色物质
高强度(WMH),由于常见的社会决定因素引起的心脏代谢控制不良,
弱势群体。纵向DNA甲基化(DNAm)标记将提供新的见解,
早期和持续的社会经济逆境与ADRD风险指标之间的生物学机制。
ADRD相关生物标志物(MRI、血浆淀粉样蛋白、Tau和神经变性[ATN]和DNAm)将告知
连接社会经济逆境的途径是否与神经退行性变、血管损伤和
加速老化这项研究将直接解决与了解有关的NIA研究优先事项,
社会经济、社会文化和行为因素影响神经认知老化的途径。
项目成果
期刊论文数量(0)
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Charles DeCarli其他文献
Charles DeCarli的其他文献
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{{ truncateString('Charles DeCarli', 18)}}的其他基金
Do Atmospheric Ultrafine Particles Lodge in the Brain and Cause Cognitive Decline Leading to Alzheimer's Disease Related Dementias?
大气超细颗粒是否会滞留在大脑中并导致认知能力下降,从而导致阿尔茨海默病相关的痴呆症?
- 批准号:
10591354 - 财政年份:2022
- 资助金额:
$ 144.18万 - 项目类别:
Study of Latinos-Investigation of Neurocognitive Aging-Alzheimer's disease
拉丁裔研究-神经认知衰老-阿尔茨海默病的调查
- 批准号:
10629449 - 财政年份:2022
- 资助金额:
$ 144.18万 - 项目类别:
Study of Latinos-Investigation of Neurocognitive Aging-Alzheimer's disease
拉丁裔研究-神经认知衰老-阿尔茨海默病的调查
- 批准号:
10370841 - 财政年份:2022
- 资助金额:
$ 144.18万 - 项目类别:
Early and life course socioeconomic adversity and dementia risk in Hispanic/Latinos
西班牙裔/拉丁裔的早期和生命历程社会经济逆境和痴呆风险
- 批准号:
10831329 - 财政年份:2022
- 资助金额:
$ 144.18万 - 项目类别:
UC Davis Alzheimer's Disease Research Center
加州大学戴维斯分校阿尔茨海默病研究中心
- 批准号:
10461120 - 财政年份:2021
- 资助金额:
$ 144.18万 - 项目类别:
UC Davis Alzheimer's Disease Research Center
加州大学戴维斯分校阿尔茨海默病研究中心
- 批准号:
10666428 - 财政年份:2021
- 资助金额:
$ 144.18万 - 项目类别:
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