Study of Latinos-Investigation of Neurocognitive Aging-Alzheimer's disease

拉丁裔研究-神经认知衰老-阿尔茨海默病的调查

• 批准号: 10629449
• 负责人: Charles DeCarli
• 金额: $ 576.35万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-05-15 至 2028-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10629449
• 关键词: Address; Adult; Affect; Age; Aging; Alzheimer' s Disease; Alzheimer' s disease pathology; Alzheimer' s disease related dementia; Alzheimer’s disease biomarker; Biological; Biological Aging; Biological Markers; Biology; Blood Vessels; Brain; California; Cardiovascular Diseases; Cardiovascular system; Censuses; Cerebrovascular Trauma; Chronic; Cognitive; Cognitive aging; Country; Data; Dementia; Diabetes Mellitus; Disparate; Disparity; Elderly; Epigenetic Process; Ethnic Origin; Exposure to; Face; Funding; Genes; Genetic; Genetic Risk; Genomics; Genotype; Goals; Heterogeneity; Hispanic Community Health Study/Study of Latinos; Impaired cognition; Investigation; Knowledge; Latino; Latino Population; Magnetic Resonance Imaging; Measures; Mendelian randomization; Methods; Morbidity - disease rate; National Heart, Lung, and Blood Institute; National Institute on Alcohol Abuse and Alcoholism; Nerve Degeneration; Neurocognitive; Pathology; Plasma; Population; Population Growth; Population Heterogeneity; Public Health; Research; Risk; Risk Factors; Structure; Study of Latinos; Subgroup; Texas; Therapeutic Intervention; Training; Vascular Diseases; Vascularization; Visit; aging brain; bilingualism; brain tissue; burden of illness; cardiovascular disorder risk; career; cohort; critical period; dementia risk; disease phenotype; ethnic difference; experience; health disparity; improved; middle age; neuroimaging marker; polygenic risk score; prevent; preventive intervention; racial population; social culture; sociocultural determinant; symposium; tau-1; vascular contributions

Abstract By 2060, the CDC projects that the Latino population will experience the largest increase in Alzheimer’s disease and related dementia (ADRD) cases of all US ethnic/racial groups. The main explanation for high Latino ADRD is attributed largely to early and excess cardiovascular disease (CVD) morbidity contributing to disparately high ADRD. CVD risk factors emerge early in midlife among Latinos, thereby increasing exposures to exquisitely sensitive and highly vascularized brain tissue. Yet, to-date there has not been any study of Latinos with sufficiently deep CVD phenotyping and genotyping to adequately address this significant public health question. This scientific knowledge gap is a significant impediment to the field and public health given rapid Latino population growth projections, particularly for older adults. The Study of Latinos-Investigation of Neurocognitive Aging-Alzheimer’s Disease (SOL-INCA-AD) will augment the ongoing large, representative and unique cohort with 10-years of advanced biomarkers of Alzheimer's disease to understand cognitive aging and impairment amongst diverse Latinos. Together with 10-years of cognitive measures, MRI, deep CVD phenotyping, genomics and rich sociocultural data, SOL-INCA-AD is a high priority study that will fill major scientific knowledge gaps that form barriers to progress for Latino ADRD research.

摘要 到2060年，疾病预防控制中心预测，拉丁裔人口将经历阿尔茨海默氏症的最大增长 所有美国种族/人种组的疾病和相关痴呆（ADRD）病例。高的主要解释 拉丁裔ADRD主要归因于早期和过度的心血管疾病（CVD）发病率， 到极高的ADRD。CVD风险因素在拉丁美洲人的中年早期出现， 暴露在高度敏感和血管化的脑组织中。然而，迄今为止， 对具有足够深的CVD表型和基因分型的拉丁美洲人进行的研究，以充分解决这一问题 重大公共卫生问题。这种科学知识差距是该领域的一个重大障碍， 考虑到拉丁美洲人口的快速增长预测，特别是老年人的公共卫生。研究 拉丁裔-神经认知老化-阿尔茨海默病（SOL-INCA-AD）的调查将增加 正在进行的具有10年阿尔茨海默病晚期生物标志物的大型、代表性和独特队列 疾病，以了解认知老化和障碍之间的不同拉丁美洲人。加上10年的 认知测量，MRI，深CVD表型，基因组学和丰富的社会文化数据，SOL-INCA-AD是一个 高度优先的研究，将填补主要的科学知识差距，形成障碍，为拉丁美洲人的进步 ADRD研究。