Study of Latinos-Investigation of Neurocognitive Aging-Alzheimer's disease
拉丁裔研究-神经认知衰老-阿尔茨海默病的调查
基本信息
- 批准号:10629449
- 负责人:
- 金额:$ 576.35万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-05-15 至 2028-01-31
- 项目状态:未结题
- 来源:
- 关键词:AddressAdultAffectAgeAgingAlzheimer&aposs DiseaseAlzheimer&aposs disease pathologyAlzheimer&aposs disease related dementiaAlzheimer’s disease biomarkerBiologicalBiological AgingBiological MarkersBiologyBlood VesselsBrainCaliforniaCardiovascular DiseasesCardiovascular systemCensusesCerebrovascular TraumaChronicCognitiveCognitive agingCountryDataDementiaDiabetes MellitusDisparateDisparityElderlyEpigenetic ProcessEthnic OriginExposure toFaceFundingGenesGeneticGenetic RiskGenomicsGenotypeGoalsHeterogeneityHispanic Community Health Study/Study of LatinosImpaired cognitionInvestigationKnowledgeLatinoLatino PopulationMagnetic Resonance ImagingMeasuresMendelian randomizationMethodsMorbidity - disease rateNational Heart, Lung, and Blood InstituteNational Institute on Alcohol Abuse and AlcoholismNerve DegenerationNeurocognitivePathologyPlasmaPopulationPopulation GrowthPopulation HeterogeneityPublic HealthResearchRiskRisk FactorsStructureStudy of LatinosSubgroupTexasTherapeutic InterventionTrainingVascular DiseasesVascularizationVisitaging brainbilingualismbrain tissueburden of illnesscardiovascular disorder riskcareercohortcritical perioddementia riskdisease phenotypeethnic differenceexperiencehealth disparityimprovedmiddle ageneuroimaging markerpolygenic risk scorepreventpreventive interventionracial populationsocial culturesociocultural determinantsymposiumtau-1vascular contributions
项目摘要
Abstract
By 2060, the CDC projects that the Latino population will experience the largest increase in Alzheimer’s
disease and related dementia (ADRD) cases of all US ethnic/racial groups. The main explanation for high
Latino ADRD is attributed largely to early and excess cardiovascular disease (CVD) morbidity contributing
to disparately high ADRD. CVD risk factors emerge early in midlife among Latinos, thereby increasing
exposures to exquisitely sensitive and highly vascularized brain tissue. Yet, to-date there has not been any
study of Latinos with sufficiently deep CVD phenotyping and genotyping to adequately address this
significant public health question. This scientific knowledge gap is a significant impediment to the field and
public health given rapid Latino population growth projections, particularly for older adults. The Study of
Latinos-Investigation of Neurocognitive Aging-Alzheimer’s Disease (SOL-INCA-AD) will augment the
ongoing large, representative and unique cohort with 10-years of advanced biomarkers of Alzheimer's
disease to understand cognitive aging and impairment amongst diverse Latinos. Together with 10-years of
cognitive measures, MRI, deep CVD phenotyping, genomics and rich sociocultural data, SOL-INCA-AD is a
high priority study that will fill major scientific knowledge gaps that form barriers to progress for Latino
ADRD research.
摘要
到2060年,疾病预防控制中心预测,拉丁裔人口将经历阿尔茨海默氏症的最大增长
所有美国种族/人种组的疾病和相关痴呆(ADRD)病例。高的主要解释
拉丁裔ADRD主要归因于早期和过度的心血管疾病(CVD)发病率,
到极高的ADRD。CVD风险因素在拉丁美洲人的中年早期出现,
暴露在高度敏感和血管化的脑组织中。然而,迄今为止,
对具有足够深的CVD表型和基因分型的拉丁美洲人进行的研究,以充分解决这一问题
重大公共卫生问题。这种科学知识差距是该领域的一个重大障碍,
考虑到拉丁美洲人口的快速增长预测,特别是老年人的公共卫生。研究
拉丁裔-神经认知老化-阿尔茨海默病(SOL-INCA-AD)的调查将增加
正在进行的具有10年阿尔茨海默病晚期生物标志物的大型、代表性和独特队列
疾病,以了解认知老化和障碍之间的不同拉丁美洲人。加上10年的
认知测量,MRI,深CVD表型,基因组学和丰富的社会文化数据,SOL-INCA-AD是一个
高度优先的研究,将填补主要的科学知识差距,形成障碍,为拉丁美洲人的进步
ADRD研究。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Charles DeCarli其他文献
Charles DeCarli的其他文献
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{{ truncateString('Charles DeCarli', 18)}}的其他基金
Do Atmospheric Ultrafine Particles Lodge in the Brain and Cause Cognitive Decline Leading to Alzheimer's Disease Related Dementias?
大气超细颗粒是否会滞留在大脑中并导致认知能力下降,从而导致阿尔茨海默病相关的痴呆症?
- 批准号:
10591354 - 财政年份:2022
- 资助金额:
$ 576.35万 - 项目类别:
Study of Latinos-Investigation of Neurocognitive Aging-Alzheimer's disease
拉丁裔研究-神经认知衰老-阿尔茨海默病的调查
- 批准号:
10370841 - 财政年份:2022
- 资助金额:
$ 576.35万 - 项目类别:
Early and life course socioeconomic adversity and dementia risk in Hispanics/Latinos
西班牙裔/拉丁裔的早期和生命历程社会经济逆境和痴呆风险
- 批准号:
10445900 - 财政年份:2022
- 资助金额:
$ 576.35万 - 项目类别:
Early and life course socioeconomic adversity and dementia risk in Hispanic/Latinos
西班牙裔/拉丁裔的早期和生命历程社会经济逆境和痴呆风险
- 批准号:
10831329 - 财政年份:2022
- 资助金额:
$ 576.35万 - 项目类别:
UC Davis Alzheimer's Disease Research Center
加州大学戴维斯分校阿尔茨海默病研究中心
- 批准号:
10461120 - 财政年份:2021
- 资助金额:
$ 576.35万 - 项目类别:
UC Davis Alzheimer's Disease Research Center
加州大学戴维斯分校阿尔茨海默病研究中心
- 批准号:
10666428 - 财政年份:2021
- 资助金额:
$ 576.35万 - 项目类别:
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