Early and life course socioeconomic adversity and dementia risk in Hispanic/Latinos

西班牙裔/拉丁裔的早期和生命历程社会经济逆境和痴呆风险

• 批准号: 10831329
• 负责人: Charles DeCarli
• 金额: $ 41.95万
• 依托单位: ALBERT EINSTEIN COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-15 至 2025-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10831329
• 关键词: Acceleration; Address; Administrative Supplement; Adult; Alzheimer' s disease related dementia; Alzheimer' s disease risk; Area; Behavior; COVID-19 vaccine; Cognitive aging; Communication; Communities; Discrimination; Distant; England; Enrollment; Ethics; Eugenics; Failure; Genetic; Genetic study; Genomics; Goals; Height; Hispanic; Human; Impaired cognition; Individual; Latino; Latino Population; Legal; Life; Life Cycle Stages; Link; Marmota; Measures; Methods; Minority Groups; Minority Health Research; Modeling; Observational Study; Observational epidemiology; Outcome; Parents; Policies; Population Heterogeneity; Poverty; Public Health Practice; Research; Research Personnel; Risk; Seminal; Social Environment; Social Responsibility; Societies; Stigmatization; Voice; Work; burden of illness; community engagement; dementia risk; design; dissemination strategy; early detection biomarkers; epidemiology study; experience; health assessment; health disparity; health equity; health inequalities; improved; innovation; member; multidisciplinary; parent grant; social disparities; social epidemiology; social health determinants; social influence; social stigma; socioeconomic adversity; socioeconomics; tool; trait; vaccine hesitancy

ABSTRACT The goals of this administrative supplement to Early and Life Course Adversities and Dementia Risk in Latinos (1RF1AG077639; contact PI: Isasi) are to (1) address Ethical, Legal, and Societal Implications (ELSI) of research examining social determinants of health and Alzheimer's Disease and Related Dementias (ADRD) risk, and (2) develop methods to assess health equity impact of the research. Social epidemiology has been at the forefront of the identification of health disparities and research to understand its root causes. However, this area of social epidemiology brings the risks of unintended individual, bystander and groups harms by contributing to perpetuating the stigma associated with poverty and experienced by minoritized populations, such as the Hispanic/Latino population. These unintended risks can emerge when: (1) findings regarding disproportionate ADRD risk are interpreted as failures of the individual rather than of society, (2) findings are misused or misinterpreted to exacerbate stigmatizing and discriminatory practices, (3) we fail to integrate community voices and recognize the social context, such as the experience of living with poverty. This administrative supplement aims to address this important research gap by implementing a model for the co- design of the study's dissemination strategies and for the interpretation of study results. In addition, this supplement brings a multidisciplinary perspective building on the ELSI framework. Furthermore, it also addresses the potential risk of stigma and discrimination based on identified cognitive decline, which may limit participation cognitive aging and ADRD research for minoritized populations. Another challenge of observational epidemiological research is that it may be perceived as distant from public health practice, without a direct action for improving health equity in ADRD or other outcomes. Furthermore, methods for assessing the health equity impact of observational studies are still lacking. This supplement will adapt a model for assessing the potential health equity impact of the parent study. In this supplement, we leverage our team ELSI expertise and the Bridging Research, Accurate Information and Dialogue (BRAID) approach, an innovative model for incorporating community member perspectives. BRAID will be used to bring community voices to address the potential for individual and group harms, including stigma, and to move from a deficits model to a community assets model that aligns epidemiological research with community needs, as we effectively communicate study findings to maximize impact on structural or policy changes.

抽象的 拉丁美洲人的早期和生活课程逆境和痴呆症风险的行政补充的目标 （1RF1AG077639;联系PI：ISASI）是（1）解决的道德，法律和社会影响（ELSI）（ELSI） 研究卫生和阿尔茨海默氏病和相关痴呆症（ADRD）的社会决定因素（ADRD）的研究 风险和（2）开发评估研究健康公平影响的方法。社会流行病学一直在 鉴定健康差异和研究以了解其根本原因的最前沿。但是，这个 社会流行病学领域带来了意外的个人，旁观者和团体的风险 有助于使与贫困相关的污名和少数人口经历的污名化， 例如西班牙裔/拉丁裔人口。这些意外风险可能会出现：（1）有关 不成比例的ADRD风险被解释为个人而不是社会的失败，（2）发现是 滥用或误解以加剧污名化和歧视性实践，（3）我们无法整合 社区的声音并认识到社会环境，例如生活在贫困中的经历。这 行政补充旨在通过实施共同的模型来解决这一重要研究差距 研究的传播策略的设计以及研究结果的解释。此外，这 补充为ELSI框架带来了多学科的观点。此外，它也是如此 根据确定的认知下降，解决了污名和歧视的潜在风险，这可能会限制 少数人群的参与认知衰老和ADRD研究。另一个挑战 观察性流行病学研究是，它可能被认为与公共卫生实践相距甚远， 没有直接采取行动来改善ADRD或其他结果的健康公平。此外，方法 仍缺乏评估观察性研究的健康公平影响。该补充将适应模型 用于评估父母研究的潜在健康公平影响。在这项补充中，我们利用我们的团队 ELSI专业知识以及桥接研究，准确的信息和对话（编织）方法， 纳入社区成员观点的创新模型。编织将用于带来社区 声音以解决个人和群体危害的潜力，包括污名，并从赤字中移动 模型与社区资产模型，该模型将流行病学研究与社区需求保持一致 有效地传达研究结果，以最大程度地影响对结构或政策变化的影响。