Early and life course socioeconomic adversity and dementia risk in Hispanic/Latinos

西班牙裔/拉丁裔的早期和生命历程社会经济逆境和痴呆风险

• 批准号: 10831329
• 负责人: Charles DeCarli
• 金额: $ 41.95万
• 依托单位: ALBERT EINSTEIN COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-15 至 2025-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10831329
• 关键词: Acceleration; Address; Administrative Supplement; Adult; Alzheimer' s disease related dementia; Alzheimer' s disease risk; Area; Behavior; COVID-19 vaccine; Cognitive aging; Communication; Communities; Discrimination; Distant; England; Enrollment; Ethics; Eugenics; Failure; Genetic; Genetic study; Genomics; Goals; Height; Hispanic; Human; Impaired cognition; Individual; Latino; Latino Population; Legal; Life; Life Cycle Stages; Link; Marmota; Measures; Methods; Minority Groups; Minority Health Research; Modeling; Observational Study; Observational epidemiology; Outcome; Parents; Policies; Population Heterogeneity; Poverty; Public Health Practice; Research; Research Personnel; Risk; Seminal; Social Environment; Social Responsibility; Societies; Stigmatization; Voice; Work; burden of illness; community engagement; dementia risk; design; dissemination strategy; early detection biomarkers; epidemiology study; experience; health assessment; health disparity; health equity; health inequalities; improved; innovation; member; multidisciplinary; parent grant; social disparities; social epidemiology; social health determinants; social influence; social stigma; socioeconomic adversity; socioeconomics; tool; trait; vaccine hesitancy

ABSTRACT The goals of this administrative supplement to Early and Life Course Adversities and Dementia Risk in Latinos (1RF1AG077639; contact PI: Isasi) are to (1) address Ethical, Legal, and Societal Implications (ELSI) of research examining social determinants of health and Alzheimer's Disease and Related Dementias (ADRD) risk, and (2) develop methods to assess health equity impact of the research. Social epidemiology has been at the forefront of the identification of health disparities and research to understand its root causes. However, this area of social epidemiology brings the risks of unintended individual, bystander and groups harms by contributing to perpetuating the stigma associated with poverty and experienced by minoritized populations, such as the Hispanic/Latino population. These unintended risks can emerge when: (1) findings regarding disproportionate ADRD risk are interpreted as failures of the individual rather than of society, (2) findings are misused or misinterpreted to exacerbate stigmatizing and discriminatory practices, (3) we fail to integrate community voices and recognize the social context, such as the experience of living with poverty. This administrative supplement aims to address this important research gap by implementing a model for the co- design of the study's dissemination strategies and for the interpretation of study results. In addition, this supplement brings a multidisciplinary perspective building on the ELSI framework. Furthermore, it also addresses the potential risk of stigma and discrimination based on identified cognitive decline, which may limit participation cognitive aging and ADRD research for minoritized populations. Another challenge of observational epidemiological research is that it may be perceived as distant from public health practice, without a direct action for improving health equity in ADRD or other outcomes. Furthermore, methods for assessing the health equity impact of observational studies are still lacking. This supplement will adapt a model for assessing the potential health equity impact of the parent study. In this supplement, we leverage our team ELSI expertise and the Bridging Research, Accurate Information and Dialogue (BRAID) approach, an innovative model for incorporating community member perspectives. BRAID will be used to bring community voices to address the potential for individual and group harms, including stigma, and to move from a deficits model to a community assets model that aligns epidemiological research with community needs, as we effectively communicate study findings to maximize impact on structural or policy changes.

摘要