Early and life course socioeconomic adversity and dementia risk in Hispanic/Latinos

西班牙裔/拉丁裔的早期和生命历程社会经济逆境和痴呆风险

• 批准号: 10831329
• 负责人: Charles DeCarli
• 金额: $ 41.95万
• 依托单位: ALBERT EINSTEIN COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-15 至 2025-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10831329
• 关键词: Acceleration; Address; Administrative Supplement; Adult; Alzheimer' s disease related dementia; Alzheimer' s disease risk; Area; Behavior; COVID-19 vaccine; Cognitive aging; Communication; Communities; Discrimination; Distant; England; Enrollment; Ethics; Eugenics; Failure; Genetic; Genetic study; Genomics; Goals; Height; Hispanic; Human; Impaired cognition; Individual; Latino; Latino Population; Legal; Life; Life Cycle Stages; Link; Marmota; Measures; Methods; Minority Groups; Minority Health Research; Modeling; Observational Study; Observational epidemiology; Outcome; Parents; Policies; Population Heterogeneity; Poverty; Public Health Practice; Research; Research Personnel; Risk; Seminal; Social Environment; Social Responsibility; Societies; Stigmatization; Voice; Work; burden of illness; community engagement; dementia risk; design; dissemination strategy; early detection biomarkers; epidemiology study; experience; health assessment; health disparity; health equity; health inequalities; improved; innovation; member; multidisciplinary; parent grant; social disparities; social epidemiology; social health determinants; social influence; social stigma; socioeconomic adversity; socioeconomics; tool; trait; vaccine hesitancy

ABSTRACT The goals of this administrative supplement to Early and Life Course Adversities and Dementia Risk in Latinos (1RF1AG077639; contact PI: Isasi) are to (1) address Ethical, Legal, and Societal Implications (ELSI) of research examining social determinants of health and Alzheimer's Disease and Related Dementias (ADRD) risk, and (2) develop methods to assess health equity impact of the research. Social epidemiology has been at the forefront of the identification of health disparities and research to understand its root causes. However, this area of social epidemiology brings the risks of unintended individual, bystander and groups harms by contributing to perpetuating the stigma associated with poverty and experienced by minoritized populations, such as the Hispanic/Latino population. These unintended risks can emerge when: (1) findings regarding disproportionate ADRD risk are interpreted as failures of the individual rather than of society, (2) findings are misused or misinterpreted to exacerbate stigmatizing and discriminatory practices, (3) we fail to integrate community voices and recognize the social context, such as the experience of living with poverty. This administrative supplement aims to address this important research gap by implementing a model for the co- design of the study's dissemination strategies and for the interpretation of study results. In addition, this supplement brings a multidisciplinary perspective building on the ELSI framework. Furthermore, it also addresses the potential risk of stigma and discrimination based on identified cognitive decline, which may limit participation cognitive aging and ADRD research for minoritized populations. Another challenge of observational epidemiological research is that it may be perceived as distant from public health practice, without a direct action for improving health equity in ADRD or other outcomes. Furthermore, methods for assessing the health equity impact of observational studies are still lacking. This supplement will adapt a model for assessing the potential health equity impact of the parent study. In this supplement, we leverage our team ELSI expertise and the Bridging Research, Accurate Information and Dialogue (BRAID) approach, an innovative model for incorporating community member perspectives. BRAID will be used to bring community voices to address the potential for individual and group harms, including stigma, and to move from a deficits model to a community assets model that aligns epidemiological research with community needs, as we effectively communicate study findings to maximize impact on structural or policy changes.

摘要 拉丁裔早期和生活病程不良与痴呆症风险的这一行政补充的目标 (1RF1AG077639；联系PI：Isasi)旨在(1)解决以下问题的伦理、法律和社会影响(ELSI) 研究健康和阿尔茨海默病及相关痴呆的社会决定因素(ADRD) 风险，以及(2)开发方法来评估研究对健康公平的影响。社会流行病学一直处于 最前沿的是确定健康差距并研究了解其根本原因。不过，这个 社会流行病学领域带来了意外的个人、旁观者和群体受到伤害的风险 有助于延续与贫困有关的耻辱，并使少数群体经历的耻辱持久存在， 例如西班牙裔/拉丁裔人口。这些意外风险可能在以下情况下出现：(1)关于以下方面的调查结果 不成比例的ADRD风险被解释为个人的失败，而不是社会的失败，(2)研究结果是 误用或曲解以加剧污名化和歧视性做法；(3)我们未能整合 社区发出声音，并认识到社会背景，如与贫困生活的经历。这 行政副刊旨在通过实施联合研究的模式来解决这一重要的研究差距 设计研究的传播策略并解释研究结果。此外，这一点 附录提供了建立在ELSI框架上的多学科视角。此外，它还 解决基于已发现的认知衰退的耻辱和歧视的潜在风险，这可能会限制 小数化人群的参与、认知老化和ADRD研究。另一个挑战是 观察性流行病学研究可能被认为与公共卫生实践相去甚远， 没有采取直接行动来改善ADRD或其他成果中的卫生公平。此外，还提供了一种 评估观察性研究对健康公平的影响仍然缺乏。本增刊将改编一种模式 用于评估父母研究的潜在健康公平影响。在本增刊中，我们利用我们的团队 ELSI的专业知识和桥梁研究、准确的信息和对话(Braid)方法，以及 融入社区成员观点的创新模式。辫子将被用来带来社区 解决个人和群体伤害的可能性，包括耻辱，并从赤字中走出来的声音 将流行病学研究与社区需求相结合的社区资产模型，因为我们 有效地传达研究结果，以最大限度地影响结构或政策变化。