Early and life course socioeconomic adversity and dementia risk in Hispanic/Latinos

西班牙裔/拉丁裔的早期和生命历程社会经济逆境和痴呆风险

• 批准号: 10831329
• 负责人: Charles DeCarli
• 金额: $ 41.95万
• 依托单位: ALBERT EINSTEIN COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-15 至 2025-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10831329
• 关键词: Acceleration; Address; Administrative Supplement; Adult; Alzheimer' s disease related dementia; Alzheimer' s disease risk; Area; Behavior; COVID-19 vaccine; Cognitive aging; Communication; Communities; Discrimination; Distant; England; Enrollment; Ethics; Eugenics; Failure; Genetic; Genetic study; Genomics; Goals; Height; Hispanic; Human; Impaired cognition; Individual; Latino; Latino Population; Legal; Life; Life Cycle Stages; Link; Marmota; Measures; Methods; Minority Groups; Minority Health Research; Modeling; Observational Study; Observational epidemiology; Outcome; Parents; Policies; Population Heterogeneity; Poverty; Public Health Practice; Research; Research Personnel; Risk; Seminal; Social Environment; Social Responsibility; Societies; Stigmatization; Voice; Work; burden of illness; community engagement; dementia risk; design; dissemination strategy; early detection biomarkers; epidemiology study; experience; health assessment; health disparity; health equity; health inequalities; improved; innovation; member; multidisciplinary; parent grant; social disparities; social epidemiology; social health determinants; social influence; social stigma; socioeconomic adversity; socioeconomics; tool; trait; vaccine hesitancy

ABSTRACT The goals of this administrative supplement to Early and Life Course Adversities and Dementia Risk in Latinos (1RF1AG077639; contact PI: Isasi) are to (1) address Ethical, Legal, and Societal Implications (ELSI) of research examining social determinants of health and Alzheimer's Disease and Related Dementias (ADRD) risk, and (2) develop methods to assess health equity impact of the research. Social epidemiology has been at the forefront of the identification of health disparities and research to understand its root causes. However, this area of social epidemiology brings the risks of unintended individual, bystander and groups harms by contributing to perpetuating the stigma associated with poverty and experienced by minoritized populations, such as the Hispanic/Latino population. These unintended risks can emerge when: (1) findings regarding disproportionate ADRD risk are interpreted as failures of the individual rather than of society, (2) findings are misused or misinterpreted to exacerbate stigmatizing and discriminatory practices, (3) we fail to integrate community voices and recognize the social context, such as the experience of living with poverty. This administrative supplement aims to address this important research gap by implementing a model for the co- design of the study's dissemination strategies and for the interpretation of study results. In addition, this supplement brings a multidisciplinary perspective building on the ELSI framework. Furthermore, it also addresses the potential risk of stigma and discrimination based on identified cognitive decline, which may limit participation cognitive aging and ADRD research for minoritized populations. Another challenge of observational epidemiological research is that it may be perceived as distant from public health practice, without a direct action for improving health equity in ADRD or other outcomes. Furthermore, methods for assessing the health equity impact of observational studies are still lacking. This supplement will adapt a model for assessing the potential health equity impact of the parent study. In this supplement, we leverage our team ELSI expertise and the Bridging Research, Accurate Information and Dialogue (BRAID) approach, an innovative model for incorporating community member perspectives. BRAID will be used to bring community voices to address the potential for individual and group harms, including stigma, and to move from a deficits model to a community assets model that aligns epidemiological research with community needs, as we effectively communicate study findings to maximize impact on structural or policy changes.

抽象的 本行政补充的目标是针对拉丁美洲人的早期和生命历程中的逆境和痴呆风险 （1RF1AG077639；联系 PI：Isasi）将 (1) 解决道德、法律和社会影响 (ELSI) 研究检查健康和阿尔茨海默氏病及相关痴呆症 (ADRD) 的社会决定因素 风险，(2) 制定方法来评估研究的健康公平影响。社会流行病学已处于 识别健康差异并研究其根本原因的前沿。然而，这 社会流行病学领域带来了个人、旁观者和群体意外伤害的风险 导致少数民族人口所经历的与贫穷相关的耻辱永久化， 例如西班牙裔/拉丁裔人口。这些意外风险可能在以下情况下出现：(1) 关于 不成比例的 ADRD 风险被解释为个人而非社会的失败，(2) 研究结果是 被误用或误解以加剧污名化和歧视性做法，(3) 我们未能整合 社区的声音并认识到社会背景，例如贫困生活的经历。这 行政补充旨在通过实施合作模型来解决这一重要的研究空白 设计研究的传播策略和解释研究结果。此外，这 补充品带来了建立在 ELSI 框架之上的多学科视角。此外，它还 解决基于已确定的认知能力下降的耻辱和歧视的潜在风险，这可能会限制 参与少数民族人群的认知老化和 ADRD 研究。的另一个挑战 观察性流行病学研究可能被认为与公共卫生实践相距甚远， 没有采取直接行动来改善 ADRD 或其他结果中的健康公平性。此外，方法 仍然缺乏评估观察性研究对健康公平的影响。本补充将调整模型 用于评估母研究对健康公平的潜在影响。在本补充中，我们利用我们的团队 ELSI 专业知识和桥接研究、准确信息和对话 (BRAID) 方法 纳入社区成员观点的创新模式。 BRAID将用于带来社区 解决个人和群体潜在伤害（包括耻辱）并摆脱赤字的声音 模型到社区资产模型，使流行病学研究与社区需求保持一致，因为我们 有效地传达研究结果，以最大限度地提高对结构或政策变化的影响。