Neuroimaging Core

神经影像核心

• 批准号: 10666453
• 负责人: Charles DeCarli
• 金额: $ 20.75万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-15 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10666453
• 关键词: Aging; Alzheimer' s Disease; Amyloid; Archives; Autopsy; Back; Biological Markers; Biomedical Engineering; Brain; Brain Injuries; Brain imaging; Clinical; Cognition; Cognitive; Collaborations; Communities; Complement; Computer Systems; Computer software; Country; Data; Data Analyses; Databases; Dementia; Diagnostic; Dimensions; Disease; Education; Faculty; Framingham Heart Study; Funding; Goals; Grant; Human; Image; Institution; International; Intuition; Life; Link; Longevity; Longitudinal Studies; MRI Scans; Machine Learning; Magnetic Resonance Imaging; Measurement; Measures; Medical center; Methods; Mission; Nuclear Pore Complex; Play; Positioning Attribute; Positron-Emission Tomography; Postdoctoral Fellow; Privatization; Process; Quality Control; Research; Research Personnel; Research Project Grants; Research Support; Resources; Role; Scanning; Scientist; Secure; Services; Structure; Students; System; Techniques; Tracer; Training; Vascular Diseases; Work; aging brain; cognitive change; cohort; computerized data processing; data management; education research; experience; faculty mentor; image processing; imaging biomarker; improved; investigator training; kinetic model; method development; neuroimaging; neuropathology; normal aging; novel; outreach; recruit; research clinical testing; statistics; success; usability

PROJECT SUMMARY: Neuroimaging Core The Neuroimaging Core (NC) plays an integral role in the UC Davis (UCD) ADRC scientific mission by providing imaging-based structural and functional markers of aging and disease processes. These imaging biomarkers support the primary aim of the UCD ADRC to understand factors that influence cognitive trajectories from normal aging to dementia. Building on nearly 15 years of success, the NC will continue to provide services related to acquisition, storage, post-processing and dissemination of imaging data. In addition, the NC will collaborate with other departments at UC Davis as well as other institutions to develop novel state- of-the-art methods for measuring the lifespan course of brain injury leading to dementia. The Aims of the NC reflect the steady progression of its capabilities. The NC is now a mature component of the ADRC that enriches the other Cores and the AD research community. It currently provides raw images to the Clinical and Neuropathology Cores to support diagnostic activities. The NC also provides validated state-of- the-art measurements of brain structure and function to the Data Management and Statistics Core and other collaborating centers to support research projects. Finally, the NC works with the Research Education Component and the Outreach Recruitment and Education Core to train investigators in neuroimaging methods and disseminate information regarding imaging related research. The addition of Dr. Audrey Fan to the NC brings a new dimension of expertise in the use of MRI and PET imaging for new biomarkers of vascular disease, aging and cognitive change. In addition to imaging acquisition expertise, she provides a strong link to the Biomedical Engineering Department at UC Davis and to new facilities such as the total-body EXPLORER PET scanner. The novel imaging strategies and kinetic modeling approaches from Dr. Fan’s lab complement existing NC research capabilities. With over 20 grants, including SCAN, currently supporting image acquisitions and processing by the NC, we provide benefits national and international collaborations that are far beyond the level of Core funding. The overall goals of the NC to image brain injury leading to dementia aligns with the National Alzheimer’s Project Act (NAPA) mission to identify pre-symptomatic AD, establishing early imaging biomarkers through large public-private studies such as ADNI. The goals of NC are to continue to provide essential resources to the UCD ADRC and build new capabilities at the forefront of neuroimaging.

项目摘要：神经影像核心 神经影像核心 (NC) 在加州大学戴维斯分校 (UCD) ADRC 科学任务中发挥着不可或缺的作用 提供基于成像的衰老和疾病过程的结构和功能标记。这些成像 生物标志物支持 UCD ADRC 的主要目标，即了解影响认知的因素 从正常衰老到痴呆的轨迹。在近 15 年的成功基础上，NC 将继续 提供与成像数据的采集、存储、后处理和传播相关的服务。此外， NC 将与加州大学戴维斯分校的其他部门以及其他机构合作开发新颖的国家- 用于测量导致痴呆的脑损伤的寿命过程的最先进方法。 NC 的目标反映了其能力的稳步发展。 NC现已成为成熟的组件 ADRC 丰富了其他核心和 AD 研究社区。它目前向 支持诊断活动的临床和神经病理学核心。 NC 还提供经过验证的状态 对数据管理和统计核心等的大脑结构和功能进行最先进的测量 支持研究项目的合作中心。最后，NC 与研究教育合作 用于培训研究人员神经影像方法的组件和外展招募和教育核心 并传播有关成像相关研究的信息。 Audrey Fan 博士加入 NC 后，将 MRI 和 PET 的专业知识应用推向新的高度 血管疾病、衰老和认知变化的新生物标志物的成像。除了图像采集之外 专业知识，她为加州大学戴维斯分校的生物医学工程系和新的 全身 EXPLORER PET 扫描仪等设施。新颖的成像策略和动力学建模 范博士实验室的方法补充了现有的数控研究能力。 凭借包括 SCAN 在内的 20 多项资助，目前支持 NC 的图像采集和处理，我们 提供远远超出核心资金水平的国内和国际合作效益。这 NC 对导致痴呆的脑损伤进行成像的总体目标与国家阿尔茨海默病项目一致 法案 (NAPA) 的任务是识别症状前的 AD，通过大量数据建立早期影像生物标志物 公私合作研究，例如 ADNI。 NC 的目标是继续为 UCD ADRC 并在神经影像学前沿建立新能力。