Study of Latinos-Investigation of Neurocognitive Aging-Alzheimer's disease

拉丁裔研究-神经认知衰老-阿尔茨海默病的调查

• 批准号: 10370841
• 负责人: Charles DeCarli
• 金额: $ 667.95万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-05-15 至 2027-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10370841
• 关键词: Address; Adult; Affect; Age; Aging; Alzheimer' s Disease; Alzheimer' s disease pathology; Alzheimer' s disease related dementia; Alzheimer’s disease biomarker; Biological; Biological Aging; Biological Markers; Biology; Blood Vessels; Brain; California; Cardiovascular Diseases; Cardiovascular system; Censuses; Centers for Disease Control and Prevention (U.S.); Cerebrovascular Trauma; Chronic; Cognitive; Cognitive aging; Country; Data; Dementia; Diabetes Mellitus; Elderly; Epigenetic Process; Exposure to; Face; Funding; Genes; Genetic; Genetic Risk; Genomics; Genotype; Goals; Heterogeneity; Hispanic Community Health Study/Study of Latinos; Impaired cognition; Investigation; Knowledge; Latino; Latino Population; Magnetic Resonance Imaging; Measures; Mendelian randomization; Methods; Morbidity - disease rate; National Heart, Lung, and Blood Institute; Nerve Degeneration; Neurocognitive; Pathology; Plasma; Population; Population Growth; Population Heterogeneity; Public Health; Race; Research; Risk; Risk Factors; Structure; Study of Latinos; Subgroup; Texas; Therapeutic Intervention; Time; Training; Vascular Diseases; Visit; aging brain; bilingualism; brain tissue; burden of illness; cardiovascular disorder risk; career; cohort; critical period; dementia risk; disease phenotype; ethnic difference; experience; health disparity; improved; middle age; neuroimaging marker; polygenic risk score; prevent; preventive intervention; racial and ethnic; social culture; symposium; tau-1; vascular contributions

Abstract By 2060, the CDC projects that the Latino population will experience the largest increase in Alzheimer’s disease and related dementia (ADRD) cases of all US ethnic/racial groups. The main explanation for high Latino ADRD is attributed largely to early and excess cardiovascular disease (CVD) morbidity contributing to disparately high ADRD. CVD risk factors emerge early in midlife among Latinos, thereby increasing exposures to exquisitely sensitive and highly vascularized brain tissue. Yet, to-date there has not been any study of Latinos with sufficiently deep CVD phenotyping and genotyping to adequately address this significant public health question. This scientific knowledge gap is a significant impediment to the field and public health given rapid Latino population growth projections, particularly for older adults. The Study of Latinos-Investigation of Neurocognitive Aging-Alzheimer’s Disease (SOL-INCA-AD) will augment the ongoing large, representative and unique cohort with 10-years of advanced biomarkers of Alzheimer's disease to understand cognitive aging and impairment amongst diverse Latinos. Together with 10-years of cognitive measures, MRI, deep CVD phenotyping, genomics and rich sociocultural data, SOL-INCA-AD is a high priority study that will fill major scientific knowledge gaps that form barriers to progress for Latino ADRD research.

摘要 美国疾病控制与预防中心预计，到2060年，拉美裔人口将经历阿尔茨海默氏症的最大增长 美国所有族裔/种族的疾病和相关痴呆症(ADRD)病例。HIGH的主要解释 拉丁裔ADRD在很大程度上归因于早期和过度的心血管疾病(CVD)发病率 到不同程度的高ADRD。心血管疾病风险因素在拉美裔人中年早期出现，因此增加了 暴露在高度敏感和高度血管化的脑组织中。然而，到目前为止，还没有 对具有足够深的CVD表型和基因分型以充分解决这一问题的拉丁裔人的研究 重大的公共卫生问题。这一科学知识差距是该领域的重大障碍， 考虑到拉丁裔人口的快速增长预测，特别是老年人的人口增长，公共卫生。的研究。 拉丁裔-神经认知老化的调查-阿尔茨海默病(Sol-Inca-AD)将增加 具有10年阿尔茨海默病先进生物标志物的持续大规模、代表性和独一无二的队列研究 疾病，以了解不同拉美裔人的认知老化和损害。再加上十年的 认知测量、核磁共振、深层CVD表型、基因组学和丰富的社会文化数据，Sol-Inca-AD是一种 高度优先的研究，将填补构成拉丁裔进步障碍的重大科学知识空白 ADRD研究。