Progress in Vaccine Development for Infectious Diseases

传染病疫苗研发进展

• 批准号: 10467880
• 负责人: Thale Cross Jarvis
• 金额: $ 0.55万
• 依托单位: KEYSTONE SYMPOSIA
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-05-27 至 2023-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10467880
• 关键词: Academia; Address; Adjuvant; Advocate; Age; Animal Model; Antigens; Area; Biological Markers; Biology; Biomedical Engineering; Collaborations; Colorado; Communicable Diseases; Communities; Coupled; DNA; Development; Educational workshop; Empirical Research; Fostering; Future; Immune response; Immunization; Immunologist; Immunology; Industry; Knowledge; Learning; Life; Mentors; Messenger RNA; Methodology; Modern Medicine; Outcome; Participant; Proteins; Research; Research Personnel; Savings; Scheme; Science; Scientist; Speed; Structural Biologist; Structure; System; Technology; Vaccine Production; Vaccines; Viral Vector; Work; base; career; clinical implementation; clinical practice; combat; design; human pathogen; immunogenicity; nanomaterials; nanoparticle; novel; pandemic preparedness; pathogen; posters; programs; screening; structural biology; symposium; vaccine development; vaccine distribution; vaccine platform; vaccine response; vaccinology

ABSTRACT Support is requested for a Keystone Symposia conference entitled Progress in Vaccine Development for Infectious Diseases, organized by Drs. Katalin Kariko, Karin Loré and Norbert Pardi. The conference will be held in Breckenridge, Colorado from June 1-4, 2022. Vaccines are the cornerstones of modern medicine, saving millions of lives every year. Due to the fast progress in better understanding the biology of certain pathogens coupled with recent technological advances in the fields of immunology, structural biology and nanomaterial development, science has entered a new golden age of vaccinology. This conference will focus on presenting state-of-the-art vaccine technologies (mRNA, viral vectors, protein nanoparticles, adjuvants), recent advancements in understanding (and potentially manipulating) vaccine-induced immune responses and key aspects of structure-based antigen design that allows us to develop better vaccine immunogens. Combining these overlapping and strongly synergistic aspects of vaccine development will foster collaborations between conference participants that may result in novel, very effective vaccines in the future. Moreover, most of the currently used vaccines have been developed by empirical research without the involvement of immunologists, structural biologists or biomedical engineers. However, it has become evident in recent years that the empirical approach is not sufficient for successful vaccine development against hard-to-target pathogens. To successfully combat these pathogens, the community needs to better understand how to induce protective immune responses against them and need to develop better adjuvants, vaccine platforms or immunization schemes. This "combined" approach requires a tight cooperation between interdisciplinary groups of scientists who will all be in attendance at this Keystone Symposia conference. Finally, the program includes a session focused on vaccine diplomacy, to address key challenges regarding vaccine production and distribution and advocate for a more equitable system for worldwide vaccine distribution.

抽象的 请求支持Keystone研讨会会议，题为“疫苗开发方面的进展” 传染病，由Drs组织。 Katalin Kariko，KarinLoré和Norbert Pardi。会议将是 2022年6月1日至4日在科罗拉多州的布雷肯里奇举行。 疫苗是现代医学的基石，每年挽救数百万生命。由于快速 更好地了解某些病原体的生物学以及最近的技术进步的进步 在免疫学，结构生物学和纳米材料发展领域，科学已经进入了新的 疫苗学的黄金时代。这次会议将着重于介绍最先进的疫苗技术 （mRNA，病毒载体，蛋白质纳米颗粒，调节器），最新理解的进步（并可能 操纵）疫苗诱导的免疫反应和基于结构的抗原设计的关键方面 允许我们开发更好的疫苗免疫原。结合这些重叠和强烈的协同作用 疫苗开发的各个方面将促进会议参与者之间的合作 新颖的，非常有效的疫苗。而且，大多数当前使用的疫苗已经 由经验研究开发，没有免疫学家，结构生物学家或生物医学的参与 工程师。但是，近年来已经证明了经验方法不足 成功开发了针对难以靶标的病原体的疫苗开发。为了成功打击这些病原体， 社区需要更好地理解如何对其诱导保护免疫反应并需要 为了开发更好的佐剂，疫苗平台或免疫方案。这种“组合”方法需要 跨学科的科学家群体之间的紧密合作，他们都会参加此基石 研讨会会议。最后，该计划包括一个专注于疫苗外交的会议，以解决关键 有关疫苗生产和分销的挑战，并提倡更公平的系统 全球疫苗分布。