Progress in Vaccine Development for Infectious Diseases

摘要 请求为题为#年疫苗开发进展的Keystone研讨会提供支助 传染病，由Katalin Kariko博士、Karin Loré博士和Norbert Pardi博士组织。会议将于 2022年6月1日至4日在科罗拉多州布雷肯里奇举行。 疫苗是现代医学的基石，每年拯救数百万人的生命。由于速度很快 在更好地了解某些病原体的生物学方面取得的进展，以及最近的技术进步 在免疫学、结构生物学和纳米材料开发领域，科学已经进入了一个新的 疫苗学的黄金时代。本次会议将集中展示最先进的疫苗技术。 (信使核糖核酸、病毒载体、蛋白质纳米粒子、佐剂)、理解的最新进展(以及潜在的 操纵)疫苗诱导的免疫反应和基于结构的抗原设计的关键方面 使我们能够开发出更好的疫苗免疫原。将这些重叠和强烈的协同作用结合起来 疫苗开发的各个方面将促进与会者之间的合作，这可能导致 新的，非常有效的疫苗在未来。此外，目前使用的大多数疫苗都是 在没有免疫学家、结构生物学家或生物医学专家参与的情况下进行的实证研究 工程师。然而，近年来明显的是，经验主义的方法不足以 成功研制出针对难以瞄准的病原体的疫苗。为了成功地对抗这些病原体， 社区需要更好地了解如何诱导针对它们的保护性免疫反应，并需要 开发更好的佐剂、疫苗平台或免疫方案。这种“组合”方法需要一个 跨学科科学家小组之间的密切合作，他们都将出席这一基石 座谈会。最后，该计划包括一个以疫苗外交为重点的会议，以解决关键问题 在疫苗生产和分配方面的挑战，并倡导建立一个更公平的制度 在全球范围内分发疫苗。

ABSTRACT Support is requested for a Keystone Symposia conference entitled Progress in Vaccine Development for Infectious Diseases, organized by Drs. Katalin Kariko, Karin Loré and Norbert Pardi. The conference will be held in Breckenridge, Colorado from June 1-4, 2022. Vaccines are the cornerstones of modern medicine, saving millions of lives every year. Due to the fast progress in better understanding the biology of certain pathogens coupled with recent technological advances in the fields of immunology, structural biology and nanomaterial development, science has entered a new golden age of vaccinology. This conference will focus on presenting state-of-the-art vaccine technologies (mRNA, viral vectors, protein nanoparticles, adjuvants), recent advancements in understanding (and potentially manipulating) vaccine-induced immune responses and key aspects of structure-based antigen design that allows us to develop better vaccine immunogens. Combining these overlapping and strongly synergistic aspects of vaccine development will foster collaborations between conference participants that may result in novel, very effective vaccines in the future. Moreover, most of the currently used vaccines have been developed by empirical research without the involvement of immunologists, structural biologists or biomedical engineers. However, it has become evident in recent years that the empirical approach is not sufficient for successful vaccine development against hard-to-target pathogens. To successfully combat these pathogens, the community needs to better understand how to induce protective immune responses against them and need to develop better adjuvants, vaccine platforms or immunization schemes. This "combined" approach requires a tight cooperation between interdisciplinary groups of scientists who will all be in attendance at this Keystone Symposia conference. Finally, the program includes a session focused on vaccine diplomacy, to address key challenges regarding vaccine production and distribution and advocate for a more equitable system for worldwide vaccine distribution.