Neuronal Control of Appetite

食欲的神经元控制

基本信息

批准号：
10468571
负责人：
Thale Cross Jarvis
金额：
$ 2万
依托单位：
KEYSTONE SYMPOSIA
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-02-01 至 2022-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10468571
关键词：
Adaptive Behaviors Address Affect Alberta province Animal Model Area Behavioral Biological Body Weight Brain Collaborations Complex Consumption Desire for food Development Eating Eating Behavior Educational workshop Energy Metabolism Ensure Environment Epidemic Equilibrium Event Feedback Feeding behaviors Food Food Energy Food Intake Regulation Future Geography Individual Knowledge Metabolic Diseases Metabolism Methodology Methods Modeling Modernization Motivation Neurons Neurophysiology - biologic function Neurosecretory Systems Nutrient Organizational Change Outcome Participant Pathologic Pattern Physiological Process Psychological Factors Regulation Research Research Personnel Rewards Scientist Sensory Signal Transduction System Systems Development Therapeutic Intervention Work career career development clinical practice clinically relevant design energy balance feeding food consumption gut-brain axis human model interest meetings motivated behavior multidisciplinary neural network neurodevelopment neuroinflammation obesity management posters pressure relating to nervous system response symposium therapeutically effective

项目摘要

ABSTRACT Support is requested for a Keystone Symposia conference entitled Neuronal Control of Appetite, organized by Drs. Richard Simerly, J. Nicholas Betley and Stephanie Fulton. The conference will be held in Banff, Alberta from March 20-23, 2022. How the brain coordinates multiple physiological and environmental signals to regulate body weight remains an important and actively investigated biological question. Moreover, the answer to this question has direct clinical relevance to the management of obesity; most of research in this area has focused, appropriately, on neuroendocrine regulation of food intake and energy expenditure. This Keystone Symposia conference was designed to the present the most cutting-edge findings in the field, which will further expand our understanding of energy balance regulation within the context of motivated behavior. In a dynamic world, the decision to consume food is made after weighing competing needs that also must be addressed to ensure survival as individuals seek, consume and store energy. Additionally, neural systems also reward inappropriate food intake. This conference will focus on the progress being done at both the circuit and systems level, in humans and animal models, to understand how and when food intake is prioritized, how the brain integrates relevant sensory information, balances competing needs, and coordinates adaptive behavior and associated physiological responses to effectively manage energy balance. This conference will also explore development of the neural systems that accomplish these integrative processes. Other sessions will examine how environmental and interoceptive signals, as well as neuroinflammation, can change the organization and function of these neural systems. A diverse array of experimental approaches will be reviewed that both support and challenge current concepts of energy balance regulation and promise to provide a rich framework for discussion and collaboration. Finally, this meeting is being paired with the Keystone Symposia conference, Gut Brain Axis. The meetings will share sessions and provide an optimal venue for participants across both conferences to interact and develop new collaborations across these fields.

抽象的请求支持Keystone研讨会会议，标题为“食欲的神经元控制”，由博士。 Richard Simerly，J。NicholasBetley和Stephanie Fulton。会议将在艾伯塔省班夫举行从2022年3月20日至23日。大脑如何协调多个生理和环境信号来调节体重仍然是重要且积极研究的生物学问题。而且，这个问题的答案是直接的与肥胖管理的临床相关性；该领域的大多数研究都适当地关注食物摄入和能量消耗的神经内分泌调节。这次Keystone研讨会会议是设计为当前该领域最前沿的发现，这将进一步扩大我们的理解在动机行为的背景下的能量平衡调节。在一个充满活力的世界中，决定在称重竞争需求之后，还必须解决食物，以确保生存为个人寻求，消费和储存能量。此外，神经系统还奖励不适当的食物进气。这次会议将重点介绍在人类的电路和系统层面上取得的进展和动物模型，了解如何以及何时确定食物的优先级，大脑如何整合相关感官信息，平衡竞争需求，并协调适应性行为和相关性生理反应有效地管理能量平衡。这次会议还将探索发展完成这些综合过程的神经系统。其他会议将研究如何环境和感知信号以及神经炎症，可以改变组织，并这些神经系统的功能。将审查各种各样的实验方法支持和挑战当前的能源平衡监管概念，并承诺提供丰富的框架进行讨论与协作。最后，这次会议与Keystone研讨会会议配对，肠脑轴。会议将分享会议，并为两者的参与者提供最佳的场地会议互动和开发这些领域的新合作。