Neuronal Control of Appetite

食欲的神经元控制

• 批准号: 10468571
• 负责人: Thale Cross Jarvis
• 金额: $ 2万
• 依托单位: KEYSTONE SYMPOSIA
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-02-01 至 2022-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10468571
• 关键词: Adaptive Behaviors; Address; Affect; Alberta province; Animal Model; Area; Behavioral; Biological; Body Weight; Brain; Collaborations; Complex; Consumption; Desire for food; Development; Eating; Eating Behavior; Educational workshop; Energy Metabolism; Ensure; Environment; Epidemic; Equilibrium; Event; Feedback; Feeding behaviors; Food; Food Energy; Food Intake Regulation; Future; Geography; Individual; Knowledge; Metabolic Diseases; Metabolism; Methodology; Methods; Modeling; Modernization; Motivation; Neurons; Neurophysiology - biologic function; Neurosecretory Systems; Nutrient; Organizational Change; Outcome; Participant; Pathologic; Pattern; Physiological; Process; Psychological Factors; Regulation; Research; Research Personnel; Rewards; Scientist; Sensory; Signal Transduction; System; Systems Development; Therapeutic Intervention; Work; career; career development; clinical practice; clinically relevant; design; energy balance; feeding; food consumption; gut-brain axis; human model; interest; meetings; motivated behavior; multidisciplinary; neural network; neurodevelopment; neuroinflammation; obesity management; posters; pressure; relating to nervous system; response; symposium; therapeutically effective

ABSTRACT Support is requested for a Keystone Symposia conference entitled Neuronal Control of Appetite, organized by Drs. Richard Simerly, J. Nicholas Betley and Stephanie Fulton. The conference will be held in Banff, Alberta from March 20-23, 2022. How the brain coordinates multiple physiological and environmental signals to regulate body weight remains an important and actively investigated biological question. Moreover, the answer to this question has direct clinical relevance to the management of obesity; most of research in this area has focused, appropriately, on neuroendocrine regulation of food intake and energy expenditure. This Keystone Symposia conference was designed to the present the most cutting-edge findings in the field, which will further expand our understanding of energy balance regulation within the context of motivated behavior. In a dynamic world, the decision to consume food is made after weighing competing needs that also must be addressed to ensure survival as individuals seek, consume and store energy. Additionally, neural systems also reward inappropriate food intake. This conference will focus on the progress being done at both the circuit and systems level, in humans and animal models, to understand how and when food intake is prioritized, how the brain integrates relevant sensory information, balances competing needs, and coordinates adaptive behavior and associated physiological responses to effectively manage energy balance. This conference will also explore development of the neural systems that accomplish these integrative processes. Other sessions will examine how environmental and interoceptive signals, as well as neuroinflammation, can change the organization and function of these neural systems. A diverse array of experimental approaches will be reviewed that both support and challenge current concepts of energy balance regulation and promise to provide a rich framework for discussion and collaboration. Finally, this meeting is being paired with the Keystone Symposia conference, Gut Brain Axis. The meetings will share sessions and provide an optimal venue for participants across both conferences to interact and develop new collaborations across these fields.

抽象的 请求支持题为“食欲的神经元控制”的 Keystone 研讨会，该会议由 博士。理查德·西默利、J·尼古拉斯·贝特利和斯蒂芬妮·富尔顿。会议将在艾伯塔省班夫举行 2022 年 3 月 20 日至 23 日。 大脑如何协调多种生理和环境信号来调节体重仍然是一个问题 重要且积极研究的生物学问题。而且这个问题的答案很直接 与肥胖管理的临床相关性；该领域的大多数研究都适当地集中于 食物摄入和能量消耗的神经内分泌调节。本次 Keystone 研讨会是 旨在呈现该领域最前沿的发现，这将进一步扩大我们的理解 动机行为背景下的能量平衡调节。在动态的世界中，决定 消费食物是在权衡竞争需求后做出的，也必须解决这些需求以确保生存 个人寻求、消耗和储存能量。此外，神经系统也会奖励不适当的食物 摄入量。本次会议将重点关注人类在电路和系统层面取得的进展 和动物模型，以了解如何以及何时优先考虑食物摄入，大脑如何整合相关的 感官信息，平衡相互竞争的需求，协调适应性行为和相关的行为 有效管理能量平衡的生理反应。本次会议还将探讨发展 完成这些整合过程的神经系统。其他会议将探讨如何 环境和内感受信号以及神经炎症可以改变组织和 这些神经系统的功能。将审查各种不同的实验方法，以确保 支持和挑战当前的能量平衡调节概念，并承诺提供丰富的框架 进行讨论和协作。最后，这次会议与 Keystone Symposia 会议配对， 肠脑轴。会议将分享会议内容，并为双方参与者提供最佳场所 会议以在这些领域进行互动并发展新的合作。