Neuronal Control of Appetite

摘要 要求为题为“食欲的神经元控制”的Keystone专题讨论会提供支助， Drs. Richard Simerly，J. Nicholas Betley和Stephanie富尔顿.会议将在阿尔伯塔的班夫举行 2022年3月20日至23日。 大脑如何协调多种生理和环境信号来调节体重仍然是一个问题。 重要和积极研究的生物学问题。此外，这个问题的答案是直接的。 肥胖管理的临床相关性;该领域的大多数研究都集中在适当的 食物摄入和能量消耗的神经内分泌调节。这次Keystone研讨会是 旨在呈现该领域最前沿的发现，这将进一步扩大我们的理解 在动机行为的背景下，能量平衡调节。在一个动态的世界里， 消费食物是在权衡竞争需求之后做出的，这些需求也必须得到解决，以确保生存， 个人寻求、消耗和储存能量。此外，神经系统也会奖励不适当的食物。 摄入本次会议将重点讨论在电路和系统层面上所做的进展， 和动物模型，以了解如何以及何时优先考虑食物摄入，大脑如何整合相关信息 感官信息，平衡竞争需求，协调适应行为和相关的 生理反应，以有效地管理能量平衡。本次大会还将探讨发展 完成这些整合过程的神经系统。其他会议将审查如何 环境和内感受信号以及神经炎症可以改变组织， 这些神经系统的功能。一系列不同的实验方法将被审查， 支持和挑战当前能源平衡调节概念，并承诺提供一个丰富的框架 进行讨论和合作。最后，这次会议将与基石研讨会会议配对， 肠脑轴。会议将分享会议，并为双方的参与者提供最佳场所。 会议，以互动和发展跨这些领域的新合作。

ABSTRACT Support is requested for a Keystone Symposia conference entitled Neuronal Control of Appetite, organized by Drs. Richard Simerly, J. Nicholas Betley and Stephanie Fulton. The conference will be held in Banff, Alberta from March 20-23, 2022. How the brain coordinates multiple physiological and environmental signals to regulate body weight remains an important and actively investigated biological question. Moreover, the answer to this question has direct clinical relevance to the management of obesity; most of research in this area has focused, appropriately, on neuroendocrine regulation of food intake and energy expenditure. This Keystone Symposia conference was designed to the present the most cutting-edge findings in the field, which will further expand our understanding of energy balance regulation within the context of motivated behavior. In a dynamic world, the decision to consume food is made after weighing competing needs that also must be addressed to ensure survival as individuals seek, consume and store energy. Additionally, neural systems also reward inappropriate food intake. This conference will focus on the progress being done at both the circuit and systems level, in humans and animal models, to understand how and when food intake is prioritized, how the brain integrates relevant sensory information, balances competing needs, and coordinates adaptive behavior and associated physiological responses to effectively manage energy balance. This conference will also explore development of the neural systems that accomplish these integrative processes. Other sessions will examine how environmental and interoceptive signals, as well as neuroinflammation, can change the organization and function of these neural systems. A diverse array of experimental approaches will be reviewed that both support and challenge current concepts of energy balance regulation and promise to provide a rich framework for discussion and collaboration. Finally, this meeting is being paired with the Keystone Symposia conference, Gut Brain Axis. The meetings will share sessions and provide an optimal venue for participants across both conferences to interact and develop new collaborations across these fields.