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Center for Central Nervous System Function

中枢神经系统功能中心

基本信息

批准号：
10475694
负责人：
JEROME N SANES
金额：
$ 243.34万
依托单位：
BROWN UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-08-15 至 2024-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10475694
关键词：
Affect Affective American Anxiety Area Attention Award Behavior Behavioral Biological Models Brain Brain imaging Centers of Research Excellence Client Cognition Cognitive Communities Computational Biology Decision Making Disease Distant Ensure Event Experimental Animal Model Experimental Designs Faculty Faculty Recruitment Failure Family Foundations Functional Magnetic Resonance Imaging Functional disorder Funding Genetic Goals Grant Health Human Human Resources Impairment Individual Institutes Internet Knowledge Laboratories Learning Mediating Mental disorders Mentors Methods Molecular Monitor Neocortex Nervous System Physiology Neuraxis Pattern Perception Phase Pilot Projects Positioning Attribute Preparation Privatization Procedures Process Production Psyche structure Publications Publishing Research Research Activity Research Infrastructure Research Personnel Research Project Grants Research Support Resources Rhode Island Role Rotation Schedule Science Sensory Signal Transduction Site Source Structure Technology Training and Infrastructure United States United States National Institutes of Health Universities Work anxiety-related disorders base career development cognitive neuroscience community based participatory research computerized tools cost design experimental analysis faculty mentor falls human disease magnetic resonance imaging/electroencephalography member mid-career faculty mind control multimodality neocortical nervous system disorder neuroimaging neuromechanism neurotransmission nonhuman primate novel operation programs recruit relating to nervous system research and development senior faculty sensory stimulus skills social success tool

项目摘要

Purposeful human behavior requires attention, decisions and construction and production of abstract sequences, all basic functions mediated by brain networks primarily located in the neocortex, but modulated and shaped by sub-cortical processing. In a general and even a specific sense, attention, decision making and production of abstract sequences are key components of human mental activities. Deficits in these functions are common in both neurological and psychiatric disorders and can result in a wide range of higher-order behavioral deficits, including anxiety. We propose to continue, for at least another five years, the COBRE Center for Central Nervous System Function at Brown University that will investigate the mechanisms of higher-brain function focusing on decision making, abstract sequence construction and attention, while developing statistically valid tools to reveal brain connectivity pattern. This COBRE consists of four research projects led by junior faculty and one by an established investigator. Shenhav will investigate brain mechanisms of cognitive interference during value based decision using multi-modal brain recordings. Desrochers will investigate the neural basis of sequence monitoring in humans and non-human primates using neuroimaging and circuit disruption. FeldmanHall will examine the neural and affective mechanisms of socially risky learning using neuroimaging and behavior. Eloyan will develop quantitative methods for brain connectivity network estimation and inference using functional MRI signals. Jones will investigate the causal role of neocortical beta events in human sensory perception. A Design and Analysis Core and a Behavior and Neuroimaging Core will facilitate the research goals of these projects and benefit the broader Brown community by developing new tools and optimizing existing ones to image brain structure and function with MRI and EEG, while insuring proper experimental design and analysis procedures across the projects. Project Leaders will have senior faculty mentors who will provide support and guidance on research, publication, grant preparation, and career development. An Administrative Core will oversee the operations of this COBRE Center. The COBRE Center for Central Nervous System Function will fall under the auspices of the Brown Institute for Brain Science. The COBRE Center will leverage the administrative resources available through the Brown Institute for Brain Science to ensure efficient operation and coordinate with other brain science research activities at Brown.

有目的的人类行为需要注意力、决策以及抽象的构建和产生序列，所有基本功能均由主要位于新皮质的大脑网络介导，但受到调节并通过皮层下加工来塑造。在一般甚至特定意义上，注意力、决策和抽象序列的产生是人类心理活动的关键组成部分。这些功能的缺陷在神经和精神疾病中都很常见，并且可以导致广泛的高阶疾病行为缺陷，包括焦虑。我们建议继续实施 COBRE 至少五年布朗大学中枢神经系统功能中心将研究其机制高级大脑功能专注于决策、抽象序列构建和注意力，而开发统计上有效的工具来揭示大脑连接模式。该 COBRE 包括四项研究项目由初级教师领导，一个由资深研究员领导。 Shenhav 将研究大脑使用多模式大脑记录进行基于价值的决策期间的认知干扰机制。 Desrochers 将使用以下方法研究人类和非人类灵长类动物序列监测的神经基础神经影像学和电路中断。 FeldmanHall 将研究社交的神经和情感机制使用神经影像学和行为进行危险学习。 Eloyan 将开发大脑连接的定量方法使用功能 MRI 信号进行网络估计和推理。琼斯将调查因果关系人类感官知觉中的新皮质β事件。设计和分析核心以及行为和神经影像核心将促进这些项目的研究目标，并使更广泛的布朗大学受益社区通过开发新工具并优化现有工具来对大脑结构和功能进行成像 MRI 和 EEG，同时确保整个项目的实验设计和分析程序正确。项目领导者将拥有高级教师导师，他们将在研究、出版、资助等方面提供支持和指导准备和职业发展。行政核心将监督该 COBRE 的运营中心。 COBRE 中枢神经系统功能中心将由布朗大学赞助脑科学研究所。 COBRE 中心将利用通过以下方式提供的行政资源：布朗脑科学研究所确保高效运行并与其他脑科学研究相协调布朗的活动。