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Center for Central Nervous System Function

中枢神经系统功能中心

基本信息

批准号：
10475694
负责人：
JEROME N SANES
金额：
$ 243.34万
依托单位：
BROWN UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-08-15 至 2024-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10475694
关键词：
Affect Affective American Anxiety Area Attention Award Behavior Behavioral Biological Models Brain Brain imaging Centers of Research Excellence Client Cognition Cognitive Communities Computational Biology Decision Making Disease Distant Ensure Event Experimental Animal Model Experimental Designs Faculty Faculty Recruitment Failure Family Foundations Functional Magnetic Resonance Imaging Functional disorder Funding Genetic Goals Grant Health Human Human Resources Impairment Individual Institutes Internet Knowledge Laboratories Learning Mediating Mental disorders Mentors Methods Molecular Monitor Neocortex Nervous System Physiology Neuraxis Pattern Perception Phase Pilot Projects Positioning Attribute Preparation Privatization Procedures Process Production Psyche structure Publications Publishing Research Research Activity Research Infrastructure Research Personnel Research Project Grants Research Support Resources Rhode Island Role Rotation Schedule Science Sensory Signal Transduction Site Source Structure Technology Training and Infrastructure United States United States National Institutes of Health Universities Work anxiety-related disorders base career development cognitive neuroscience community based participatory research computerized tools cost design experimental analysis faculty mentor falls human disease magnetic resonance imaging/electroencephalography member mid-career faculty mind control multimodality neocortical nervous system disorder neuroimaging neuromechanism neurotransmission nonhuman primate novel operation programs recruit relating to nervous system research and development senior faculty sensory stimulus skills social success tool

项目摘要

Purposeful human behavior requires attention, decisions and construction and production of abstract sequences, all basic functions mediated by brain networks primarily located in the neocortex, but modulated and shaped by sub-cortical processing. In a general and even a specific sense, attention, decision making and production of abstract sequences are key components of human mental activities. Deficits in these functions are common in both neurological and psychiatric disorders and can result in a wide range of higher-order behavioral deficits, including anxiety. We propose to continue, for at least another five years, the COBRE Center for Central Nervous System Function at Brown University that will investigate the mechanisms of higher-brain function focusing on decision making, abstract sequence construction and attention, while developing statistically valid tools to reveal brain connectivity pattern. This COBRE consists of four research projects led by junior faculty and one by an established investigator. Shenhav will investigate brain mechanisms of cognitive interference during value based decision using multi-modal brain recordings. Desrochers will investigate the neural basis of sequence monitoring in humans and non-human primates using neuroimaging and circuit disruption. FeldmanHall will examine the neural and affective mechanisms of socially risky learning using neuroimaging and behavior. Eloyan will develop quantitative methods for brain connectivity network estimation and inference using functional MRI signals. Jones will investigate the causal role of neocortical beta events in human sensory perception. A Design and Analysis Core and a Behavior and Neuroimaging Core will facilitate the research goals of these projects and benefit the broader Brown community by developing new tools and optimizing existing ones to image brain structure and function with MRI and EEG, while insuring proper experimental design and analysis procedures across the projects. Project Leaders will have senior faculty mentors who will provide support and guidance on research, publication, grant preparation, and career development. An Administrative Core will oversee the operations of this COBRE Center. The COBRE Center for Central Nervous System Function will fall under the auspices of the Brown Institute for Brain Science. The COBRE Center will leverage the administrative resources available through the Brown Institute for Brain Science to ensure efficient operation and coordinate with other brain science research activities at Brown.

有目的的人类行为需要关注、决策以及抽象的构建和产生序列，所有基本功能都由大脑网络介导，主要位于新皮质，但受到调制并通过皮质下加工成形。在一般甚至是特定的意义上，关注，决策和抽象序列的产生是人类心理活动的重要组成部分。这些功能的缺陷在神经和精神疾病中都很常见，并可导致广泛的更高级别的行为缺陷，包括焦虑。我们建议，至少再继续五年，科布雷布朗大学中枢神经系统功能中心将研究更高级的大脑功能，专注于决策、抽象序列构建和注意力，而开发统计上有效的工具来揭示大脑连接模式。本文由四项研究组成由初级教员领导的项目和一个由资深调查人员领导的项目。申哈夫将对大脑进行调查多模式脑电记录下基于价值决策的认知干扰机制研究。 Desrocher将研究人类和非人类灵长类动物序列监测的神经基础神经成像和电路中断。费尔德曼·霍尔将研究社会的神经和情感机制使用神经成像和行为的高风险学习。埃洛扬将开发大脑连接的定量方法使用功能磁共振信号进行网络估计和推理。琼斯将调查这一事件的原因人类感官知觉中的新皮质β事件。设计和分析核心、行为和神经成像核心将促进这些项目的研究目标，并使更广泛的布朗受益通过开发新工具和优化现有工具来显示大脑结构和功能 MRI和EEG，同时确保项目中正确的实验设计和分析程序。项目领导者将拥有资深教师导师，他们将在研究、出版、拨款等方面提供支持和指导准备，和职业发展。一个行政核心将监督这个科布雷的运作中心。科布雷中枢神经系统功能中心将由布朗领导脑科学研究所。科布雷中心将利用通过以下途径提供的管理资源布朗脑科学研究所确保高效运行并与其他脑科学研究协调布朗大学的活动。