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Formation of Centromeres in vivo

Formation of Centromeres in vivo
体内着丝粒的形成
批准号：
10486792
负责人：
YAMINI P DALAL
金额：
$35.9万
依托单位：
DIVISION OF BASIC SCIENCES - NCI
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/10486792
关键词：
AddressBinding ProteinsBiochemicalBiological ModelsCell CycleCellsCentromereChromatinChromatin StructureCollaborationsComplexComputer ModelsCryoelectron MicroscopyDataEpigenetic ProcessFundingGenomeGoalsHumanKinetochoresManuscriptsMitoticModificationMolecular ChaperonesNucleosomesPaperPostdoctoral FellowProteinsPublishingStructural ModelsStructureTechnologyUntranslated RNAWorkcentromere protein Acentromere protein Ccomplex datadaughter cellgraduate studentin vivonuclear divisionprotein complexsegregationunpublished works

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中文摘要
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英文摘要
Our goal is to dissect the mechanism by which kinetochore proteins binds the centromeric chromatin in the genome and creates the basis for a functional centromere. We have published a few papers on this work, and have 2 more manuscripts that detail more cenRNAs involved in centromere function. We also have unpublished work with EM and biochemical data demonstrating how CENP-A nucleosomes can be altered in the presence or absence of various proteins. These data demonstrate how various epigenetic factors, namely lncRNAs and kinetochore proteins, can modulate CENP-A structure to uniquely define how functional centromere domains are formed and maintained.
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