Role of histone variants in aging and cancer

组蛋白变异在衰老和癌症中的作用

• 批准号: 10486789
• 负责人: YAMINI P DALAL
• 金额: $ 71.79万
• 依托单位: DIVISION OF BASIC SCIENCES - NCI
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10486789
• 关键词: Address; Adult Glioblastoma; Aging; Area; Automobile Driving; Chromosomal Instability; Chromosomal translocation; Collaborations; Computer Models; Coupled; Epigenetic Process; Failure; Genes; Genome; Glioblastoma; Histones; Human; Lead; Location; Machine Learning; Malignant Neoplasms; Manuscripts; Maps; Microscopy; Organ; Organoids; Outcome; Pathway interactions; Patients; Property; Publications; Publishing; Research Personnel; Resolution; Role; Sampling; Solid; Solid Neoplasm; Specificity; Time; Tissues; Untranslated RNA; Variant; Work; cancer cell; centromere protein A; follow-up; genome-wide; new technology; repaired; small molecule inhibitor; tumor; tumorigenesis; virtual

We are currently focused on analysis of chromosome translocations and mechanisms involved in the breaks and repair machinery involved in the translocations. Using high resolution microscopy coupled to machine learning, we are currently finding new ways to automatically score patient samples for translocations involving the CENP-A domain we mapped in previous publications, and using small molecule inhibitors that can disrupt these pathways. These translocations and amplifications occur in virtually every time of solid tumor we have examined. We have expanded our work significantly to include adult glioblastomas and aging tissues derived from human patients.

我们目前的重点是分析染色体易位和机制涉及的断裂和修复机制涉及的易位。使用高分辨率显微镜结合机器学习，我们目前正在寻找新的方法来自动评分患者样本的易位，涉及我们在以前的出版物中映射的CENP-A结构域，并使用可以破坏这些途径的小分子抑制剂。这些易位和扩增几乎发生在我们检查过的每一个实体瘤中。我们已经将我们的工作显著扩展到包括成人胶质母细胞瘤和来自人类患者的老化组织。