Kinetochore Interaction with Centromere Chromatin in human cells

着丝粒与人体细胞中着丝粒染色质的相互作用

• 批准号: 8157701
• 负责人: YAMINI P DALAL
• 金额: $ 18.97万
• 依托单位: DIVISION OF BASIC SCIENCES - NCI
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8157701
• 关键词: Cells; Centromere; Chromatin; Human; Kinetochores

Our goal is to dissect the mechanism by which kinetochore proteins binds the centromeric chromatin in the genome and creates the basis for a functional centromere. Since the project started by new postdoctoral associate in 2010, this work is in progress. A separate study was conducted in collaboration with a human pluripotent cell (hPSC) investigator Amander Clark (UCLA), where we discovered that the centromeric protein reserve plays a role in cell differentiation and in chromosome damage sensing. This work was published in Human Mol. Genetics August 2010. The follow up project was suspended due to the recent ruling on the use of hPSC in federally funded projects.

我们的目标是剖析着丝粒蛋白与基因组中着丝粒染色质结合的机制，并为功能性着丝粒创造基础。自2010年新聘博士后启动该项目以来，这项工作正在进行中。与人类多能细胞（hPSC）研究者Amander Clark （UCLA）合作进行的另一项研究中，我们发现着丝粒蛋白储备在细胞分化和染色体损伤感知中发挥作用。这项研究发表在2010年8月的《人类遗传》杂志上。由于最近关于在联邦资助的项目中使用hPSC的裁决，后续项目被暂停。