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Genome wide profiling of histone variants in tumors

Genome wide profiling of histone variants in tumors
肿瘤中组蛋白变异的全基因组分析
批准号：
8938009
负责人：
YAMINI P DALAL
金额：
$36.81万
依托单位：
DIVISION OF BASIC SCIENCES - NCI
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/8938009
关键词：
AddressCancer cell lineCentromereChromatin StructureChromosomal InstabilityChromosome Fragile SitesColorectal CancerEpigenetic ProcessFailureFunctional RNAFutureGenesGenomeGoalsHistonesHumanLeadLocationMapsMethodsModificationOutcomePostdoctoral FellowProcessSpecificityVariantWorkcancer cellcentromere protein Afollow-upgenome-widenew technologyresponsetumortumor progressiontumorigenic

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英文摘要
We have mapped unique histone variant genome wide in colorectal cancer cell lines and found that that they cluster at a subset of epigenetically distinctive regions. We have mapped these regions further using cytological methods and discovered a new centromere-like region in a fragile chromosome site encompassing the myc locus. Future goals involve mapping histone variants in tumors in order to track progression of aberrant chromatin structures as a consequence of the tumorigenic process, and discovering remodelers and processes involved in the mis-localization. We are also purifying large quantities of histone variants and examining their modification status in response to tumor progression.
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  • 依托单位：
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  • 批准号：
    7966218
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Kinetochore Interaction with Centromere Chromatin in human cells
  • 批准号：
    8157701
  • 项目类别：
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  • 依托单位：
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