1/1 NADIA U24 Administrative Core

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ABSTRACT 1/1 U24 NADIA ADMINISTRATIVE CORE - SUMMARY This is the second renewal of the Neurobiology of Adolescent Drinking in Adulthood (NADIA) Administrative Core (NADIA Administrative Core-U24, RFA-AA-20-004). The Administrative Core provides organizational and scientific leadership to achieve the goal of our Consortium: to elucidate persistent changes in complex brain function-behavior relationships following adolescent alcohol exposure. Adolescent binge and extreme drinking are common, and while many factors contribute to human brain development and alcohol use during adoles- cence, animal models are critical for understanding the specific consequences of alcohol exposure on the brain and behavior during this crucial developmental period. In the previous funding periods, the NADIA discovered that adolescent intermittent ethanol (AIE) led to multiple behavioral, neurochemical and physiological patholo-gies in adulthood. Mechanistic studies revealed that these AIE-induced changes could be prevented or re-versed by targeting specific neurotransmission, neuroinflammation, or epigenetic regulation of genes. The Consortium has been very productive, as evidenced by our recent literature reviews and over 200 publications. To promote and facilitate continued progress, the NADIA Administrative Core is the main organizational unit of the Consortium and serves as the liaison between the Scientific Core, the eight Research Components, the NADIA Steering Committee, the External Advisory Board, and the NIAAA. The Administrative Core organizes all Consortium activities including retreats, progress reports and External Advisory Board evaluations of cores and components. The Administrative Core ensures consistent and forward progress by facilitating communica-tion and promoting integration of data among the components and cores. The Core develops scientific and conceptual themes as well as recommended operating procedures that cross components. The Core provides a repository for all publications generated by the Consortium. Finally, the Core facilitates dissemination and translation of NADIA-generated data, in part by targeted interactions with the National Consortium on Alcohol and Neurodevelopment in Adolescence (NCANDA) and other alcohol research groups. This NADIA renewal exactly fulfills the molecular mechanism and translation goals of this RFA leading to development of therapeu-tic interventions of adult psychopathologies of adolescent alcohol consumption. Understanding the impact of underage drinking on adult neurobiology is important to guide public health initiatives, and the NADIA Adminis-trative Core creates synergies for such discoveries across the Consortium.