Neuroimmunometabolism: Obesity at the Crossroads between Neuroimmunity and Immunometabolism

摘要 要求支持在2010年12月15日至16日在纽约举行的题为“神经免疫代谢：肥胖”的Keystone专题讨论会。 神经免疫和免疫代谢之间的十字路口，由Ana Domingos和Alan博士组织 萨尔蒂尔会议将于2022年10月7日至10日在科罗拉多州布雷肯里奇举行。 肥胖症是由下丘脑-器官神经元通路，特别是由交感神经， 肝脏和脂肪组织在肥胖症发作时退化。代谢性炎症会促使 自主神经系统或下丘脑内的神经退行性机制使代谢恶化 结果。对调节免疫代谢的神经免疫方面的更深入理解可能 改变我们对针对NASH和肥胖症的药物治疗的看法。而药物输送通过 血脑屏障是一个真实的挑战，靶向神经相关的免疫细胞，这些免疫细胞调节 肝脏、胰腺或脂肪内的神经是一种切实可行的方法。然而，这种可能性依赖于填充 关于控制肝脏、胰腺、棕色和棕色的生理学的神经免疫机制的知识差距 白色脂肪组织。神经免疫对肠道生理学的理解已经取得了很大的进步， 在免疫代谢领域有相似之处。新认识到的机会 神经免疫和免疫代谢领域之间的交叉是巨大的，可能会创造新的 科学知识和治疗进展。

ABSTRACT Support is requested for a Keystone Symposia conference entitled Neuroimmunometabolism: Obesity at the Crossroads between Neuroimmunity and Immunometabolism, organized by Drs. Ana Domingos and Alan Saltiel. The conference will be held in Breckenridge, Colorado from October 7-10, 2022. Adiposity is governed by hypothalamus-organ neuronal pathways, particularly by sympathetic nerves in the liver and adipose tissue that degenerate during the onset of obesity. Metabolic inflammation can prompt neurodegenerative mechanisms within the autonomic nervous system or hypothalamus to worsen metabolic outcomes. A deeper understanding of the neuroimmune aspects that regulate immunometabolism may change the way we think about pharmacologically targeting NASH and obesity. Whereas drug delivery across the blood-brain barrier is a real challenge, targeting nerve-associated immune cells that modulate the output of nerves within the liver, pancreas, or fat is a tangible approach. However, this possibility relies on filling the knowledge gap on the neuroimmune mechanisms governing the physiology of the liver, pancreas, brown and white adipose tissues. The neuroimmune understanding of gut physiology has taken great strides that could have parallels within the immunometabolism field. The opportunity presented by the newly recognized intersections between the fields of neuroimmunity and immunometabolism is gigantic and may create new scientific knowledge and therapeutic advances.