Neuroimmunometabolism: Obesity at the Crossroads between Neuroimmunity and Immunometabolism
Neuroimmunometabolism: Obesity at the Crossroads between Neuroimmunity and Immunometabolism
批准号:
10540258
负责人:
Thale Cross Jarvis
金额:
$2.01万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2022
资助国家:
美国
项目状态:
已结题
起止时间:
2022-08-01 至 2023-07-31
关键词:
AddressAdipose tissueAreaAutonomic nervous systemBlood - brain barrier anatomyBrainCellsCollaborationsColoradoConflict (Psychology)DiseaseDrug Delivery SystemsEducational workshopFatty acid glycerol estersFutureGoalsHeart DiseasesHypothalamic structureImmuneImmunobiologyImmunomodulatorsIndustrializationInflammationKnowledgeLearningLiverMalignant NeoplasmsMetabolicMetabolismMethodologyModelingNerveNerve DegenerationNeural PathwaysNeurodegenerative DisordersNeuroimmuneNeuroimmunomodulationNeuronsNon-Insulin-Dependent Diabetes MellitusObesityObesity associated diseaseOrganOutcomeOutputOverweightPancreasPathway interactionsPersonsPharmacological TreatmentPharmacologyPhysiologyResearchResearch PersonnelScientistSpeedTechnologyTherapeuticTranslationsWorkcareerclinical implementationclinical practicedesignfightinginterdisciplinary approachinterdisciplinary collaborationinterestlearning networkmultidisciplinarynext generationnonalcoholic steatohepatitisobesity treatmentposterspreservationsymposium
中文摘要
摘要
英文摘要
ABSTRACT
Support is requested for a Keystone Symposia conference entitled Neuroimmunometabolism: Obesity at the
Crossroads between Neuroimmunity and Immunometabolism, organized by Drs. Ana Domingos and Alan
Saltiel. The conference will be held in Breckenridge, Colorado from October 7-10, 2022.
Adiposity is governed by hypothalamus-organ neuronal pathways, particularly by sympathetic nerves in the
liver and adipose tissue that degenerate during the onset of obesity. Metabolic inflammation can prompt
neurodegenerative mechanisms within the autonomic nervous system or hypothalamus to worsen metabolic
outcomes. A deeper understanding of the neuroimmune aspects that regulate immunometabolism may
change the way we think about pharmacologically targeting NASH and obesity. Whereas drug delivery across
the blood-brain barrier is a real challenge, targeting nerve-associated immune cells that modulate the output of
nerves within the liver, pancreas, or fat is a tangible approach. However, this possibility relies on filling the
knowledge gap on the neuroimmune mechanisms governing the physiology of the liver, pancreas, brown and
white adipose tissues. The neuroimmune understanding of gut physiology has taken great strides that could
have parallels within the immunometabolism field. The opportunity presented by the newly recognized
intersections between the fields of neuroimmunity and immunometabolism is gigantic and may create new
scientific knowledge and therapeutic advances.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Bioenergetics in Health and Diseases
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批准号:10609120
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项目类别:
-
资助金额:$1.74万
-
财政年份:2023
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负责人:Thale Cross Jarvis
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依托单位:
Autophagy and Neurodegeneration: Mechanisms to Therapies
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批准号:10608666
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项目类别:
-
资助金额:$1.5万
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财政年份:2023
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负责人:Thale Cross Jarvis
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依托单位:
Adipose Tissue: Energizing Good Fat
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批准号:10609127
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项目类别:
-
资助金额:$2.02万
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财政年份:2023
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负责人:Thale Cross Jarvis
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依托单位:
Cancer Neoantigens, Vaccines and Viruses
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批准号:10233861
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项目类别:
-
资助金额:$0.5万
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财政年份:2022
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负责人:Thale Cross Jarvis
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依托单位:
Small Regulatory RNAs: From Bench to Bedside
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批准号:10462420
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项目类别:
-
资助金额:$0.5万
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财政年份:2022
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负责人:Thale Cross Jarvis
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依托单位:
Engineering Multi-Cellular Living Systems
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批准号:10462913
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项目类别:
-
资助金额:$1.5万
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财政年份:2022
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负责人:Thale Cross Jarvis
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依托单位:
Malaria: Confronting Challenges From Drug Discovery to Treatment
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批准号:10468493
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项目类别:
-
资助金额:$0.5万
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财政年份:2022
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负责人:Thale Cross Jarvis
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依托单位:
Gut-Brain Axis
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批准号:10467819
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项目类别:
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资助金额:$1.72万
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财政年份:2022
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负责人:Thale Cross Jarvis
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依托单位:
The Human Microbiome: Ecology and Evolution
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批准号:10391370
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项目类别:
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资助金额:$0.5万
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财政年份:2022
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负责人:Thale Cross Jarvis
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依托单位:
Modern Phenotypic Drug Discovery: From Chemical Biology to Therapeutics
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批准号:10468419
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项目类别:
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资助金额:$1.72万
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财政年份:2022
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负责人:Thale Cross Jarvis
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依托单位:
Progress in Vaccine Development for Infectious Diseases
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批准号:10467880
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项目类别:
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资助金额:$0.55万
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财政年份:2022
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负责人:Thale Cross Jarvis
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依托单位:
Tissue Fibrosis and Repair: Mechanisms, Human Disease and Therapies
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批准号:10462412
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项目类别:
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资助金额:$1.8万
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财政年份:2022
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负责人:Thale Cross Jarvis
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依托单位:
Drug Delivery to the Brain: Challenges and Progress
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批准号:10540503
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项目类别:
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资助金额:$1.77万
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财政年份:2022
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负责人:Thale Cross Jarvis
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依托单位:
Neurocircuitry of Social Behavior
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批准号:10540465
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项目类别:
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资助金额:$1.2万
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财政年份:2022
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负责人:Thale Cross Jarvis
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依托单位:
Resolution of Inflammation
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批准号:10469175
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项目类别:
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资助金额:$0.9万
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财政年份:2022
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负责人:Thale Cross Jarvis
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依托单位:
Organoids as Tools for Fundamental Discovery and Translation
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批准号:10469084
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项目类别:
-
资助金额:$1.5万
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财政年份:2022
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负责人:Thale Cross Jarvis
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依托单位:
Novel Approaches Against Emerging Antimicrobial Resistance
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批准号:10391767
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项目类别:
-
资助金额:$1.1万
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财政年份:2022
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负责人:Thale Cross Jarvis
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依托单位:
Precision Genome Engineering
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批准号:10391367
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项目类别:
-
资助金额:$2.22万
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财政年份:2022
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负责人:Thale Cross Jarvis
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依托单位:
Neuronal Control of Appetite
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批准号:10468571
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项目类别:
-
资助金额:$2.0万
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财政年份:2022
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负责人:Thale Cross Jarvis
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依托单位:
Innate Immunity: Complement and Beyond
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批准号:10464340
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项目类别:
-
资助金额:$1.1万
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财政年份:2022
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负责人:Thale Cross Jarvis
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依托单位:
海外基金