Neuroimmunometabolism: Obesity at the Crossroads between Neuroimmunity and Immunometabolism

摘要

ABSTRACT Support is requested for a Keystone Symposia conference entitled Neuroimmunometabolism: Obesity at the Crossroads between Neuroimmunity and Immunometabolism, organized by Drs. Ana Domingos and Alan Saltiel. The conference will be held in Breckenridge, Colorado from October 7-10, 2022. Adiposity is governed by hypothalamus-organ neuronal pathways, particularly by sympathetic nerves in the liver and adipose tissue that degenerate during the onset of obesity. Metabolic inflammation can prompt neurodegenerative mechanisms within the autonomic nervous system or hypothalamus to worsen metabolic outcomes. A deeper understanding of the neuroimmune aspects that regulate immunometabolism may change the way we think about pharmacologically targeting NASH and obesity. Whereas drug delivery across the blood-brain barrier is a real challenge, targeting nerve-associated immune cells that modulate the output of nerves within the liver, pancreas, or fat is a tangible approach. However, this possibility relies on filling the knowledge gap on the neuroimmune mechanisms governing the physiology of the liver, pancreas, brown and white adipose tissues. The neuroimmune understanding of gut physiology has taken great strides that could have parallels within the immunometabolism field. The opportunity presented by the newly recognized intersections between the fields of neuroimmunity and immunometabolism is gigantic and may create new scientific knowledge and therapeutic advances.