Neuroimmunometabolism: Obesity at the Crossroads between Neuroimmunity and Immunometabolism

摘要 请求支持Keystone研讨会，题为神经免疫代谢：肥胖 神经免疫和免疫新陈代谢的十字路口，由Ana Domingos博士和Alan博士组织 萨尔蒂尔。大会将于2022年10月7日至10日在科罗拉多州布雷肯里奇举行。 肥胖是由下丘脑-器官神经通路控制的，尤其是由 在肥胖开始时退化的肝脏和脂肪组织。代谢性炎症会促使 自主神经系统或下丘脑内导致代谢恶化的神经退行性机制 结果。对调节免疫新陈代谢的神经免疫方面的深入了解可能会 改变我们对药物治疗NASH和肥胖症的看法。而跨境药物输送 血脑屏障是一个真正的挑战，它针对的是调节血管生成的神经相关免疫细胞。 肝脏、胰腺或脂肪中的神经是一种切实的方法。然而，这种可能性依赖于填充 关于支配肝、胰腺、棕色和卵巢生理的神经免疫机制的知识差距 白色脂肪组织。神经免疫对肠道生理的理解已经取得了长足的进步，这可能 在免疫代谢领域有相似之处。新认识到的机遇 神经免疫和免疫代谢领域的交叉是巨大的，可能会创造新的 科学知识和治疗进展。

ABSTRACT Support is requested for a Keystone Symposia conference entitled Neuroimmunometabolism: Obesity at the Crossroads between Neuroimmunity and Immunometabolism, organized by Drs. Ana Domingos and Alan Saltiel. The conference will be held in Breckenridge, Colorado from October 7-10, 2022. Adiposity is governed by hypothalamus-organ neuronal pathways, particularly by sympathetic nerves in the liver and adipose tissue that degenerate during the onset of obesity. Metabolic inflammation can prompt neurodegenerative mechanisms within the autonomic nervous system or hypothalamus to worsen metabolic outcomes. A deeper understanding of the neuroimmune aspects that regulate immunometabolism may change the way we think about pharmacologically targeting NASH and obesity. Whereas drug delivery across the blood-brain barrier is a real challenge, targeting nerve-associated immune cells that modulate the output of nerves within the liver, pancreas, or fat is a tangible approach. However, this possibility relies on filling the knowledge gap on the neuroimmune mechanisms governing the physiology of the liver, pancreas, brown and white adipose tissues. The neuroimmune understanding of gut physiology has taken great strides that could have parallels within the immunometabolism field. The opportunity presented by the newly recognized intersections between the fields of neuroimmunity and immunometabolism is gigantic and may create new scientific knowledge and therapeutic advances.