HIGH SPEED MRI TUMOR IMAGING

高速 MRI 肿瘤成像

• 批准号: 2094041
• 负责人: ALBERT MACOVSKI
• 金额: $ 25.97万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-01-04 至 1998-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2094041
• 关键词: abdomen neoplasm; fluoroscopy; human subject; image processing; magnetic resonance imaging; method development; neoplasm /cancer diagnosis

Due to recent breakthroughs in fast imaging techniques and hardware MRI now has the potential to surpass CT for diagnosing abdominal tumors. MRI has two fundamental advantages: it lacks ionizing radiation, and it shows superior soft tissue contrast. The disadvantages of conventional MRI are sensitivity to motion and inferior resolution. The work proposed here directly addresses these challenges. During the first phase of this grant we have developed several new rapid imaging techniques that clearly have the potential to make tumor imaging in the abdomen a viable clinical tool. These include high-speed interleaved spiral sequences that provide the necessary sensitivity, immunity to motion, and contrast for clinical imaging of tumors in the abdomen. This potential has been vividly confirmed after imaging over 50 patients and many more normal volunteers. These techniques include a novel RARE-spiral sequence that promises improved SNR and resolution. In addition we have studied several volumetric sequences in which 3D kappa- space is scanned efficiently and with insensitivity to motion. We have developed several fluoroscopic sequences to enable critical dynamic studies. For uncooperative patients who cannot hold their breath, we have developed a non-breath-held sequence using navigator-based motion detection system that in real time reacquires all data corrupted by excessive motion. In this renewal we propose to continue developing several important abdominal imaging protocols and also several core techniques critical to high speed imaging with time-varying gradients. Ultimately, this body of work will produce a suite of optimized clinical protocols including breath-held T/1 and T/2 weighted sequences, non-breath-held, motion- compensated T/1 and T/2 weighted sequences, and a fluoroscopic sequence. Although these are designed for current hardware, each can be adapted to exploit the capabilities of the next generation of gradient and RF hardware currently being released. The new protocols and core techniques will be optimized using anecdotal clinical scans.

由于最近在快速成像技术和硬件MRI方面的突破 现在在诊断腹部肿瘤方面有超过CT的潜力。磁共振成像 有两个基本优势：它没有电离辐射，而且它表明 良好的软组织对比度。常规磁共振成像的缺点是 对运动敏感，分辨率较低。在这里提出的工作 直接应对这些挑战。 在这笔赠款的第一阶段，我们开发了几个新的快速 显然有可能使肿瘤成像的成像技术 腹部是一种可行的临床工具。其中包括高速 提供必要灵敏度的交错螺旋序列， 对运动的免疫力和对比度用于临床肿瘤的成像 腹部。这种潜力在经过50多年的成像后得到了生动的证实 病人和更多的正常志愿者。这些技术包括 新的稀有螺旋序列，承诺改善信噪比和分辨率。在……里面 此外，我们还研究了几种体积序列，在这些序列中，3Dkappa- 空间被有效地扫描，并且对运动不敏感。我们有 开发了几种透视序列，以实现关键的动态 学习。对于不能屏息的不合作的患者，我们有 开发了一个使用基于导航器的运动的非屏气序列 检测系统，可实时重新获取所有被 过度运动。 在这次更新中，我们建议继续开发几个重要的 腹部成像方案以及几项关键的核心技术 具有时变梯度的高速成像。归根结底，这个机构 这项工作将产生一套优化的临床方案，包括 屏气T/1和T/2加权序列，非屏气，运动- 补偿的T/1和T/2加权序列，以及透视序列。 虽然它们都是为当前的硬件设计的，但每一个都可以适应 利用下一代梯度和射频的功能 硬件目前正在发布。新协议和核心技术 将使用轶事临床扫描进行优化。