MAGNETOENCEPHALOGRAPHY IN EPILEPSY

我们已经完成了拨款目标的五分之三，使 研究的5个步骤都取得了进展。我们将完成主要目标。 在授予赠款的时间内获得赠款。七频道 磁力计、屏蔽室和PPI在 使用PPI对MEG、EEG、ECoG和MR扫描使用相同的基准坐标 &lt；1 mm的分辨率，自发辐射的极佳信噪比 尖峰和癫痫发作，以及特殊共面的足够空间覆盖 宽梯度计六边形，用于捕获相位反转和零点 同时进行ECoG时出现自发性癫痫发作和棘波。我们已经研究过 大量事件发生在更多的患者身上。我们已经确定了一个 对每个患者的综合研究提高了定位精度和 比较和更大的患者样本量是必要的 进一步的假设。我们将在5个步骤中的每一步中扩展研究 接近。我们建议研究更多的完整的患者 植入偶极子的脑磁图、EEG和ECoG的研究、诱发反应和 每个患者都有自发的尖峰和癫痫发作。我们想要调查 尖峰和癫痫的传播模式，以获得更准确的 癫痫区域的量化，对外科手术具有潜在的重要意义 治疗。我们计划将7-60个脑电通道与37-60个脑电通道进行比较 确定大型阵列MEG系统附加值的渠道和 升级到一阶导数梯度计。我们相信这一组合 7兆和60个脑电通道可以回答类似于 更大的阵列MEG系统。我们将使用和改进多个固定偶极子 脑磁图、EEG和ECoG在个体患者中的MR信息解决方案 为了改进模型估计，一个具有以下测量的EEG 4壳模型 单个患者的电导率，基本的有限元模型， 指尾轮尾带的定位和自发性的定位 脑磁图和脑磁图同时显示的部分发作。我们将制作一份 多源时空结构的详细比较 更好地理解诱发反应和更少地理解诱发反应之间的建模 了解尖峰和抽搐。 我们不要求新设备。我们要求为维护提供资金 7通道系统的费用、首席调查员的工资和 一名技术专家，为建模顾问提供差旅和用品，包括 液氦。这里要求的资金是最低限度的必要资金 继续对磁场的物理解释进行系统研究 电场和头皮及大脑皮层电场的统计个数 患者非侵入性地描述大脑中动脉的时空结构 用于术前定位的医学难治性部分性癫痫。

We have completed 3/5ths of the goals of the grant, making progress in all 5 steps of the research. We will complete the major goals of the grant within the time awarded on the grant. The 7 channel magnetometer, shielded room, and PPI are working beyond expectations in the same fiducial coordinates for MEG, EEG, ECoG, and MR scans using PPI resolution of < 1mm, excellent signal-to-noise ratios for spontaneous spikes and seizures, and adequate spatial coverage of the special coplanar wide gradiometer hexagon to capture a phase reversal and null point of spontaneous seizures and spikes during simultaneous ECoG. We have studied a large number of events in more patients. We have determined that a comprehensive study of a each patient improves localization accuracy and comparisons and that larger patient sample size is necessary to test further hypotheses. We will extend research in each step of the 5 step approach. We propose to study a larger number of patients with complete studies of MEG, EEG, and ECoG for implanted dipoles, evoked responses, and spontaneous spikes and seizures in each patient. We want to investigate propagation patterns of spikes and seizures for more accurate quantification of epileptic areas, of potential importance for surgical treatment. We plan to compare 7 MEG + 60 EEG channels to 37 MEG + 60 EEG channels to determine the added value of a large array MEG system and an upgrade to first derivative gradiometers. We believe the combination of 7 MEG and 60 EEG channels can answer important questions similar to a larger array MEG system. We will use and improve multiple fixed dipole solutions in MEG, EEG, and ECoG with MR information in individual patients to improve model estimates, an EEG 4 shell model with measurements of conductivities in individual patients, a basic finite element model, localizations of digit rostrocaudal bands, and localizations of spontaneous partial seizures in simultaneous MEG+EEG and MEG+ECoG. We will make a detailed comparison of spatiotemporal structure from multiple source modeling between the better understood evoked response and the less understood spike and seizure. We request no new equipment. We request funding for maintenance costs for the 7 channel system, salary for the principal investigator and a technologist, travel for consultants on modeling, and supplies including liquid helium. The funds requested here are the minimum essential to continue systematic research of physical interpretation of the magnetic field and scalp and cortical electric field in a statistical number of patients to describe non-invasively the spatiotemporal structure of medically intractable partial seizures for presurgical localization.