MAGNETOENCEPHALOGRAPHY IN EPILEPSY

我们已经完成了赠款目标的三分之五， 研究的五个步骤。 我们将完成主要目标 在授予授予的时间内授予。 7频道 磁力计、屏蔽室和PPI的工作超出了预期， 使用PPI进行MEG、EEG、ECoG和MR扫描的基准坐标相同 分辨率<1mm，自发性的信噪比极佳 尖峰和癫痫发作，并有足够的空间覆盖的特殊平面 宽梯度计六边形，以捕获 自发性癫痫发作和同步ECoG期间的尖峰。 我们研究了 更多患者发生大量事件。 我们已经确定， 对每个患者的综合研究提高了定位精度， 比较和更大的患者样本量是必要的测试 进一步的假设。 我们将在5个步骤的每一个步骤中进行研究 approach. 我们建议研究更多的患者， 植入偶极子的MEG、EEG和ECoG研究，诱发反应， 每名患者都有自发的尖峰和癫痫发作。 我们想研究 传播模式的尖峰和癫痫发作，以更准确地 癫痫区域的量化，对于外科手术具有潜在的重要性 治疗 我们计划将7个MEG +60 EEG通道与37个MEG +60 EEG通道进行比较 通道，以确定大阵列MEG系统的附加值， 升级到一阶导数梯度仪。 我们认为， 7个MEG和60个EEG通道可以回答类似于 更大的阵列MEG系统。 我们将使用和改进多个固定偶极子 MEG、EEG和ECoG中的解决方案，以及个体患者的MR信息 为了改善模型估计，EEG 4壳模型具有以下测量： 个体患者的电导率，一个基本的有限元模型， 指喙尾带的定位，以及自发性 MEG + EEG和MEG + ECoG同步部分性发作。 我们会做一个 多源时空结构详细比较 更好地理解诱发反应和更少的 理解了扣球和癫痫 我们不需要新设备。 我们要求提供维修资金 7通道系统的费用，主要研究者的工资， 一名技术专家、建模顾问的差旅费和用品，包括 液态氦 这里要求的资金是最低限度的必要， 继续系统地研究地球磁场的物理解释， 场和头皮和皮层电场的统计数字， 患者描述非侵入性的时空结构， 用于术前定位的医学上难治性部分性癫痫发作。

We have completed 3/5ths of the goals of the grant, making progress in all 5 steps of the research. We will complete the major goals of the grant within the time awarded on the grant. The 7 channel magnetometer, shielded room, and PPI are working beyond expectations in the same fiducial coordinates for MEG, EEG, ECoG, and MR scans using PPI resolution of < 1mm, excellent signal-to-noise ratios for spontaneous spikes and seizures, and adequate spatial coverage of the special coplanar wide gradiometer hexagon to capture a phase reversal and null point of spontaneous seizures and spikes during simultaneous ECoG. We have studied a large number of events in more patients. We have determined that a comprehensive study of a each patient improves localization accuracy and comparisons and that larger patient sample size is necessary to test further hypotheses. We will extend research in each step of the 5 step approach. We propose to study a larger number of patients with complete studies of MEG, EEG, and ECoG for implanted dipoles, evoked responses, and spontaneous spikes and seizures in each patient. We want to investigate propagation patterns of spikes and seizures for more accurate quantification of epileptic areas, of potential importance for surgical treatment. We plan to compare 7 MEG + 60 EEG channels to 37 MEG + 60 EEG channels to determine the added value of a large array MEG system and an upgrade to first derivative gradiometers. We believe the combination of 7 MEG and 60 EEG channels can answer important questions similar to a larger array MEG system. We will use and improve multiple fixed dipole solutions in MEG, EEG, and ECoG with MR information in individual patients to improve model estimates, an EEG 4 shell model with measurements of conductivities in individual patients, a basic finite element model, localizations of digit rostrocaudal bands, and localizations of spontaneous partial seizures in simultaneous MEG+EEG and MEG+ECoG. We will make a detailed comparison of spatiotemporal structure from multiple source modeling between the better understood evoked response and the less understood spike and seizure. We request no new equipment. We request funding for maintenance costs for the 7 channel system, salary for the principal investigator and a technologist, travel for consultants on modeling, and supplies including liquid helium. The funds requested here are the minimum essential to continue systematic research of physical interpretation of the magnetic field and scalp and cortical electric field in a statistical number of patients to describe non-invasively the spatiotemporal structure of medically intractable partial seizures for presurgical localization.