MAGNETOENCEPHALOGRAPHY IN EPILEPSY

癫痫脑磁图检查

基本信息

项目摘要

During the first year of the grant with a new 7-channel magnetometer we have made substantial progress in all 5 steps of the proposed research. We plan to complete the goals of the original 3 year research proposal within the 2 years awarded on the grant. We have: (1) modeled forward and inverse dipole solutions in MEG, EEG, and cortical EEG (ECoG) with goodness of fit measures and residuals; (2) modeled multiple moving dipole solutions in MEG; (3) localized the central fissure close to hand area of primary sensory cortex in 4 patients on MEG, EEG, and ECoG with moving dipole solutions, with localization errors of 4 to 6mm, verified by cortical stimulations; (4) recorded deep spikes on MEG; (5) mapped simultaneous, spontaneous MEG and ECoG of human interictal spikes; (6) verified MEG seizure localization within 1-1.5 cm by subdural recordings; (7) mapped simultaneous, spontaneous MEG and EEG of human partial seizures with dipolar patterns; and (8) implemented a 48 channel recording system for simultaneous MEG, EEG, and ECoG recording. During the final second year of the grant, we will complete all steps, mapping and localizing the center interictal spikes and seizures in multichannel MEG, EEG, and ECoG. The temporary use of a magnetically shielded room has been essential to systematic completion of steps 4 and 5. In this renewal, we propose extension of the research to more accurate epileptic source identification in a magnetically shielded room. The severe magnetic noise which has developed in our unshielded hospital environment markedly limits the natural extension of research into promising areas, developed at Reed and proved capable of study. A multichannel magnetometer in a shielded environment is essential to the systematic study of the spatiotemporal structure of simultaneous MEG, EEG and cortical EEG of the spontaneous and averaged human interictal spike and seizure. In this renewal, we request funds for salary for essential personnel and for a magnetically shielded room which we have tested during the last 2 months and the essential nature of which is shown in the progress report. We want to continue systematic investigation of MEG, comparison of MEG and EEG, and integrated use of their complementary information to identify intracranial current sources in a large number of patients to achieve statistical numbers. Funds are requested for essential consulting collaboration with Dr. Terrance Darcey of Yale University School of Medicine, New Haven, Connecticut, in MEG, EEG, and ECoG modeling. We have already obtained: (1) 39% of required funds for new equipment and (2) 36% of required funds for personnel from other sources, and those are exhausted. The funds requested here are the minimum essential to continue systematic research of the magnetic field of the human epileptic focus in a statistical number of patients.
在拨款的第一年,有一个新的7频道 磁力计我们在所有5个步骤中都取得了实质性的进展 建议的研究。我们计划完成 在获奖的2年内提出原件3年的研究建议 格兰特。我们有:(1)模拟正、逆偶极子解 在脑磁图、脑电图仪和皮质脑电图仪(ECoG)中使用拟合优度测量 和残差;(2)在MEG中模拟多个运动偶极子解; (3)将中央裂定位于原发手部附近 4例有运动的脑磁图、EEG和ECoG患者的感觉皮质 偶极子解,定位误差为4至6 mm,已验证 皮层刺激;(4)脑磁图记录到深棘波;(5) 人发作间期的同步、自发脑磁图和皮层脑电图 棘波;(6)证实脑磁图在1-1.5厘米内的癫痫定位 硬膜下记录;(7)同步标测,自发脑磁图和 具有偶极模式的人类部分性发作的脑电;和(8) 实现了48通道同步脑磁图记录系统, EEG和ECoG记录。在第二年的最后一年 Grant,我们将完成所有步骤,映射和本地化 多通道脑磁图、脑电图仪和脑电图仪的中枢性发作间期棘波和癫痫发作 ECG。临时使用磁屏蔽的房间已经被 对系统地完成步骤4和5至关重要。在这方面 更新,我们建议将研究范围扩大到更准确 在磁屏蔽的房间里辨认癫痫病源。 在我们的非屏蔽设备中发展起来的严重的磁噪声 医院环境明显限制了自然延伸 研究有前景的领域,在里德开发并被证明有能力 在学习方面。屏蔽环境中的多道磁力仪 对时空的系统研究是必不可少的 脑磁图、脑电和大脑皮层脑电的同步结构 自发的和平均的人类发作间期棘波和癫痫。在……里面 这次续签,我们要求拨款支付基本人员的工资 对于一个磁屏蔽的房间,我们在 过去两个月,其基本性质显示在 进度报告。我们希望继续系统地调查 脑磁图、脑磁图与脑电图仪的比较及综合应用 用于识别颅内电流源的补充信息 在大量的患者中实现了统计数字。 申请资金用于与Dr进行必要的咨询协作。 纽黑文耶鲁大学医学院的特伦斯·达西, 康涅狄格州,在脑磁图,EEG和ECoG建模中。我们已经这么做了 获得:(1)新设备所需资金的39%;(2)36% 来自其他来源的人员的所需资金,这些是 筋疲力尽。这里要求的资金是最低限度的必要资金 继续对人体磁场进行系统研究 统计了癫痫灶中的患者数量。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

William W. Sutherling其他文献

William W. Sutherling的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('William W. Sutherling', 18)}}的其他基金

MAGNETOENCEPHALOGRAM IN EPILEPSY
癫痫脑磁图
  • 批准号:
    2263981
  • 财政年份:
    1993
  • 资助金额:
    $ 30.12万
  • 项目类别:
Magnetoencephalogram in Epilepsy
癫痫脑磁图
  • 批准号:
    6581741
  • 财政年份:
    1993
  • 资助金额:
    $ 30.12万
  • 项目类别:
Magnetoencephalogram in Epilepsy
癫痫脑磁图
  • 批准号:
    6472535
  • 财政年份:
    1993
  • 资助金额:
    $ 30.12万
  • 项目类别:
MAGNETOENCEPHALOGRAM IN EPILEPSY
癫痫脑磁图
  • 批准号:
    2263980
  • 财政年份:
    1993
  • 资助金额:
    $ 30.12万
  • 项目类别:
Magnetoencephalogram in Epilepsy
癫痫脑磁图
  • 批准号:
    6875704
  • 财政年份:
    1993
  • 资助金额:
    $ 30.12万
  • 项目类别:
Magnetoencephalogram in Epilepsy
癫痫脑磁图
  • 批准号:
    6624143
  • 财政年份:
    1993
  • 资助金额:
    $ 30.12万
  • 项目类别:
MAGNETOENCEPHALOGRAM IN EPILESPY
癫痫脑磁图
  • 批准号:
    2263979
  • 财政年份:
    1993
  • 资助金额:
    $ 30.12万
  • 项目类别:
Magnetoencephalogram in Epilepsy
癫痫脑磁图
  • 批准号:
    6724816
  • 财政年份:
    1993
  • 资助金额:
    $ 30.12万
  • 项目类别:
MAGNETOENCEPHALOGRAM IN EPILEPSY
癫痫脑磁图
  • 批准号:
    2677086
  • 财政年份:
    1993
  • 资助金额:
    $ 30.12万
  • 项目类别:
MAGNETOENCEPHALOGRAM IN EPILEPSY
癫痫脑磁图
  • 批准号:
    2379602
  • 财政年份:
    1993
  • 资助金额:
    $ 30.12万
  • 项目类别:
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了