MAGNETOENCEPHALOGRAPHY AND EVOKED POTENTIALS IN EPILEPSY

研究计划将由三项研究组成， 对方. 这项研究的目的是获得新的见解， 正常和异常脑功能的动力学机制 实施和关联下列措施： 脑磁图（MEG）、大脑感觉诱发电位和 正电子发射计算机断层扫描（PCT）。 脑磁图 (MEG)将与EEG同时研究两种局灶性癫痫 和全身性癫痫患者，看看MEG是否能更好地定位 比EEG更能确定癫痫发作的病灶， 暗示了全身性癫痫小发作的潜在发生器 的 将局灶性发作间期棘波的MEG和EEG相互比较 并与病理学、深部电极癫痫发作和PCT相关， 对那些患有医学难治性癫痫发作的患者进行评估， 在加州大学洛杉矶分校做癫痫手术 长潜伏期的时间成分 听觉诱发电位（T-复合波）将研究之前和之后 前颞叶切除术在同一癫痫手术组中， 以确定T复合体是在细胞内还是在细胞外生成的。 切除量。 T复合体将在相同的患者中进行研究， 上述患者在PCT上有局灶性颞叶代谢减退，以确定 发作间期低代谢区代表抑制降低的区域 或减少兴奋，因为同侧T复合体反应似乎是 主要是IPSP，而对侧T复合体似乎主要是EPSP。 上述本地化有重要的实际方面， 癫痫临床治疗的机制研究。

The Research Plan will be composed of three studies which will complement each other. The goal of the research is to gain new insights into the dynamic mechanisms of normal and abnormal cerebral function by the application and correlation of the following measures: magnetoencephalography (MEG), cerebral sensory evoked potentials and positron emission computed tomography (PCT). The magnetoencephalogram (MEG) will be studied simultaneously with the EEG in both focal epilepsy and generalized epilepsy patients to see if the MEG is better localizing than the EEG for focus of seizure onset and if the MEG current patterns suggest an underlying generator in generalized "petit mal" seizures. The MEG and EEG of the focal interictal spike will be compared with each other and correlated with pathology, depth electrode seizure onsets and PCT in those patients with medically refractory seizures being evaluated for epilepsy surgery at UCLA. The temporal component of the long-latency auditory evoked potential (T-Complex) will be studied before and after anterior temporal lobectomy in the same epilepsy surgery group as mentioned above to determine if the T-Complex is generated inside or outside the volume of resection. The T-Complex will be studied in the same patients as above who have focal temporal hypometabolism on PCT to determine if the interictal zones of hypometabolism represent areas of decreased inhibition or decresed excitation, since ipsilateral T-Complex response appears to be primarily IPSPs and contralateral T-Complex appears to be primarily EPSPs. There are important practical aspects of the above localization and investigation of mechanisms in clinical epilepsy treatment.