MAGNETOENCEPHALOGRAPHY IN EPILEPSY

癫痫脑磁图检查

• 批准号: 3401425
• 负责人: William W. Sutherling
• 金额: $ 6.57万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 1984
• 资助国家: 美国
• 起止时间: 1984-07-01 至 1988-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3401425
• 关键词: brain disorder diagnosis; brain electrical activity; brain mapping; computer simulation; congenital oral /facial /cranial defect; direct cortical response; electrodes; evoked potentials; human subject; human tissue; magnetic field; magnetoencephalography; mathematical model; partial seizure

The Reed Neuromagnetism Laboratory with a single channel magnetometer has: (1) mapped the MEG and EEG of a human partial seizure, (2) mapped simultaneous MEG and subdural electrode of the human epileptic interictal spike, (3) used different EEG triggers to separate different spike populations in the epileptic focus, (4) modeled the MEG forward solution of a known current dipole in a human cadaver head, and (5) participated in an active collaboration with Dr. Terance M. Darcey who has modeled a moving dipole to fit both the MEG and EEG of a tangentially oriented human interictal spike mapped at UCLA. Further studies are being performed on those patients who have very frequent interictal spikes. This is anticipated to be productive but markedly limited in numbers studied and in the completeness of the information obtained. We proposed a systematic series of studies designed to extend epileptic source identification from the ideal computer model to realistic situations of interictal spikes and the seizure itself. The limitation of a single channel magnetometer prevents the natural extension of research into promising areas which have been developed at Reed and proved capable of study in the human partial seizure and in simultaneous MEG and subdural electrode monitoring. We have gone as far as we can go with 1 channel and cannot go further with our present system. A multichannel neuromagnetometer is essential to the proposed studies of the spatiotemporal structure of the MEG and EEG of the human partial seizure and of the simultaneous MEG, EEG and intracranial subdural EEG of the human interictal spike focus. In this renewal, we request the funds for a 7-channel neuromagnetometer and the salary for personnel, both essential to continue the proposed investigation of the MEG, comparison of the MEG and EEG, and integrated use of their complementary information to identify intracranial electric current sources. Funds are requested for essential consulting collaboration with Dr. Terrance Darcey at Yale University School of Medicine, New Haven, Connecticut, to model the MEG and EEG and to develop new modeling procedures to analyze the human epileptic focus. We have obtained half the funds for the neuromagnetometer from other sources and those have been completely exhausted. The funds requested here are the minimum essential to continue the research.

采用单通道磁力计的芦德神经磁学实验室具有： (1)映射人类部分发作的脑电和脑电；(2)映射 人癫痫发作间期的脑磁图和硬膜下电极 脉冲，(3)使用不同的脑电触发来分离不同的脉冲 癫痫灶中的人群，(4)模拟了脑磁图正向解 已知的人类身体头部的电流偶极子，以及(5)参与了 与Terance M.Darcey博士积极合作，Terance M.Darcey博士为 偶极子能同时拟合切向人类的脑磁图和脑电波 加州大学洛杉矶分校的发作间期棘波图。正在对以下问题进行进一步的研究 那些有非常频繁的发作间期棘波的患者。这是 预期是多产的，但在研究和研究的数量上明显有限 所获得的信息的完整性。我们提出了一个系统化的 旨在扩大癫痫来源识别的一系列研究 发作间歇期棘波的真实情况的理想计算机模型 癫痫发作本身。 单通道磁力计的局限性阻止了自然的 将研究扩展到有希望的领域，这些领域已经在 Reed，并被证明能够研究人类部分癫痫发作和 脑磁图和硬膜下电极同步监测。我们已经走到了 我们可以用一个频道，而不能用我们目前的系统走得更远。一个 多通道神经磁强计对拟议的 人类部分性癫痫的脑磁图和脑电的时空结构 人的脑磁图、脑电波和硬脑膜下脑电的同步研究 发作间期的棘波病灶。在这次续订中，我们请求资金用于 7通道神经磁强计和人员工资，两者都是必不可少的 继续拟议的对MEG的调查，比较MEG和 脑电，并综合利用它们的互补信息来识别 颅内电流源。申请资金是为了必要的 与耶鲁大学学院的Terrance Darcey博士进行咨询合作 康涅狄格州纽黑文医学部，对脑磁图和脑电进行建模，并 开发新的建模程序来分析人类癫痫灶。我们 已经从其他来源获得了神经磁强计一半的资金 而这些都已经完全耗尽了。在此申请的资金是 继续研究的最低要求。