SYSTEM FOR INSTANTANEOUS AUTONOMIC FUNCTION

瞬时自主功能系统

• 批准号: 2714706
• 负责人: LID B WONG
• 金额: $ 10万
• 依托单位: BIOTECHPLEX CORPORATION
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-09-01 至 1999-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2714706
• 关键词: autonomic nervous system; biomedical equipment development; clinical biomedical equipment; dogs; electrocardiographic monitor; heart rate; mathematical model; method development; model design /development; neuromuscular function

DESCRIPTION: This is a Phase one proposal which responds to the SBIR need for the development of novel methods of monitoring autonomic nervous function, from established investigators at Univ. Ill, Chicago. In this phase 1 project, methods will be developed for a system for instantaneous autonomic function based upon time-frequency analysis of heart rate. A specific time-frequency algorithm will be developed to adapt the characteristics of the HRV time series data to derive 3 characteristic frequency dependent indices for HRV every 30 seconds, including a sympathetic index (SI) a parasympathetic index (PI) and a ratio index (SI/PI). The algorithm will be developed and rigorously validated in dogs (Phase 1) by manipulating sympathetic and parasympathetic nervous input in a novel animal preparation. In Phase 2, they intend to test the algorithm in humans, and develop a compact portable system. PROPOSED COMMERCIAL APPLICATION: NOT AVAILABLE

描述：这是响应SBIR需求的第一阶段提案 用于开发监测自主神经的新方法， 功能，从伊利诺伊大学，芝加哥既定的研究人员。在这 第一阶段项目，将制定一个系统， 基于心率的时频分析的自主功能。一 将开发特定的时间-频率算法，以适应 心率变异性时间序列数据的特征以推导出3个特征 心率变异性的频率依赖指数，每30秒，包括 交感神经指数（SI）、副交感神经指数（PI）和比率指数 (SI/PI）。该算法将在狗身上进行开发和严格验证 （阶段1）通过操纵交感神经和副交感神经输入， 一种新型动物制剂。在第二阶段，他们打算测试算法 并开发出一个紧凑的便携式系统。 拟议商业应用：不可用