FIBER OPTIC LASER DOPPLER SYSTEM FOR CILIARY MOTILITY

Lidon Technologies(LIDON)建议开发一种系统来测量人体气管、支气管以及副鼻窦中纤毛活动的两个基本参数，即纤毛搏动频率(CBF)和异时脉波周期(MWP)。光纤激光多普勒系统(FLODS)传感探头将通过光纤支气管镜的采样通道插入。通过整合新技术，利顿将生产出第一个商业上可用的系统，在体内进行这些测量。利登将承担推出3个版本的Folds系统所需的研发工作。Folds-1：一个体外系统，旨在实时收集培养细胞和天然上皮中的CBF和MWP数据。Folds-2：一种活体系统，设计用于实时测量小动物和大动物气管和支气管内直径为3 mm的CBF和MWP。Folds-3：一种活体系统，旨在实时测量人体上下呼吸道的CBF和MWP。FLODS是一项使能技术，将有助于定量评估细胞、组织、动物和人类的纤毛活动，用于毒理学研究、药理学研究、肺部药物发现以及临床诊断和治疗。拟议的商业应用：该系统将用于表现出粘液纤毛运输障碍的鼻部和肺部疾病。该系统还适用于评估大多数类型的生物运动、流体的速度流分布以及物理振动的远程测量。

LiDon Technologies (LiDon) proposes to develop a system to measure, in the human tracheal and bronchial airways as well as in the paranasal sinuses, two fundamental parameters of ciliary activity governing effective mucociliary transport, namely, ciliary beat frequency (CBF) and metachronal wave period (MWP). The Fiber Optics Laser Doppler System (FOLDS) sensing probe will be inserted through the sampling channel of a fiber optic bronchoscope. Through the incorporation of novel technologies LiDon will produce the first commercially available system to make these measurements in vivo. LiDon will undertake the R & D necessary to launch 3 versions of the FOLDS system. FOLDS -1: An in vitro system designed to make realtime data collection of CBF and MWP in cultures and in native epithelia. FOLDS -2: An in vivo system designed to make realtime measurements of CBF and MWP in the trachea and bronchial airways to 3 mm diameter in small and large animals. FOLDS -3: An in vivo system designed to make realtime measurements of CBF and MWP in the upper and lower human respiratory tract. The FOLDS, being an enabling technology, will facilitate the quantitative assessment of ciliary activity in cells, tissues, animals and humans for toxicological studies, pharmacology research, pulmonary drug discovery, and clinical diagnosis and therapeutic treatment. PROPOSED COMMERCIAL APPLICATION: This system will be used in nasal and lung diseases that exhibit impairment of mucociliary transport. The system is also applicable to assess most types of biological motilities, velocity flow profile of fluids and well as remote measurements of physical vibrations.