FIBER OPTIC LASER DOPPLER SYSTEM FOR CILIARY MOTILITY

用于纤毛运动的光纤激光多普勒系统

• 批准号: 6183370
• 负责人: LID B WONG
• 金额: $ 35.41万
• 依托单位: BIOTECHPLEX CORPORATION
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-04-15 至 2002-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6183370
• 关键词: biomedical equipment development; bronchoscopy; cilium /flagellum motility; clinical biomedical equipment; dogs; endoscopy; fiber optics; lasers; pulmonary respiration; respiratory airflow measurement; respiratory epithelium; respiratory function; trachea; ultrasound blood flow measurement

LiDon Technologies (LiDon) proposes to develop a system to measure, in the human tracheal and bronchial airways as well as in the paranasal sinuses, two fundamental parameters of ciliary activity governing effective mucociliary transport, namely, ciliary beat frequency (CBF) and metachronal wave period (MWP). The Fiber Optics Laser Doppler System (FOLDS) sensing probe will be inserted through the sampling channel of a fiber optic bronchoscope. Through the incorporation of novel technologies LiDon will produce the first commercially available system to make these measurements in vivo. LiDon will undertake the R & D necessary to launch 3 versions of the FOLDS system. FOLDS -1: An in vitro system designed to make realtime data collection of CBF and MWP in cultures and in native epithelia. FOLDS -2: An in vivo system designed to make realtime measurements of CBF and MWP in the trachea and bronchial airways to 3 mm diameter in small and large animals. FOLDS -3: An in vivo system designed to make realtime measurements of CBF and MWP in the upper and lower human respiratory tract. The FOLDS, being an enabling technology, will facilitate the quantitative assessment of ciliary activity in cells, tissues, animals and humans for toxicological studies, pharmacology research, pulmonary drug discovery, and clinical diagnosis and therapeutic treatment. PROPOSED COMMERCIAL APPLICATION: This system will be used in nasal and lung diseases that exhibit impairment of mucociliary transport. The system is also applicable to assess most types of biological motilities, velocity flow profile of fluids and well as remote measurements of physical vibrations.

Lidon Technologies（Lidon）提议开发一个系统，以在人类气管和支气管呼吸道以及在偏丽的鼻窦中进行测量，这是两个基本参数的基本参数，这些纤毛活性涉及有效的粘膜循环运输，不，NOMIALE，睫状频率（CBF频率（CBF）和Metachronal波浪周期）。光纤激光多普勒系统（折叠）传感探针将通过光纤支气管镜的采样通道插入。 Lidon通过合并新技术将生成第一个在体内进行这些测量的市售系统。 Lidon将进行启动3个版本的Folds系统所需的研发。折叠-1：一种体外系统，旨在在培养物和天然上皮中进行CBF和MWP的实时数据收集。折叠-2：一种体内系统，旨在在小动物和大型动物的气管和支气管气道中对CBF和MWP进行实时测量。折叠-3：一种体内系统，旨在在人类呼吸道上进行实时测量CBF和MWP的实时测量。这些折叠是一种有利的技术，将促进细胞，组织，动物和人类纤毛活性的定量评估，用于毒理学研究，药理学研究，肺部药物发现以及临床诊断和治疗治疗。拟议的商业应用：该系统将用于鼻和肺部疾病，这些疾病表现出损伤的粘毛转运。该系统还适用于评估大多数类型的生物学运动，流体的速度流量以及物理振动的远程测量。