FIBER OPTIC LASER DOPPLER SYSTEM FOR CILIARY MOTILITY

LiDon Technologies（LiDon）提出开发一种系统来在人气管和支气管气道以及鼻旁窦中测量支配有效粘膜纤毛运输的纤毛活动的两个基本参数，即纤毛搏动频率（CBF）和异时波周期（MWP）。光纤激光多普勒系统（FOLDS）传感探头将通过光纤支气管镜的采样通道插入。通过结合新技术，LiDon将生产第一个商业化的系统，在体内进行这些测量。LiDon将进行必要的研发，以推出3个版本的FOLDS系统。FOLDS-1：设计用于实时收集培养物和天然上皮细胞中CBF和MWP数据的体外系统。折叠-2：设计用于实时测量小型和大型动物气管和支气管气道中直径为3 mm的CBF和MWP的体内系统。FOLDS-3：设计用于实时测量人体上下呼吸道中CBF和MWP的体内系统。FOLDS作为一种使能技术，将有助于定量评估细胞、组织、动物和人体中的纤毛活性，用于毒理学研究、药理学研究、肺部药物发现以及临床诊断和治疗。拟议的商业应用：该系统将用于粘液纤毛运输受损的鼻和肺部疾病。该系统还适用于评估大多数类型的生物运动性、流体的速度流剖面以及物理振动的远程测量。

LiDon Technologies (LiDon) proposes to develop a system to measure, in the human tracheal and bronchial airways as well as in the paranasal sinuses, two fundamental parameters of ciliary activity governing effective mucociliary transport, namely, ciliary beat frequency (CBF) and metachronal wave period (MWP). The Fiber Optics Laser Doppler System (FOLDS) sensing probe will be inserted through the sampling channel of a fiber optic bronchoscope. Through the incorporation of novel technologies LiDon will produce the first commercially available system to make these measurements in vivo. LiDon will undertake the R & D necessary to launch 3 versions of the FOLDS system. FOLDS -1: An in vitro system designed to make realtime data collection of CBF and MWP in cultures and in native epithelia. FOLDS -2: An in vivo system designed to make realtime measurements of CBF and MWP in the trachea and bronchial airways to 3 mm diameter in small and large animals. FOLDS -3: An in vivo system designed to make realtime measurements of CBF and MWP in the upper and lower human respiratory tract. The FOLDS, being an enabling technology, will facilitate the quantitative assessment of ciliary activity in cells, tissues, animals and humans for toxicological studies, pharmacology research, pulmonary drug discovery, and clinical diagnosis and therapeutic treatment. PROPOSED COMMERCIAL APPLICATION: This system will be used in nasal and lung diseases that exhibit impairment of mucociliary transport. The system is also applicable to assess most types of biological motilities, velocity flow profile of fluids and well as remote measurements of physical vibrations.