CONCENTRATED AEROSOL DELIVERY AND QUANTIZATION SYSTEM

浓缩气溶胶输送和量化系统

• 批准号: 2867638
• 负责人: LID B WONG
• 金额: $ 10万
• 依托单位: BIOTECHPLEX CORPORATION
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-06-01 至 2000-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2867638
• 关键词: aerosols; biomedical equipment development; drug delivery systems; fluoresceins; inhalation drug administration; laboratory rat; measurement; physical property; plethysmography; spectrometry

LiDon Technologies proposes to develop an improved aerosol delivery system. The proposed system, Concentrated Aerosol Delivery and Quantization System, CADAQS, will fulfill the need to acutely deliver high particle number concentrations of aerosols to small animals (rats, young rabbits, and guinea pigs: wt < 1000 g), while enabling the regional quantization of their deposition in the lungs. The CADAQS consists of 3 subsystems. A) A two stage aerosol concentrator, TSAC, concentrates aerosols of 1-5 mu m AMMD from 10 to 100 times. B) A small Animal Aerosol Delivery System, SAADS. C) A Quantitative Aerosol Deposition System, QADS. In this Phase I project, we will focus on the construction and testing the two stage TSAC. Following the optimization of the parameters of the TSAC, the particle size (mass median aerodynamic diameter) and the concentration factors will be determined for both aqueous and solid aerosols using a Marble-Miller cascade impactor. The aqueous aerosols, generated from fluorescein solution, will be determined spectrophotometrically. The solid aerosols, generated from radiotagged iron oxide sol, will be determined by a V-nuclear technique. In Phase II, the TSAC system will be integrated with the SAADS and QADS. This CADAQS system will then be tested using rats. The TSAC, the SAADS, and the QADS are designed to be sold as stand-alone devices as well as components of CADAQS. Such a system is not available commercially. LiDon believes this system will greatly facilitate and enhance the processes of drug discovery, respiratory toxicology and pharmacology through the delivery of drugs to the respiratory tract for both local and systemic drug delivery. PROPOSED COMMERCIAL APPLICATIONS: This system is used to deliver concentrated aerosols to the respiratory tract of small animals while enabling the regional quantization of the deposited aerosol. This system can also act as a forerunner for the development of technologies for measuring cardiopulmonary function and aerosol deliveries to premature infants.

LiDon Technologies提出开发一种改进的气溶胶输送系统。所提出的系统，浓缩气溶胶输送和量化系统，CADAQS，将满足急性输送高颗粒数浓度的气溶胶到小动物（大鼠，幼兔和豚鼠：体重< 1000 g）的需要，同时使其在肺部的沉积区域量化。CADAQ由3个子系统组成。A）两级气溶胶浓缩器TSAC将1-5 μ m AMMD的气溶胶浓缩10至100倍。B）小动物气溶胶递送系统，SAADS。C）定量气溶胶沉积系统，QADS。在第一期工程中，我们将重点建设和测试两个阶段的TSAC。在优化TSAC的参数后，将使用Marble-Miller级联撞击采样器测定含水和固体气溶胶的粒度（质量中值空气动力学直径）和浓度因子。荧光素溶液产生的水性气溶胶将通过荧光光度法测定。由放射性标记的氧化铁溶胶产生的固体气溶胶将由V核技术确定。在第二阶段，TSAC系统将与SAADS和QADS集成。然后将使用大鼠对该CADAQ系统进行测试。TSAC、SAADS和QADS设计为作为独立设备以及CADAQ组件销售。这样的系统在商业上是不可得的。LiDon认为，通过将药物输送到呼吸道进行局部和全身药物输送，该系统将极大地促进和增强药物发现，呼吸毒理学和药理学的过程。拟议的商业应用：该系统用于将浓缩气溶胶输送到小动物的呼吸道，同时能够对沉积的气溶胶进行区域量化。该系统还可以作为测量早产儿心肺功能和气雾剂输送技术发展的先驱。