CONCENTRATED AEROSOL DELIVERY AND QUANTIZATION SYSTEM

浓缩气溶胶输送和量化系统

• 批准号: 2867638
• 负责人: LID B WONG
• 金额: $ 10万
• 依托单位: BIOTECHPLEX CORPORATION
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-06-01 至 2000-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2867638
• 关键词: aerosols; biomedical equipment development; drug delivery systems; fluoresceins; inhalation drug administration; laboratory rat; measurement; physical property; plethysmography; spectrometry

LiDon Technologies proposes to develop an improved aerosol delivery system. The proposed system, Concentrated Aerosol Delivery and Quantization System, CADAQS, will fulfill the need to acutely deliver high particle number concentrations of aerosols to small animals (rats, young rabbits, and guinea pigs: wt < 1000 g), while enabling the regional quantization of their deposition in the lungs. The CADAQS consists of 3 subsystems. A) A two stage aerosol concentrator, TSAC, concentrates aerosols of 1-5 mu m AMMD from 10 to 100 times. B) A small Animal Aerosol Delivery System, SAADS. C) A Quantitative Aerosol Deposition System, QADS. In this Phase I project, we will focus on the construction and testing the two stage TSAC. Following the optimization of the parameters of the TSAC, the particle size (mass median aerodynamic diameter) and the concentration factors will be determined for both aqueous and solid aerosols using a Marble-Miller cascade impactor. The aqueous aerosols, generated from fluorescein solution, will be determined spectrophotometrically. The solid aerosols, generated from radiotagged iron oxide sol, will be determined by a V-nuclear technique. In Phase II, the TSAC system will be integrated with the SAADS and QADS. This CADAQS system will then be tested using rats. The TSAC, the SAADS, and the QADS are designed to be sold as stand-alone devices as well as components of CADAQS. Such a system is not available commercially. LiDon believes this system will greatly facilitate and enhance the processes of drug discovery, respiratory toxicology and pharmacology through the delivery of drugs to the respiratory tract for both local and systemic drug delivery. PROPOSED COMMERCIAL APPLICATIONS: This system is used to deliver concentrated aerosols to the respiratory tract of small animals while enabling the regional quantization of the deposited aerosol. This system can also act as a forerunner for the development of technologies for measuring cardiopulmonary function and aerosol deliveries to premature infants.

Lidon Technologies建议开发改进的气溶胶输送系统。提出的系统，集中的气溶胶输送和量化系统CADAQS将满足急性向小动物（大鼠，年轻的兔子和豚鼠：WT <1000 g）急性递送高颗粒浓度的气溶胶浓度，同时实现其在肺中的区域量化的同时。 CADAQ由3个子系统组成。 a）两级气溶胶浓缩剂TSAC浓缩1-5 mu m ammd的气溶胶从10到100倍。 b）一个小型动物气溶胶输送系统，萨德。 C）定量气溶胶沉积系统，QADS。在这个阶段的项目中，我们将重点关注构建和测试两个阶段的TSAC。在优化TSAC的参数之后，将使用大理石 - 磨砂器级联撞击器确定颗粒尺寸（质量中位空气动力学直径）和浓度因子。由荧光素溶液产生的水溶胶将通过分光光度测定。由氧化铁溶胶产生的固体气溶胶将由V-核技术确定。在第二阶段，TSAC系统将与SAADS和QADS集成。然后将使用大鼠测试此CADAQS系统。 TSAC，SAADS和QADS的设计目的是作为独立设备以及CADAQS的组件出售。这样的系统在商业上不可用。利登认为，该系统将通过将药物递送到呼吸道上，以促进和增强药物发现，呼吸毒理学和药理学的过程，以供局部和全身药物递送。拟议的商业应用：该系统用于向小动物的呼吸道传递浓缩气溶胶，同时实现沉积气溶胶的区域量化。该系统还可以充当开发用于测量心肺功能和向早产儿的气溶胶传递技术的技术的先驱。