CONCENTRATED AEROSOL DELIVERY AND QUANTIZATION SYSTEM

浓缩气溶胶输送和量化系统

• 批准号: 2867638
• 负责人: LID B WONG
• 金额: $ 10万
• 依托单位: BIOTECHPLEX CORPORATION
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-06-01 至 2000-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2867638
• 关键词: aerosols; biomedical equipment development; drug delivery systems; fluoresceins; inhalation drug administration; laboratory rat; measurement; physical property; plethysmography; spectrometry

LiDon Technologies proposes to develop an improved aerosol delivery system. The proposed system, Concentrated Aerosol Delivery and Quantization System, CADAQS, will fulfill the need to acutely deliver high particle number concentrations of aerosols to small animals (rats, young rabbits, and guinea pigs: wt < 1000 g), while enabling the regional quantization of their deposition in the lungs. The CADAQS consists of 3 subsystems. A) A two stage aerosol concentrator, TSAC, concentrates aerosols of 1-5 mu m AMMD from 10 to 100 times. B) A small Animal Aerosol Delivery System, SAADS. C) A Quantitative Aerosol Deposition System, QADS. In this Phase I project, we will focus on the construction and testing the two stage TSAC. Following the optimization of the parameters of the TSAC, the particle size (mass median aerodynamic diameter) and the concentration factors will be determined for both aqueous and solid aerosols using a Marble-Miller cascade impactor. The aqueous aerosols, generated from fluorescein solution, will be determined spectrophotometrically. The solid aerosols, generated from radiotagged iron oxide sol, will be determined by a V-nuclear technique. In Phase II, the TSAC system will be integrated with the SAADS and QADS. This CADAQS system will then be tested using rats. The TSAC, the SAADS, and the QADS are designed to be sold as stand-alone devices as well as components of CADAQS. Such a system is not available commercially. LiDon believes this system will greatly facilitate and enhance the processes of drug discovery, respiratory toxicology and pharmacology through the delivery of drugs to the respiratory tract for both local and systemic drug delivery. PROPOSED COMMERCIAL APPLICATIONS: This system is used to deliver concentrated aerosols to the respiratory tract of small animals while enabling the regional quantization of the deposited aerosol. This system can also act as a forerunner for the development of technologies for measuring cardiopulmonary function and aerosol deliveries to premature infants.

LiDon科技公司建议开发一种改进的气溶胶输送系统。拟议的系统，浓缩气溶胶输送和量化系统，CADAQS，将满足向小动物（大鼠，幼兔和豚鼠：wt < 1000 g）急性输送高颗粒数浓度气溶胶的需求，同时能够对其在肺部的沉积进行区域量化。CADAQS系统由3个子系统组成。A)二级气溶胶浓缩器TSAC，可将1-5 μ m AMMD的气溶胶浓缩10 - 100次。B)小型动物气溶胶输送系统（SAADS）。C)定量气溶胶沉积系统。在第一期工程中，我们将重点建设和测试两阶段的TSAC。在优化TSAC参数之后，将使用大理石-米勒级联撞击器确定水溶胶和固体气溶胶的粒径（质量中值气动直径）和浓度因子。荧光素溶液产生的水溶胶将用分光光度法测定。由放射性标记氧化铁溶胶产生的固体气溶胶将由v -核技术测定。在第二阶段，TSAC系统将与SAADS和QADS集成。这个CADAQS系统将在大鼠身上进行测试。TSAC， SAADS和QADS被设计为作为独立设备以及CADAQS的组件出售。这种系统在商业上是不可用的。LiDon相信该系统将极大地促进和加强药物发现、呼吸毒理学和药理学的过程，通过将药物输送到呼吸道进行局部和全身给药。拟议的商业应用：该系统用于将浓缩气溶胶输送到小动物的呼吸道，同时使沉积的气溶胶能够进行区域量化。该系统也可以作为一个先导技术的发展，测量心肺功能和气溶胶输送给早产儿。