CONCENTRATED AEROSOL DELIVERY AND QUANTIZATION SYSTEM

LiDon Technologies 提议开发一种改进的气雾剂输送系统。所提出的系统，即浓缩气溶胶输送和量化系统，CADAQS，将满足向小动物（大鼠、幼兔和豚鼠：重量< 1000 g）快速输送高颗粒数浓度气溶胶的需求，同时能够对其在肺部的沉积进行区域量化。 CADAQS 由 3 个子系统组成。 A) 两级气溶胶浓缩器 TSAC，将 1-5 μm AMMD 的气溶胶浓缩 10 至 100 倍。 B) 小型动物气雾剂输送系统，SAADS。 C) 定量气溶胶沉积系统，QADS。在本期项目中，我们将重点关注两阶段TSAC的建设和测试。优化 TSAC 参数后，将使用 Marble-Miller 级联冲击器确定水性和固体气溶胶的粒径（质量中值空气动力学直径）和浓缩因子。由荧光素溶液产生的水性气溶胶将通过分光光度法测定。由放射性标记的氧化铁溶胶产生的固体气溶胶将通过 V 核技术进行测定。在第二阶段，TSAC系统将与SAADS和QADS集成。然后，该 CADAQS 系统将使用大鼠进行测试。 TSAC、SAADS 和 QADS 旨在作为独立设备以及 CADAQS 的组件进行销售。这样的系统无法在商业上获得。 LiDon 相信，该系统将通过将药物输送到呼吸道进行局部和全身给药，从而极大地促进和增强药物发现、呼吸毒理学和药理学的过程。拟议的商业应用：该系统用于将浓缩气溶胶输送到小动物的呼吸道，同时实现沉积气溶胶的区域量化。该系统还可以成为测量心肺功能和早产儿气雾输送技术开发的先驱。

LiDon Technologies proposes to develop an improved aerosol delivery system. The proposed system, Concentrated Aerosol Delivery and Quantization System, CADAQS, will fulfill the need to acutely deliver high particle number concentrations of aerosols to small animals (rats, young rabbits, and guinea pigs: wt < 1000 g), while enabling the regional quantization of their deposition in the lungs. The CADAQS consists of 3 subsystems. A) A two stage aerosol concentrator, TSAC, concentrates aerosols of 1-5 mu m AMMD from 10 to 100 times. B) A small Animal Aerosol Delivery System, SAADS. C) A Quantitative Aerosol Deposition System, QADS. In this Phase I project, we will focus on the construction and testing the two stage TSAC. Following the optimization of the parameters of the TSAC, the particle size (mass median aerodynamic diameter) and the concentration factors will be determined for both aqueous and solid aerosols using a Marble-Miller cascade impactor. The aqueous aerosols, generated from fluorescein solution, will be determined spectrophotometrically. The solid aerosols, generated from radiotagged iron oxide sol, will be determined by a V-nuclear technique. In Phase II, the TSAC system will be integrated with the SAADS and QADS. This CADAQS system will then be tested using rats. The TSAC, the SAADS, and the QADS are designed to be sold as stand-alone devices as well as components of CADAQS. Such a system is not available commercially. LiDon believes this system will greatly facilitate and enhance the processes of drug discovery, respiratory toxicology and pharmacology through the delivery of drugs to the respiratory tract for both local and systemic drug delivery. PROPOSED COMMERCIAL APPLICATIONS: This system is used to deliver concentrated aerosols to the respiratory tract of small animals while enabling the regional quantization of the deposited aerosol. This system can also act as a forerunner for the development of technologies for measuring cardiopulmonary function and aerosol deliveries to premature infants.