BEHAVIORAL AND HORMONAL RESPONSES TO STRESS IN CHILDREN

儿童对压力的行为和荷尔蒙反应

• 批准号: 2674346
• 负责人: Megan R Gunnar
• 金额: $ 10.29万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-09-01 至 2001-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2674346
• 关键词: behavioral /social science research tag; child behavior; child psychology; clinical research; coping; cortisol; human subject; infant human (0-1 year); interleukin 1; longitudinal human study; mucosal immunity; neuroendocrine system; physiologic stressor; preschool child (1-5); psychological stressor; psychoneuroimmunology; stress

DESCRIPTION (Adapted from applicant's abstract): This is an application for a 2nd NIMH K02 award. The applicant's research has dealt with the psychobiology of stress in young children, emphasizing activity of the hypothalamic-pituitary-adrenocortical (HPA) system an adequate understanding of the psychobiology of stress in childhood, however, requires integration of our rich understanding of psychosocial processes in human development, with our emerging understanding of multiple stress-sensitive physiological systems. Much of the first K02 period has been spend developing collaborative relations and beginning expertise that has allowed me to obtain funding for a 5-year period to test an integrative (temperament-coping resources-stress) psychobiologic model of stress in childhood. According to this model, a "stress reactive" temperament (the biological components of which are assessed through baseline EEG asymmetry, vagal tone, basal HPA activity, and positive late components of the ERP) influences the child's likelihood of perceiving events as potentially threatening. However, activation of physiological stress reactions (cardiac, HPA, and immune) are presumed to follow from expectations that the threat will be realized. Mediating these reactions are the coping resources (person and situation factors) available to the child. The proposed studies are designed to integrate 3 major literatures: (1) the physiology of infant/child temperament, (2) socioemotional development, including attachment research, and (3) psychobiologic studies of infant/child stress. This Career Plan emphasizes the need to extend this research to the study of child health (e.g. stress-immune functioning-infectious disease) issues in pediatric research (i.e., pain regulation, colic), high risk populations (i.e., maltreated children, early deprivation(, and to include other systems important in the regulation of stress (i.e., sleep as a process variable). Preliminary work, collaborative relations (with T. Boyce, R. Barr, R. Dahl, S. Suomi, M. Carlson, D. Cicchetti), and pilot data are described to support need for release time to enhance training and research into these related areas. The Institute of Child Development and the University of Minnesota provide rich resources for the candidate's career development. The institute is fully committed to this award as evidenced in the last K02 period. The candidate's would continue to be able to commit 80 percent time to research, with a minimal teaching load and additional support for travel and the development of collaborations within and without the university.

描述（改编自申请人的摘要）：这是一个应用程序， 第二届NIMH K 02奖 申请人的研究涉及 心理生物学的压力，在幼儿，强调活动的 下丘脑-垂体-肾上腺皮质（HPA）系统的充分了解 然而，童年压力的心理生物学需要整合 我们对人类发展中心理社会过程的丰富理解， 随着我们对多种压力敏感生理学的理解的不断加深， 系统. 第一个K 02时期的大部分时间都花在了开发 合作关系和开始的专业知识，使我能够 获得为期5年的资金，以测试一个综合的 （气质-应对资源-压力）心理生物学模型 童年. 根据这个模型，一个“压力反应”的气质（ 其生物成分通过基线EEG不对称性进行评估， 迷走神经张力、基础HPA活性和ERP的阳性晚期成分） 会影响孩子感知事件的可能性， 威胁。 然而，生理应激反应的激活 （心脏，HPA和免疫）被假定为遵循预期， 威胁将会实现。 调节这些反应的是应对资源 （个人和情况因素）。 拟议的研究 本文旨在综合3个主要文献：（1） 婴儿/儿童气质，（2）社会情感发展，包括 依恋研究;（3）婴幼儿应激的心理生物学研究。 本职业计划强调，需要将这项研究扩展到以下方面的研究： 儿童健康（如压力-免疫功能-传染病）问题 儿科研究（即，疼痛调节，绞痛），高危人群 (i.e.,虐待儿童、早期剥夺（以及包括其他制度） 在压力调节中很重要（即，睡眠作为一个过程变量）。 前期工作，合作关系（与T。博伊斯河巴尔河达尔 S. Suomi，M.卡尔森，D。Cicchetti），并描述了试点数据，以支持 需要释放时间，以加强培训和研究这些相关的 地区 儿童发展研究所和明尼苏达大学 为候选人的职业发展提供丰富的资源。 的 研究所完全致力于这一奖项，这在过去的K 02证明 期 候选人将继续能够投入80%的时间 研究，以最小的教学负担和额外的旅行支持 以及大学内外合作的发展。