THALAMIC CHANGES IN SCHIZOPHRENIA--A MORPHOMETRIC STUDY

精神分裂症的丘脑变化——形态学研究

• 批准号: 2675515
• 负责人: WILLIAM M BYNE
• 金额: $ 7.62万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-04-01 至 2000-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2675515
• 关键词: cellular pathology; histology; human tissue; postmortem; schizophrenia; thalamus

DESCRIPTION (Adapted from applicant's abstract): A number of recent studies have found a schizophrenia-associated loss of cells or volume in the human thalamus. Unfortunately, these previous studies did not have the resolution necessary to precisely localize the abnormalities. The specific aims of the proposed research are to use efficient stereological methods to: 1) Survey the entire thalamus for schizophrenia-related loss of volume or cellularity, 2) Localize any detected abnormalities to particular cytoarchitectonic divisions, and 3) Investigate the specificity of any detected abnormalities to schizophrenia. The investigator will use well-characterized postmortem material from the Mount Sinai Medical Center/Bronx Veteran's Affairs Hospital Schizophrenia Brain Bank to test the following primary hypotheses: 1) Previously reported schizophrenia-associated abnormalities in the mediodorsal thalamic nucleus will primarily involve its parvocellular and caudal divisions which, in man, have a prefrontal cortical dependence. The magnocellular division which does not degenerate following prefrontal ablations may be relatively spared in schizophrenia. 2) Schizophrenia-associated loss of cells and volume will not be restricted to the mediodorsal nucleus. Other nuclei where abnormalities are likely to occur include those with predominately temporolimbic connections and those with patterns of connections suggesting the potential for a role in arousal or in gating signals to and from cortex. The more specific sensory and motor relay nuclei are likely to be spared. 3) The schizophrenia-associated thalamic abnormalities are not common to all chronic mental illnesses and will not be seen in subjects with affective disorders. The studies of the present proposal will lay the groundwork for more definitive future explorations that will more fully assess the main and interactive effects of age, chronic institutionalization, neuroleptic exposure, and gender on the anatomy of thalamic nuclei where schizophrenia-associated abnormalities are found.

描述（改编自申请人摘要）：一些近期研究 已经在人类中发现了与精神分裂症相关的细胞或体积损失， 丘脑 不幸的是，这些以前的研究没有解决 精确定位异常所必需的。 该委员会的具体目标 建议的研究是使用有效的体视学方法：1）调查 整个丘脑的精神分裂症相关的体积或细胞的损失， 2)将任何检测到的异常定位于特定的细胞结构 3）调查任何检测到的异常的特异性 精神分裂症 研究人员将使用充分表征的尸检 西奈山医疗中心/布朗克斯退伍军人事务部的材料 医院精神分裂症脑库测试以下主要假设： 1)先前报道的精神分裂症相关异常， 丘脑背内侧核将主要涉及其小细胞和 在人类中，这些区域依赖于前额叶皮层。 的 大细胞分裂在前额叶后不退化 在精神分裂症中消融可能相对较少。 （二） 精神分裂症相关的细胞和体积损失将不限于 内侧背核 其他核团的异常可能 包括那些以颞缘连接为主的人和那些 连接的模式暗示了在唤醒中的潜在作用 或者控制大脑皮层的信号 更具体的感官和 运动中继细胞核可能会幸免。 3)精神分裂症相关的 丘脑异常并不常见于所有慢性精神疾病， 在情感性精神障碍患者中是看不到的。 的这两份研究报告 目前的建议将为更明确的未来奠定基础。 探索，将更充分地评估的主要和相互作用的影响， 年龄、长期机构化、精神抑制剂暴露和性别对 丘脑核的解剖，其中精神分裂症相关的异常是 found.