HORMONES IN CAUSE AND TREATMENT OF AFFECTIVE DISORDERS

在实验室里，工作将针对三个内源 神经肽、催产素、神经降压素和促甲状腺激素释放 激素(TRH)。与Oxy合作将重点放在这种多肽的性质上 在处女雌性大鼠身上产生母性行为。现在人们的兴趣集中在 关于阻断内源性Oxy在触发这一行为中的作用 情况多种多样。神经降压素之所以令人感兴趣是因为它的许多 其作用与抗精神病药物的作用平行。我们建议确定 NT延长戊巴比妥钠诱导睡眠时间的脑内部位 它还能增强戊巴比妥诱导的体温过低。其他内容 研究涉及NT在体温调节中的作用。当NT延长时 戊巴比妥诱导的睡眠时间，TRH缩短。我们将使用这个 TRH的性质研究可能的TRH合成抑制剂的作用 和TRH降解的抑制剂。其他研究针对的是 TRH和NT之间可能存在相互作用。 在临床上，工作重点将集中在三个内源性多肽：NT、TRH和 胰岛素。因为NT可以钝化TSH对TRH的反应，它将是 有兴趣辨别反应迟钝的患者是否发生了变化 脊髓液中NT的水平。TSH对TRH的反应也将被研究。 关于它在大量正常人群中的特征和它的 可能受月经周期阶段的影响。它在以下方面可能的价值 L-三碘甲腺原氨酸作为丙咪嗪辅助药的疗效预测 在抑郁症方面也将进行研究。行为和内分泌效应 将在正常人和精神分裂症患者身上进行胰岛素的研究 而低血糖是通过注射葡萄糖来预防的。这些研究 部分原因是最近的观察表明，并不是所有的内分泌影响 大量的胰岛素是由低血糖引起的。 这个对行为和预测性的广泛研究计划 动物和人类体内的多肽荷尔蒙的特性将涉及一个 各种技术和大量熟练掌握技术的合作者 特殊用途。

In the laboratory, work will be addressed to three endogenous neuropeptides, oxytocin (OXY), neurotensin (NT) and thyrotropin-releasing hormone (TRH). Work with OXY will focus on the property of this peptide to produce maternal behavior in virgin female rats. Interest is now focused on blocking the action of endogenous OXY in triggering this behavior in a variety of circumstances. Neurotensin is of interest because many of its actions run parallel to those of neuroleptic drugs. We propose to identify the sites in brain where NT enhances pentobarbital-induced sleeping time and where it enhances pentobarbital-induced hypothermia. Additional studies bear upon the role of NT in thermoregulation. While NT prolongs pentobarbital-induced sleeping time, TRH shortens it. We will use this property of TRH to study the action of putative inhibitors of TRH synthesis and inhibitors of TRH degradation. Additional studies are addressed to probable interactions between TRH and NT. In the clinic, work will focus on three endogenous peptides: NT, TRH, and insulin. Because NT can blunt the TSH response to TRH it will be of interest to discern whether patients with blunted responses have altered levels of NT in spinal fluid. The TSH response to TRH will also be studied as regards its characteristics in a large population of normals and its possible influence by stage of the menstrual cycle. Its possible value in predicting the efficacy of L-triiodothyronine as an adjunct to imipramine in depression will also be studied. The behavioral and endocrine effects of insulin will be studied in normal subjects and schizophrenic patients while hypoglycemia is prevented by glucose administration. These studies are prompted in part by recent observations that not all endocrine effects of insulin are due to hypoglycemia. This broad program of research into the behavioral and predictive properties of peptide hormones in both animals and man will involve a variety of techniques and a number of collaborators skilled in their special application.