MHCRC - PSYCHOENDOCRINOLOGY: CHILDREN AND ADULTS

此申请寻求NIMH CRC的持续支持 致力于研究成年人的主要精神障碍， 孩子 在成年人中，这些包括抑郁症，躁狂症，酗酒， 惊恐障碍和精神分裂症;在儿童（或年轻人）中， 闭合性头部损伤的后遗症 的理论基础 拟议的研究主要包括以下原则： 神经内分泌学和精神内分泌学;还采用了 神经递质生理学原理，药效学 动力学，免疫学，神经心理学，生物统计学，生命 历史和计算机科学。 两个内分泌缺陷--TSH对TRH的反应降低， 地塞米松后皮质醇抑制失败--提供病灶 组织几项拟议的临床研究。 其他 概念主题是：精神分裂症患者的神经安定剂代谢 患者;抑郁和躁狂患者对药物的反应， 改变胆碱能功能;情感性5-羟色胺功能 紊乱 两项研究探索了全新的领域： 低血糖是胰岛素行为效应所必需的; 考虑到诱人的生物化学关系， 利血平和TRH对行为和内分泌的影响 功能？ 一项流行病学设计的研究， 在表现上领先于其他人，评估发病率， 边缘性甲状腺功能减退症在精神科中意义 住院病人 精神兴奋剂对晚期脑梗死患者的影响 还将研究闭合性头部损伤的后果。 该中心的四个基础科学部分（一个是新的）是并列的 五个临床科室（两个 新的）。 几项研究集中在HPT轴上： 肽生理学的重要性一般来说，TRH 合成; TRH和胆碱能系统如何相互作用， 抑郁模型（Porsolt测试）;即使轻微 甲状腺功能减退增加大鼠ECT后记忆丧失？ 一些 动物研究探索了肽作为 肾上腺素能或胆碱能活性和早期效应 分离后的HPT和HPA功能。 其他研究 与我们对精神分裂症的兴趣产生共鸣： 在生殖周期中的DA代谢; 性腺类固醇对DA能活性的影响;糖尿病对 DA受体功能。 六个核心小组（三个是新的）支持临床和基础 科学部门，并加强彼此的工作。 教学和 该中心的培训活动也随着 研究活动的深度和广度。

This application seeks continuation support for a NIMH CRC dedicated to the study of major mental disorders of adults and children. In adults these include depression, mania, alcoholism, panic disorder and schizophrenia; in children (or young adults), the sequelae of closed head injury. The theoretical base for the proposed studies consists largely of the principles of neuroendocrinology and psychoendocrinology; also employed are the principles of neurotransmitter physiology, pharmacodynamics and kinetics, immunology, neuropsychology, biostatistics, life history and computer science. Two endocrine faults--the reduced TSH response to TRH and the failure to suppress cortisol after dexamethasone--provide foci for the organization of several proposed clinical studies. Other conceptual themes are: neuroleptic metabolism in schizophrenic patients; responses of depressed and manic patients to drugs that alter cholinergic function; serotonin function in affective disorders. Two studies explore totally new ground: is hypoglycemia necessary to the behavioral effects of insulin; given a tantalizing biochemical relationship, how do chlordiazepoxide and TRH interact on behavior and endocrine function? A study, epidemiologic in design and scheduled to precede others in performance, assesses the incidence and significance of marginal hypothyroidism in psychiatric inpatients. The effects of psychostimulants on patients with late consequences of closed head injury will also be studied. The Center's four basic science sections (one is new) are tied in various ways to each other and to the five clinical sections (two are new). Several studies focus on the HPT axis: with importance for peptide physiology generally, how is TRH synthesized; how do TRH and cholinergic systems interact in a model of depression (Porsolt test); does even slight hypothyroidism increase memory loss in rats after ECT? Some animal studies explore the utility of peptides as markers of adrenergic or cholinergic activity and the effects early separation on later HPT and HPA function. Other studies resonate with our developing interest in schizophrenia: changes in DA metabolism during the reproductive cycle; the effects of gonadal steroids on DAergic activity; the effects of diabetes on DA receptor functions. Six core groups (three are new) support the clinical and basic science sections and enhance each other's work. Teaching and training activities of the Center have increased in parallel with the depth and span of research activities.