MHCRC-PHYCHOENDOCRINOLOGY: CHILDREN AND ADULTS

该中心的总体目标是建立一个 成人主要精神障碍的神经精神内分泌学研究， 儿童心理健康问题的核心。 在成年人中， 包括抑郁症、躁狂症、酗酒、精神分裂症和精神综合症 与肾透析相关;在儿童中，运动过度，自闭症和精神 迟钝 这些研究的理论基础包括以下原则 神经内分泌学和神经递质生理学原理。 已确定垂体反应故障（TSH对TRH的反应减弱） 在某些抑郁症患者中，在某些情况下，故障与 疾病的状态或处于这些疾病的高风险的特征。 平行垂体反应测试，与TRH，是进行精神病和 多动儿童 相关的神经内分泌研究涉及到 肾透析患者表现出特征性的精神综合征。 成人 精神分裂症有这些轴之间的分离; TSH反应似乎， 与基线皮质醇值呈正相关。 在正常对照和 所有其他诊断组的相关性为负。 改变的 可能是精神分裂症的生化标志。 的 现代遗传学技术被用来探索 情感障碍和酒精中毒以及多动综合征。 亲属 对表现出促甲状腺激素钝化的先证者进行测试，以确定其生理反应是否 在家庭中，过错是疾病的标志。 基础科学的四个学科被用来研究与下列问题有关的问题： 临床目标。 这些是生物化学，动物神经内分泌学， 精神药理学和肽行为药理学。 这些领域的工作 澄清了临床起源的问题;它还提供了表明 临床干预。 相关临床和基础项目的联系为丰富 为几类受训人员提供培训和实践经验。

The overall goal of this Center is to establish an organization for the neuropsychoendocrinological study of the major mental disorders of adults and children which form the hard core of mental health problems. In adults these include depession, mania, alcoholism, schizophrenia and the mental syndromes associated with renal dialysis; in children, hyperkinesis, autism, and mental retardation. The theoretical base for these studies consists of the principles of neuroendocrinology and the principles of neurotransmitter physiology. A pituitary response fault (diminished TSH response to TRH) has been identified in some depressed patients and in some conditions the fault is related to the state of illness or to the trait of being at high risk for these illnesses. Parallel pituitary response testing, with TRH, is carried out in psychotic and hyperkinetic children. Related neuroendocrine investigations are addressed to renal dialysis patients who show characteristic mental syndromes. In adult schizophrenia there is dissociation between these axes; TSH response appears to be positively related to baseline cortisol values. In normal controls and in all other diagnostic groups the relationship is negative. The altered relationships may provide a biochemical marker for schizophrenia. The techniques of modern genetics are used to explore relationships between affective disorders and alcoholism and hyperkinetic syndrome. Relatives of probands who show TSH blunting are tested to establish whether the physiological fault is a marker in families for the demonstration of illness. Four disciplines of basic science are brought to bear on problems relevant to clinical goals. These are biochemistry, animal neuroendocrinology, animal psychopharmacology, and peptide behavioral pharmacology. Work in these areas clarifies problems of clinical origin; it also provides findings that suggest clinical intervention. The nexus of related clinical and basic projects provide a basis for rich training and practical experiences for several categories of trainees.